E-POLYMERS
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2021
·Vol. 21
·期 1
·072-081
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IF 2.025
Yujuan Qiu,Jirui Fu,Binqing Sun,Xiaojun Ma
Sustainable nanocomposites with transparent, biodegradable, and enhanced mechanical and barrier properties were prepared by the incorporation of SiO 2 into poly(3-hydroxybutyrate- co -3-hydroxyhexanoate) (PHBH) films and subsequent solvent casting. The crystallinity of composites could be increased by 67% with appropriate contents of SiO 2 , which proved that SiO 2 were effective nucleating agents for PHBH. And it was worth mentioning that the contributions of SiO 2 to the crystallization and thermal stability of composites are proved effectively by Avrami relationship and Horowitz and Metzger method. More importantly, compared with PHBH, it had not only an enhancement about 40% and 60% on the tensile strength and elastic modulus, respectively, but also half the reduction of the moisture and oxygen permeability which were much higher than the values of conventional plastics. The above, in conjunction with the low migration rate measured in food substitutes, illustrated unambiguously that the nanocomposites might be suitable for potential application in food packaging.
Graphical abstract
SiO 2 /PHBH nanocomposites with fine crystallization and improved mechanical and barrier properties.
研究领域:
材料科学
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食品科学
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聚合物工程
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DOI
高影响因子
Polymer Chemistry
·
2016
·Vol. 7
·期 39
·6120-6132
·
IF 5.687
Cai Wang,Yudong Zheng,Yi Sun,Jinsheng Fan,Qiujing Qin,Zhenjiang Zhao
A novel block polyurethane was designed and synthesized based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), 4,4′-diphenylmethanediisocyanate (MDI) and poly(ethylene glycol) (PEG). The obtained polyurethanes were characterized by proton nuclear magnetic resonance (1H NMR), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXD). Furthermore, the biodegradability of the synthesized polyurethanes was evaluated at 37 °C in phosphate buffer solution (PBS) at pH 7.4. The results showed that these PHBV-based polyurethanes were degradable in PBS, as indicated by weight loss measurements, scanning electron microscopy (SEM) and FTIR. The cytotoxicity of the novel polyurethane was evaluated using the cell counting kit-8 (CCK8) assay in vitro. Preliminary evaluation of hemocompatibility was carried out via the hemolysis test, dynamic blood coagulation time and platelet adhesion. The current work provides a promising approach to prepare nontoxic and biodegradable polyurethanes with excellent mechanical properties and good hemocompatibility. This new material may find potential application in blood vessel tissue engineering.
研究领域:
生物材料学
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组织工程学
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DOI
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2022
·Vol. 30
·期 8
·3209-3217
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IF 4.705
Han Xiaolong,Jin Yujuan,Huang Jian,Tian Huafeng,Guo Maolin
Hyperbranched polymer with flexible long chains (Ɛ-CL) were synthesized based on hydroxyl terminated hyperbranched polyesters (HBPEs). The prepared HBP-CLs were used to toughen poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) by melt-blending. Comparing with pure PHBV, the crystallinity (X c ) of the PHBV/3.0phr HBP-CLs blends decreased by 10.2% (from 67.8 to 60.9%), the impact strength increased by 533.3% (from 5.1 kJ·m − 2 to 32.3 kJ·m − 2 ), and the elongation at break increased by 160.5% (from 1.62 to 4.22%). With the increase of HBP-CLs, the fracture surface of the PHBV/HBP-CLs blends became rough and a significant decrease in crystallization area can be seen from POM images. Even filamentous structures and tiny holes was formed, which further demonstrated that HBP-CLs acted as an excellent toughening effect on PHBV.
研究领域:
材料科学
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高分子科学
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环境科学
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 139
·期 4
·51551
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IF 3.125
You Wu,Yujuan Jin,Jian Huang,Huafeng Tian,Yunxuan Weng
Phenyl terminated hyperbranched polyesters (HBP-Bs) were synthesized based on Boltorn-type hydroxyl terminated HBPEs and characterized by Fourier transform infrared spectroscopy, nuclear magnetic resonance, gel permeation chromatography, and so forth. The prepared HBP-Bs were used to toughen poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) directly by melt blending. The thermal properties, rheological properties, mechanical properties, and microstructure of the PHBV/HBP-Bs blends were studied in detail. Comparing with pure PHBV, the crystallinity of the PHBV/0.5 phr HBP-Bs blends decreased by 14.10% (from 64.39% to 55.04%), the impact strength increased by 158.30% (from 7.41 kJ·m −2 to 19.14 kJ·m −2 ), and the elongation at break increased by 400.00% (from 0.91% to 4.55%). It can be seen from the scanning electron microscope that the fracture surface of the PHBV/HBP-Bs blends became rough with the increase of HBP-Bs, even with large filamentous structures and tiny holes, which further demonstrated that HBP-Bs acted as an excellent toughening effect on PHBV.
