MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Na Liu,Renzhe Li,Shijian Xiu,Jingyang Jin,Miao Piao,Yeru Bao,So Hee Kim,Zhengri Yin,Aihua Jin,Bo Quan
Non–enzymatic glucose sensors have gained significant attention as promising alternatives to address the limitations associated with enzyme–based sensors. Numerous non–enzymatic glucose sensors have demonstrated effective, non–invasive blood glucose monitoring through the analysis of human body fluids such as urine, saliva, and sweat. In this study, Cu 2 O/Ag nanowires (NWs) nanocomposites were in situ fabricated as electrode materials for non–enzymatic glucose sensors. To enhance the electrocatalytic performance, Cu 2 O/Ag NWs nanocomposites with a distinctive pepero–shaped morphology were synthesized using varied copper precursor ratios, facilitating a systematic investigation of Cu 2 O content on glucose detection. The results reveal that the CA–2 electrode material exhibits outstanding electrocatalytic performance for glucose detection, with sensitivity ranges of 10–100 nM and 1 μM–1 mM, achieving sensitivities of 22,099 and 1474 μA mM −1 cm −2 , respectively, and a detection limit of 3.29 nM. Additionally, this material has shown high efficiency in detecting glucose in urine, highlighting its excellent detection capabilities.
研究领域:
生物传感技术
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纳米材料
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电化学分析
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产品关联
DOI
高影响因子
FOOD CONTROL
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2021
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IF 5.548
Alberta Osei Barimah,Zhiming Guo,Akwasi A. Agyekum,Chuang Guo,Ping Chen,Hesham R. El-Seedi,Xiaobo Zou,Quansheng Chen
Arsenic (As) is one of the toxic, persistent, and lethal heavy metalloids and requires rapid, less costly, and sensitive detection methods. This study proposed a label-free cuprous oxide/silver (Cu 2 O/Ag) surface-enhanced Raman scattering (SERS) nanoprobe to detect total As in tea. Different total As spiked tea concentrations were mixed with the Cu 2 O/Ag SERS nanoprobe for the SERS detection. Quantitative models were established for predicting the total As in tea by comparatively applying chemometric algorithms. Amongst the algorithms, competitive adaptive reweighted sampling partial least squares (CARS-PLS) optimized the most effective spectral variables to predict the total As in tea efficiently. The CARS-PLS gave the highest correlation coefficient value (R p = 0.9935), very low root means square error (RMSEP = 0.0496 μg g −1 ) in the prediction set and recorded the highest RPD value of 8.819. The proposed nanoprobe achieved a lower detection limit (0.00561 μg g −1 ), excellent selectivity, satisfactory reproducibility, and stability. No significant difference was recorded when the performance of the Cu 2 O/Ag total As SERS sensor was compared with the inductively coupled plasma mass spectrometry (ICP-MS) method. Therefore, this developed Cu 2 O/Ag coupled chemometrics SERS sensing method could be used to efficiently determine, quantify, and predict total As in tea to promote monitoring of heavy metal contaminants.
研究领域:
食品科学
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分析化学
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环境科学
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DOI
高影响因子
ChemistrySelect
·
2023
·Vol. 8
·期 34
·e202302723
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IF 2.1
Jingnan Liu,Haoran Jia,Jiawei Guo,Wen Zhang
Graphical Cu 2 O−Ag nanocomposites were prepared and can be used with facile method for the electrochemical quantification of catechol. The rational surface configuration of Cu 2 O−Ag showed synergistic effects that improved the adsorption of catechol, facilitating interfacial electron transfer. Highly sensitive and selective electrochemical sensors are essential for human health, especially for monitoring the state of environmental pollutant content. Here, Cu 2 O nanocubes uniformly decorated with Ag nanoparticles were synthesized by a tractable wet-chemical method. The electrochemical studies confirm that the Cu 2 O-Ag-16 composite shows increased electrochemical activity for catechol determination compared with either the bare Cu 2 O or the other two as-proposed Cu 2 O−Ag catalysts (Cu 2 O−Ag-8, Cu 2 O−Ag-24). More specifically, the Cu 2 O−Ag-16 presents excellent electrochemical responses towards catechol detection over wide linear ranges of 0.05 μM – 1 mM and 1 mM – 5 mM, with high sensitivity and low detection limits (50 nM). Furthermore, the as-proposed sensor also displays good reproducibility, with a relative standard deviation of 2.3 % (n=3). Satisfactory recoveries in the range of 98.3 % to 101.2 % or 98 % to 100.7 % for lake water and/or tap water indicate the reliability of the sensor for catechol detection in practical applications. Constructing such composite structures to manipulate the local charge distribution for outstanding electrochemical sensing properties would provide us with an innovative strategy to explore other highly efficient electrode materials.
