Coatings
·
2025
·Vol. 15
·期 8
·948
·
IF 2.8
Liting Mu,Yiqi Lian,Shiyu Zheng,Shuo Chang,Ximeng Li,Changhai Sun,Hongbin Qiu
Titanium and its alloys are widely used in orthopedics because of their excellent mechanical properties and biocompatibility; however, their bioinert surface results in sluggish osseointegration and renders implants susceptible to bacterial infection. This study innovatively constructed a “CHP-Ti-MAO” composite coating, which aims to simultaneously improve early osseointegration and antibacterial performance. CHP micron coatings coated with hydroxyapatite (HA) and curcumin (Cur) at different PLGA concentrations (50%, 100%, and 150%) were deposited on the basis of calcium–phosphorus ceramic coatings prepared by micro-arc oxidation (MAO) following the emulsification-solvent volatilization method. It was found that increasing the concentration of PLGA can increase the particle size of the coating, enhance the hydrophilicity, and significantly improve the sustained release performance of the drug. Among them, the 100% PLGA concentration group performed the best: the drug-release half-life reached 75 h, and the corrosion current density was the lowest (9.5 × 10−9A/cm2), showing the best corrosion resistance. This group of coatings has a strong and long-term antibacterial effect on Escherichia coli, with an antibacterial rate of more than 95% at 24 h and more than 99% by day 17. The hemolysis rate of all coatings was lower than 5%, indicating good biocompatibility. This study confirmed that 100% CHP-Ti-MAO composite coating successfully solved the limitations of excessive pore size and insufficient antibacterial persistence of an MAO layer and also had excellent slow-release, corrosion resistance, and high-efficiency antibacterial capabilities, which provided an important basis for the development of a new generation of multifunctional titanium-based implants.
研究领域:
生物材料
·
表面工程
·
生物医学工程
·
纳米技术
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2023
·
IF 6.2
Qi Zhang,Xiaojing Li,Kui Huang,Yongjie Huang,Suwen Zhao,Shanshan Liu,Yang Li
Collagen hybridizing peptides (CHPs) are a powerful tool for targeting collagen damage in pathological tissues due to their ability to specifically form a hybrid collagen triple-helix with the denatured collagen chains. However, CHPs have a strong tendency to self-trimerize, requiring preheating or complicated chemical modifications to dissociate their homotrimers into monomers, which hinders their applications. To control the self-assembly of CHP monomers, we evaluated the effects of 22 cosolvents on the triple-helix structure: unlike typical globular proteins, the CHP homotrimers (as well as the hybrid CHP–collagen triple helix) cannot be destabilized by the hydrophobic alcohols and detergents (e.g., SDS) but can be effectively dissociated by the cosolvents that dominate hydrogen bonds (e.g., urea, guanidinium salts, and hexafluoroisopropanol). Our study provided a reference for the solvent effects on natural collagen and a simple effective solvent-switch method, enabling CHP utilization in automated histopathology staining and in vivo imaging and targeting of collagen damage.
研究领域:
生物化学
·
分子生物学
·
医学材料学
✓ 已验证
DOI
PubMed
高影响因子
POLYMER
·
2025
·
IF 4.5
Peng He,Guanghui Gu,Youyin Xu,Gang Wei,Mingjin Xu
Skin wound healing faces challenges of bacterial infection and environmental stimulation, and hence the design of biocompatible wound dressings with antibacterial and self-healing abilities is promising. Herein, we report the design and synthesis of bioactive composite hydrogels (CHP) with chitosan (CS), hyaluronic acid (HA), and polypeptide (PP). Ascribing to dynamic molecular cross-linking, the fabricated CHP hydrogels exhibit good stability, excellent biocompatibility, injectability, self-healing ability, and antimicrobial activity. Microscopic analysis indicates that the CHP hydrogels maintain a 3D porous dual-network structure, and the porosity of hydrogels is related to the content of PP as the reinforcement. Antimicrobial evaluation of the CHP hydrogels demonstrates significant efficacy against E. coli and S. aureus , with improved performance at higher PP concentration. Furthermore, the hydrogels show enhanced cytocompatibility, minimal hemolysis, and improved in vitro cell proliferation. The tests with wound mouse models indicate that the CHP hydrogels can accelerate wound healing effectively, enhance angiogenesis, and promote tissue regeneration. Histological evaluation confirms complete epidermal regeneration, improved collagen deposition, and increased protein expression. The designed CHP hydrogels present potential clinical applications as a wound dressing material to meet the needs of rapid and effective wound healing.
