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Two new isoquinoline alkaloids from Cryptocarya wrayi and their biological activities

Yun-Lai Liu,Yong Wang,Xiao-Ru He,Li-She Gan,Fan Xu,Yun-Jing Xu,Xiao-Ning Wang,Tao Shen,Zhi-Wang Zhou

Two new isoquinoline alkaloids , cryptowrayines A ( 1 ) and B ( 2 ), along with one known pavine alkaloid (-)-12-hydroxyeschscholtzidine ( 3 ), were isolated from the twigs of Cryptocarya wrayi . The structures of new compounds were elucidated by extensive spectroscopic data analysis and electronic circular dichroism (ECD) calculations. Both compounds 1 and 2 exhibited moderate quinone reductase inducing activity in Hepa 1c1c7 cells.