研究领域:
分析化学
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环境科学
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材料科学
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产品关联
DOI
高影响因子
Journal of Materials Research and Technology-JMR&T
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2021
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IF 5.039
Chengli Yao,Xinna Gao,Xuan Liu,Yuhua Shen,Anjian Xie
It is a challenging and valuable work to synthesize surface enhanced Raman scattering (SERS) substrate with low cost and high performance by simple methods, and use it to detect pesticide residues in food. Here, Ferrero® chocolate-like Cu 2 O@Ag microspheres (FRC-Cu 2 O@Ag) were fabricated by a facile in-situ redox reaction. Cu 2 O directly acted as templates and reducing agents to induce the nucleation and growth of Ag nanoparticles on the microspheres surfaces. The prepared semiconductor-noble metal hybrids of Cu 2 O@Ag were utilized as SERS substrates to detect 4-mercaptobenzoic acid (4-MBA) and thiram molecules. The distinguished SERS effect was achieved when target molecules absorbed on the FRC-Cu 2 O@Ag composite. The substrate presented excellent sensitivity and reproducibility for the detection of 4-MBA and thiram with the limit of 10 −10 and 10 −9 M, respectively. Due to combining both advantages of electromagnetic enhancement of Ag metals and chemical enhancement of Cu 2 O semiconductors, the obtained FRC-Cu 2 O@Ag microspheres provided a SERS platform to conveniently detect molecules with thiol groups. When it was applied to detect thiram residues on apple peel and the detection limit was 1.2 × 10 −7 M, low than maximal residue limit (MRL) of 7 × 10 −6 M in fruit prescribed by the U.S. Environmental Protection Agency (EPA).
研究领域:
食品科学
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分析化学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry C
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2025
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IF 5.1
Xiangyang Chen,Zhensen Liang,Aodi Hu,Minggang Zhao
L-Cysteine (L-Cys), a sulfur-containing amino acid, plays a crucial role in various biological processes. Rapid and accurate detection of L-Cys in the human body is significant for clinical diagnosis and drug analysis. However, classic electrochemical sensing mechanisms are usually based on redox reactions, and substances with similar redox properties in the serum can easily interfere with the detection process. In this study, we present a novel approach for the detection of L-Cys using Schottky barriers of Ni/Cu2O/Ag nanocubes. The electrode exhibits excellent selectivity towards L-Cys due to the specific interaction between Cu2O and L-Cys through the formation of Cu–S bonds. The Schottky barrier at the Cu2O/Ag interface, formed due to the difference in work functions, impedes electron transfer and can be modulated by the adsorption of charged L-Cys molecules. The introduction of light irradiation enhances the barrier modulation capability, resulting in improved sensitivity. Experimental results demonstrate that the Ni/Cu2O/Ag electrode exhibits a linear response to L-Cys concentration within 0–2400 nM at pH 3.0 and pH 7.0, with a low detection limit of 11.86 nM. The electrode shows excellent performance in real sample analysis, exhibiting high recovery rates and low relative standard deviations. The light-assisted barrier enhancement mechanism provides a new avenue for the development of highly selective and sensitive electrochemical sensors.
研究领域:
电化学传感
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纳米材料
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生物传感器
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分析化学
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表面科学
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
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2019
·Vol. 187
·期 1
·1-10
·
IF 5.479
Li Yue,Wang Yan,Wang Mingchao,Zhang Jinyue,Wang Qingwei,Li Hongji
In a new method for the determination of trace levels of chlorophenols in river waters, detection via surface-enhanced Raman scattering (SERS) is combined with recognition by a molecularly imprinted polymer (MIP). Nanoparticles of type Cu 2 O@Ag were synthesized by attaching silver particles to the surface of Cu 2 O nanoparticles. The Cu 2 O@Ag were then coated with a layer of a MIP that was obtained by atom transfer radical polymerization using from methacrylic acid as monomers and 2,6-dichlorophenol as the template. The morphology of Cu 2 O is found to be flower-like. The Cu 2 O@Ag-MIPs displays a strong SERS effect. Following removal of the template by rinsing with the mixture solution of methanol/acetic acid (9/1, v /v), the material was used to selectively bind 2,6-dichlorophenol, 2,4-dichlorophenol and 2,4-dichlorophenol. The SERS peak intensity at 1580 cm −1 increases linearly with the concentration of the various chlorophenols in the range from 10 nM to 1 mM, and the detection limit is 5.8 nM. The imprinting factor is 4.62. The method was applied to the analysis of (spiked) river water, with recoveries ranging from 91.8 to 115.4% and relative standard deviations of <4.5%.