研究领域:
生物材料学
·
医学工程
·
再生医学
✓ 已验证
产品关联
DOI
高影响因子
STARCH-STARKE
·
2021
·
IF 2.741
Meidong Li,Xiufang Huang,Qin Zhang,Yifeng Zhou,Kai Luo
Four new types of water-soluble polysaccharides are isolated from Cardamine hupingshanensis . Herein, this study examines C. hupingshanensis polysaccharide no. 2 (CHP-2) with a molecular weight of 21.75 kDa. Analysis revealed that CHP-2 is composed of d -glucuronic acid, d -galacturonic acid, glucose, galactose, and L-arabinose. It is speculated that the main connecting bond is →4)-α-D-Glc(p)-(1→), →t)-α-D-Glcp-(1→). Through perfusion experiments using streptozotocin-induced diabetic rats, oral CHP-2 solution is found to significantly reduce food intake, water intake, and fasting blood glucose levels, while increasing the weights of rats. In addition, CHP-2 significantly reduces the serum and liver malondialdehyde contents and increases the activity of the corresponding antioxidant enzymes. Moreover, the effect elicited by the CHP-2 solution is similar to that of phenformin hydrochloride solution. Hence, the results of this study suggest that CHP-2 exhibits blood sugar-lowering and anti-oxidation effects.
研究领域:
药理学
·
生物化学
·
糖尿病研究
✓ 已验证
DOI
高影响因子
STARCH-STARKE
·
2021
·
IF 2.741
Meidong Li,ZiMu Zhang,Ying Luo,Xiufang Huang,Kai Luo
Four new water-soluble polysaccharides has previously been isolated from Cardamine hupingshanensis . In this experiment, the structure of C. hupingshanensis polysaccharide NO. 3 (CHP-3) is analyzed and its in vitro anti-tumor activity is assessed. Through structural analysis, CHP-3 is found to have a molecular weight of 80.64 kDa, and be mainly composed of glucose, galactose, and L -arabinose; The backbone of CHP-3 is mainly composed of →5)-α-L-Araf-(1→ and →4)-α-D-Glc(p)-(1→), respectively. By studying its anti-tumor activity in vitro, it can be concluded that treatment with different concentrations of CHP-3 exerted diverse effects on A549 cells, with an obvious dose-dependent relationship. Moreover, after treatment with 12.8 mg mL −1 CHP-3, significant inhibitory effects are observed on the proliferation, migration, and invasion of A549 cells, indicating that it can be used as an anti-tumor agent for continued in-depth research.
研究领域:
药理学
·
肿瘤学
·
分子生物学
·
化学
✓ 已验证
DOI
高影响因子
THERMOCHIMICA ACTA
·
2019
·
IF 2.251
Hao Wang,Zichao Guo,Wanghua Chen
Optimization of the kinetic parameters with thermal analysis data is an essential issue. In this work, the conjugate direction particle swarm optimization (CDPSO) approach, as a global stochastic optimization algorithm that is suitable to high-dimension optimization problem, is first employed to estimate the kinetic parameters with DSC data. This algorithm combines the global optimization ability of the particle swarm optimization (PSO) and the ability to escape from the local extremum by the conjugate direction algorithm (CD) to find the globally optimal solutions. This algorithm does not require estimation of the initial values of the kinetic parameters. The validation of this method is verified by two cases: DCPO decomposition and CHP decomposition. By comparing the experimental and calculated heat flow results, the accuracy of the fitted kinetic parameters is verified. These two cases prove the effectiveness of CDPSO algorithm in the estimation of high-dimension kinetic parameters using DSC data.
研究领域:
热分析
·
优化算法
·
材料科学
✓ 已验证
DOI
高影响因子
MACROMOLECULES
·
2023
·
IF 5.5
Chongwen Yu,Tianhao Li,Xiao Hu,Ming Liu,Qing Huang,Liu He,Yujie Song
High-performance polymers (HPPs) have good thermal and mechanical properties even under harsh environments and are widely used in aerospace, microelectronics, automobile, and other fields. Traditional employed highly cross-linked HPPs tend to fail in their performance at high temperatures due to the structural defects, which remains a challenge in both scientific investigation and engineering applications for decades. Herein, we employed a cyclosiloxane hybrid polymer (CHP) to investigate a new design strategy to compensate for the structural defects in the highly cross-linked network, which avoids catastrophic failure at high temperatures. Hyperbranched o-carborane was synthesized and used to compensate for structural defects of CHP. The antioxidant ability and toughness of CHP were improved, and it had better mechanical properties over a wide temperature range. Moreover, the anchoring effect of hyperbranched o-carborane in the cyclosiloxane network was systematically investigated. The hyperbranched o-carborane cage could stabilize the CHP network under dynamic thermal stress through anchoring the dangling bonds, and the highly cross-linked network suppressed the disintegration of the o-carborane cage by anchoring boron atoms of the o-carborane cage. Furthermore, the structural evolution mechanism of the o-carborane cage with increasing temperature was proposed. This fundamental research provided new insights into the design of HPPs for harsh environments.