研究领域:
材料科学
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高分子科学
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化学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Dai-Xu Wei,Duanfang Cai,Youguo Tan,Kezhi Liu,Jin-Wei Dao,Xiang Li,Aikeremujiang Muheremu
Huperzine A (HupA) is used in Alzheimer's disease (AD) therapy for its effective inhibition of acetylcholinesterase (AChE) and enhancement of cholinergic neuronal function. However, direct oral administration and injection of HupA cause side effects like nausea, anorexia, and rapid metabolism. Using a tripolymer, poly(3-hydroxybutyrate- co -3-hydroxyvalerate-co-3-hydroxyhexanoate (PBVHx), from the polyhydroxyalkanoate (PHA) family synthesized via synthetic biology, we present a novel AD therapy strategy with peritoneally administered PBVHx microspheres loaded with HupA (HupA-PBVHxMs). This approach extends HupA's metabolic duration in the blood and brain, enhancing AChE inhibition efficacy. Uniformly sized HupA-PBVHxMs, created using microfluidics and rotary evaporation, show up to 70.4 % drug encapsulation efficiency, sustained HupA release for 40 days, reduced neurotoxicity from Aβ25–35, and maintained in vivo HupA supply and AChE inhibition for over 20 days. In cognitive tests, HupA-PBVHxMs improved function in AD mice. Thus, PBVHx microspheres with slower HupA release and lower biotoxicity offer a superior platform for sustained AChE inhibitor release, outperforming commercial PLGA microspheres.
研究领域:
药学
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神经科学
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生物技术
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材料科学
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DOI
PubMed
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2017
·Vol. 32
·期 4
·772-776
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IF 0.447
Xiang Tao,Wang Qingxiu,Duan Lijie,Liu Fude
A conjugated polymer of poly(4,4'-bis(thien-2-yl)azobenzene-co-3-hexylthiophene) (PTAB-H), bearing azo group in main chain and soluble in THF, chloroform, was synthesized through FeCl3 oxidation copolymerization with 3-hexylthiophene, and the monomer of 4,4'-bis(thien-2-yl)azobenzene was synthesized by Sandmeyer reaction and Suzuki reaction. The UV-Vis spectra of PTAB-H reveal that azo group in the main chain can extend the absorption and lower the band gap. The fluorescent spectra, photoluminescence (PL) spectra, cyclic voltammetry (CV) of PTAB-H were recorded.The gel permeation chromatography (GPC), thermogravimetry analysis (TGA), and differential scanning calorimetry (DSC) measurements indicated that the molecular weight Mn, Mw and polydispersity indices (PDI) of the polymer are 10 876 g/mol, 22 338 g/mol and 2.05 respectively and the temperature of 5% weight-loss is 224.6 °C. No glass transition and crystallization melting peak was observed in the temperature range from 30 °C to 400 °C.
研究领域:
材料科学
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有机化学
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DOI
高影响因子
CHINESE CHEMICAL LETTERS
·
2014
·
IF 1.178
Hu-Yan Li,He Li,Bing-Jie Wang,Qun Gu,Zhi-Qiang Jiang,Xue-Dong Wu
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/chitin nanocrystals (CNC) composite scaffolds were synthesized by the salt leaching and thermally induced phase separation (TIPS) technique. The scaffolds have porous structures with macro-pores (100–300 μm in diameters) and micro-pores (10 μm). The surface characteristics of the scaffolds were characterized by X-ray photoelectron spectroscopy (XPS) and static water contact angle measurement, and the mechanical properties were investigated by a compression test. Human adipose-derived stem cells (hADSCs) were seeded onto the PHBV/CNC scaffolds and in vitro cell culture results showed that the composite scaffolds enhanced the hADSCs adhesion, which implies that the material may have potential application in tissue engineering.
研究领域:
生物材料学
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组织工程学
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细胞生物学
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2013
·
IF 3.479
Bingjie Wang,Jun Li,Jianqiang Zhang,Huyan Li,Peng Chen,Qun Gu,Zongbao Wang
Acetylated chitin nanocrystals were prepared through surface modification, and biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/chitin nanocrystals films were produced via solution-casting method. Transmission electron microscopy observations and X-ray diffraction profiles revealed that the rod-like morphology and crystal structure of chitin nanocrystals were maintained. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy results showed that the hydroxyl groups were partly replaced by the acetyl groups on the surface of chitin nanocrystals. The hydrophobic performance of the acetylated chitin nanocrystals was significantly increased according to the contact angle measurements. Differential scanning calorimeter results indicated that the influence of chitin nanocrystals on the crystallization behaviors of PHBV matrix was changed from suppression to assistance after the surface modification. Tensile test showed that the tensile strength and Young's modulus of PHBV/acetylated chitin nanocrystals composites were improved by 44% and 67%, comparing to the improvement of 24% and 43% for PHBV/chitin nanocrystals composites with the addition of 5.0 wt.% nanocrystals into PHBV.