Graphical abstract
研究领域:
环境科学
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分析化学
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纳米技术
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材料科学
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产品关联
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
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2024
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IF 6
Yujiao Xie,Xue Li,Lei Xu,Chenguang Zhang,Yong Ren,Xiaofeng Shi,Liyun Fu,Jing Wang,Xiawei Xu,Yue Liu,Yue Hu,Zhouxu Zhang,Jiahao Zhang,Ting Yao,Wenzhi Ren,Tianxiang Chen,Xiaoyu Qian,Xiaotian Wang,Jie Lin,Aiguo Wu
Early diagnosis and treatment of liver fibrosis can effectively prevent chronic liver disease from developing into hepatocellular carcinoma (HCC). Conventional techniques to detect liver fibrosis are complex and expensive. The development of non-invasive and sensitive surface-enhanced Raman scattering (SERS) can significantly reduce the time and cost, which is important for improving the efficiency of diagnosis and detection of liver disease. In this study, we developed a cubic core–shell Cu2O@Ag SERS bioprobe for label-free identification of HCC and hepatic fibrosis. The constructed composite substrate has shown impressive SERS sensitivity and good stability. Trace molecules (alizarin red and rhodamine 6G) with concentrations as low as 10−10 mol L−1 could be detected. Cubic Cu2O@Ag also exhibited good SERS stability, since the smallest relative standard deviation (RSD) of Cu2O@Ag-MB (methylene blue) was only 8.80%. Then, the spectral analysis of these three molecules (AR, MB, and R6G) was carried out by applying a machine learning-assisted LDA model, and the classification accuracy reached 100%. Subsequently, four different types of hepatocytes were identified and classified by using the established model and label-free SERS detection with a desirable accuracy of 91.38%. This innovative technology will further facilitate the early diagnosis of HCC and liver disease and assist in the rationalization of clinical treatment.
研究领域:
生物医学工程
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分析化学
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医学诊断
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机器学习
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
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2023
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IF 6.7
Gaojian Lv,Lifang Sun,Hui Gao,Chengcheng Ma,Wen Li,Shougang Chen
The construction of heterojunction has been considered as an effective strategy to achieve charge separation and improve photocatalytic activity. In this work, stable reduced Cu 2 O/Ag/Bi 2 MoO 6 (Cu 2 O/Ag/BMO) nanocomposites with high-efficiency antibacterial activities were synthesized via a simple wet chemical method. After illumination of 30 days, Cu 2 O/Ag/BMO still showed excellent antimicrobial capability against P. aeruginosa and S. aureus . The photoluminescence spectroscopy was used to analyze the electrons and holes recombination efficiency of samples, which suggested Cu 2 O/Ag/BMO could promote electron-hole separation and extend the lifetime of photogenerated carriers. The results of photocurrent responses test suggested that the photocurrent density of Cu 2 O/Ag/BMO was four times stronger than the Cu 2 O, which indicated the higher separation efficiency of electrons and holes pairs for the formed Cu 2 O/Ag/BMO. Besides, density functional theory proved that Ag nanoparticles could promote the electrons transfer from the Bi 2 MoO 6 layer to the Cu 2 O layer which facilitated the separation of photogenerated electron-hole pairs. Therefore, electrons and holes could better participate in the redox reactions and then generate more active substances (•OH and •O 2 – ), improving the antimicrobial ability. Therefore, the prepared Cu 2 O/Ag/BMO composites has a great application prospect in the antifouling field.