研究领域:
材料科学
·
聚合物化学
·
工程材料
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 14
·3979-3993
·
IF 6.183
Yu Ding,Qiaochu Wang,Guangqu Liu,Yaqian Feng,Wei Zhou
Although nanoparticles (NPs) have emerged as a promising strategy to improve oral absorption of insulin, most of them still have minimal oral bioavailability due to the harsh gastrointestinal (GI) environment and epithelial barriers. A novel platform of oral insulin delivery is herein proposed based on amphiphilic cholesterol-phosphate conjugate (CHP). The CHP was synthesized with a cholesterol moiety as a hydrophobic block and a phosphate group as a hydrophilic block. The structural characteristics of CHP made cholesteryl moieties to point outward to form a shell coated on the surface of NPs, and phosphate groups toward inside as the core via the water-in-oil (W/O) emulsion method. The additional Ca2+ could chelate to phosphate groups in the core to bind adjacent phosphate groups and further increased the stability of NPs (CP-Ca NPs). Phospholipid and glycocholate were modified on the surface of CP-Ca NPs to form hydrophilic corona coated CP-Ca NPs (Hc@CP-Ca NPs) and didn't change the structure of CP-Ca NPs. The NPs exhibited high encapsulation efficiency (>95%) and had high stability in the GI tract by reducing insulin release and protecting insulin from enzymatic degradation. Compared to free insulin, Hc@CP-Ca NPs demonstrated 31-fold higher cellular uptake in Caco-2 cells for 1 h incubation. Furthermore, the transepithelial transport efficiency of Hc@CP-Ca NPs was 12-fold higher than that of free insulin. Moreover, CP-Ca NPs and Hc@CP-Ca NPs generated a rapid-onset and long-lasting hypoglycemic effect following gavage in type 1 diabetic mellitus (T1DM) rats. The pharmacological activity and the relative bioavailability were increased to 13.5% and 12.2%, respectively. Thus, these results indicated that CHP assembled NPs may provide a promising potential for oral insulin delivery by protection and absorption promotion.
研究领域:
药学
·
纳米技术
·
药物递送系统
·
糖尿病研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Arabian Journal of Chemistry
·
2022
·
IF 6.212
Min Liang,Huixia Zhao,Suyi Dai,Chang Yu,Haijun Cheng,Weiguang Li,Fang Lai,Li Ma,Xiongmin Liu
1,3-Butadiene is the simplest conjugated diene, which is widely used in polymer materials, organic synthesis, and other fields. The investigation of its thermal stability and oxidation characteristics is necessary for production, transportation, and use safety. The pressure and temperature behavior of the autoxidation reaction of 1,3-butadiene with oxygen were determined using a custom-designed mini closed pressure vessel test (MCPVT). The effects of free radical initiators CHP and AIBN on the oxidation reaction were investigated. The thermal decomposition characteristics of oxidation products were measured by differential scanning calorimetry (DSC), and its hazards were discussed. The results showed that the oxidation reaction of 1,3-butadiene was easy to occur. Moreover, the activation energies of autoxidation, CHP-initiated oxidation, and AIBN-initiated oxidation reaction were 20.85 kJ·mol −1 , 33.30 kJ·mol −1 , and 56.27 kJ·mol −1 , respectively. In addition, the oxidation products were analyzed by headspace sampler-gas chromatography-mass spectrometry (HS-GC–MS), GC–MS, and iodometry. Some of 1,3-butadiene oxidation products under three conditions are the same, for example, 3-butene-1,2-diol, 4-vinylcyclohexene, 2(5H)-furanone, 2-propen-1-ol, and 2,6-cyclooctadien-1-ol. According to the reaction products, the oxidation reaction pathway of 1,3-butadiene was described. The research results are significant for avoiding fire and explosion accidents in the production, transportation, and application of 1,3-butadiene.
研究领域:
化学工程
·
有机化学
·
热分析
·
安全科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）