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2011
·
IF 3.463
Jing Wang,Zongbao Wang,Jun Li,Bingjie Wang,Ji Liu,Peng Chen,Menghe Miao,Qun Gu
Chemically modified chitin nanocrystals were synthesized by grafting poly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) onto chitin backbone via chlorination. Acetyl amino group was maintained in the reaction. The chemical structure and morphology of PHBV grafted chitin nanocrystals were characterized by Fourier transform infrared, Transmission electron microscopy and X-ray photoelectron spectroscopy. Contact angle measurement showed that the lipophilicity of chitin was improved by the surface modification. The effects of original chitin and PHBV-graft-chitin nanocrystals on the crystallizing and melting behavior of PHBV were studied by differential scanning calorimeter (DSC). The results indicated that both unmodified and modified chitin nanocrystals suppressed crystallization of PHBV. The melt point of PHBV was increased after being mixed with nanofillers.
研究领域:
材料科学
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生物化学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Zhuo Shi,Hongyuan Guo,Xiaoyang Fu,Xiayu Song,Xiu Zhao,Suozhu Wu
Poly(ANI-APBA) composite was prepared by one-step electrochemical deposition. • DA was detected via boronic acid-diol recognition. • An ultra-wide response range (1.00 × 10 −11 M to 1.00 × 10 −4 M) was obtained. • An ultra-low detection limit (2.41 × 10 −12 M) was obtained. • This sensor was simple, stable, accurate, and highly selective. Dopamine is a crucial neurotransmitter, and the misuse of exogenous dopamine may lead to its residues in animal-derived food products, thereby posing potential risks to human health. In this work, an electrochemical sensor was developed for dopamine detection by integrating the highly conductive framework of polyaniline with poly(3-aminophenylboronic acid) having ortho-diol recognition capability. Initially, a poly(aniline- co -3-aminophenylboronic acid) modified electrode was fabricated through the copolymerization of aniline and 3-aminophenylboronic acid. Subsequently, sensitive detection of dopamine was achieved by monitoring the signal of the potassium ferricyanide probe. The results demonstrated that this electrochemical sensor had a wide linear response range (1.00 × 10 −11 M to 1.00 × 10 −4 M) toward dopamine with a detection limit as low as 2.41 × 10 −12 M. The proposed sensor exhibited superb reproducibility, excellent stability, and high selectivity. This study provided a more efficient analytical approach for sensitive determination of dopamine content in pork products. Download: Download high-res image (213KB) Download: Download full-size image
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高影响因子
POLYMER COMPOSITES
·
2019
·Vol. 41
·期 1
·381-390
·
IF 2.268
Dongna Li,Jirui Fu,Xiaojun Ma
A biocomposite of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH)/nano-SiO 2 modified with silane coupling agent KH570 (KH570-SiO 2 /PHBH) were prepared by solution-casting method. SiO 2 modified with KH570 exhibited improved uniform dispersion than that of pure nano-SiO 2 , and maximum thermal decomposition temperature range and crystallinity ( X c ) of KH570-SiO 2 /PHBH are 8.6°C and 119.7% higher than that of neat PHBH. Compared to the neat PHBH, a 75.4% and 70.8% improvement in Young's modulus and tensile strength were obtained. The water-vapor transmission and oxygen permeance of KH570-SiO 2 /PHBH decreased by 46.2% and 618.6%, respectively. The oxygen barrier property is equivalent to that of polyvinylidene chloride. Simultaneous enhancements on the thermal stability, mechanical, crystallizing, and barrier properties were mainly caused by uniform dispersion of modified nano-SiO 2 and solid interfacial bonding between filler and matrix.
研究领域:
材料科学
·
生物工程
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产品关联
DOI
高影响因子
Nature Communications
·
2020
·Vol. 11
·期 1
·1-10
·
IF 12.121
Zhou Jing,Zhang Linjuan,Huang Yu-Cheng,Dong Chung-Li,Lin Hong-Ji,Chen Chien-Te,Tjeng L. H.,Hu Zhiwei
The ability to determine the electronic structure of catalysts during electrochemical reactions is highly important for identification of the active sites and the reaction mechanism. Here we successfully applied soft X-ray spectroscopy to follow in operando the valence and spin state of the Co ions in Li 2 Co 2 O 4 under oxygen evolution reaction (OER) conditions. We have observed that a substantial fraction of the Co ions undergo a voltage-dependent and time-dependent valence state transition from Co 3+ to Co 4+ accompanied by spontaneous delithiation, whereas the edge-shared Co–O network and spin state of the Co ions remain unchanged. Density functional theory calculations indicate that the highly oxidized Co 4+ site, rather than the Co 3+ site or the oxygen vacancy site, is mainly responsible for the high OER activity.
研究领域:
电化学
·
催化
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材料科学
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光谱学
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DOI
高影响因子
危险品化学品经营许可证（带存储）