研究领域:
材料科学
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光催化
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纳米技术
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环境科学
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微生物学
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产品关联
DOI
高影响因子
Nano Today
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2024
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IF 13.2
Yujiao Xie,Chao Chen,Chenguang Zhang,Lei Xu,Zihou Li,Wenzhi Ren,Xiawei Xu,Yong Ren,Jie Lin,Aiguo Wu
Conventional methodology for accurate identification of breast tumor subtypes is complex and time-consuming. Label-free SERS (surface-enhanced Raman scattering) enables rapid detection of biomolecules and provides intrinsic fingerprint information of analytes. Exploring reliable SERS bioprobes with high sensitivity and repeatability is essential for efficient typing of cancer cells. In this study, a novel core-shell noble metal-semiconductor Cu 2 O@Ag heterostructure with uniform morphology and outstanding SERS activity for label-free detection has been proposed. The Cu 2 O@Ag SERS substrates exhibit exceptional sensitivity to detect 4 nitrophenthiol (4NTP) at extreme low concentration (10 −15 M), and the SERS spectra demonstrate excellent selectivity and repeatability (RSD ≈ 8.84%). The enhancement mechanism is attributed to the synergistic enhancement of photoinduced charge transfer and boosted surface plasmon resonance effect, confirmed by reduced fluorescence lifetime of methylene blue on SERS substrates and enhanced electromagnetic field intensity via finite-difference time-domain computational simulation. The ultrahigh sensitivity and good signal stability endow Cu 2 O@Ag SERS bioprobe potential for accurate detection of four breast cancer cells subtypes. The rich fingerprint information from SERS spectra is processed using linear differentiation analysis, revealing a high accuracy of 93.3% for subtypes classification. These results demonstrate an excellent SERS bioprobe with high sensitivity and repeatability for precision diagnosis has been developed.
研究领域:
材料科学
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生物医学工程
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癌症研究
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分析化学
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产品关联
DOI
高影响因子
Chemistry Africa-A Journal of the Tunisian Chemical Society
·
2020
·Vol. 3
·期 3
·749-758
·
IF 0
Wang Xue,Lu Jiajun,Tang Xiaomin,Qiu Ping
In this paper, we built the Cu 2 O@Ag nanocomposites-catalyzed 3,3′,5,5′-tetramethylbenzidine (TMB)–H 2 O 2 system for sensitive, rapid, and low-cost colorimetric sensing of uric acid (UA). Firstly, Ag nanotriangles were synthesized by dynamic method, and then Cu 2 O was encapsulated on the nanoflakes to synthesize Cu 2 O@Ag nanocomposites. Characterization of the structure and morphology of nanocomposites material were characterized by transmission electron microscopy, X-ray energy-dispersive spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy. Cu 2 O@Ag nanocomposites could catalyze the oxidation of TMB by H 2 O 2 (which is produced by enzymatic oxidation of UA), and the color changes from colorless to blue can be observed directly with the naked eyes or can be detected by UV–Vis spectrophotometer. The colorimetric sensor provided a linear absorbance response in the 0.5–100 μM UA concentration range with a 0.4 μM detection limit (S/N = 3). The recovery of UA in human serum by the proposed sensor is over 95.7%. Thus, these results imply that the UA sensor provides an effective tool in fast clinical analysis of gout without the need for expensive and advanced equipment.
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DOI
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Jiawei Dai,Deyu Zhu,You Xu,Jiannan Zhu,Xiaoling Liu,Guichan Xu,Zhengyun Wang,Rong Chen,Hongfang Liu,Guangfang Li
An efficient electrocatalytic conversion of CO2 into valuable multicarbon (C2+) products requires enhanced C–C coupling of C1 intermediates. Herein, we combine a tandem effect with a confinement strategy to construct a hollow Cu2O@Ag nanoshell electrocatalyst with a well-defined porous structure to improve the *CO intermediate coverage on the catalyst surface. In CO2 electroreduction, in situ Raman spectroscopy shows that the introduction of Ag can not only promote the CO intermediate production but also improve the stability of Cu+ to capture the *CO intermediate due to a CO-tandem effect, and the fine-tuned hollowness degree and pore size of Cu2O@Ag create a spatially confined microenvironment for trapping CO2 as well as the enrichment of CO, which greatly facilitate subsequent C–C coupling for C2+ product. The optimized Cu2O@Ag-45 with a specific nanoconfinement exhibits an enhanced ethylene (C2H4) production under the wide potential range from −0.4 to −1.2 V (vs RHE), and a Faradaic efficiency of 55.4% for C2+ products could be achieved at −1.2 V (vs RHE). This study highlights a promising strategy for the electrochemical reduction of CO2 to C2+ products on efficient C–C coupling catalysts.
研究领域:
化学
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材料科学
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催化科学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 41
·20513-20522
·
IF 9.931
Yunyun Huang,Aoxiang Xiao,Guanhua Hou,Hongtao Li,Tuan Guo,Bai-Ou Guan
An in situ strategy to understand the photocatalytic performance of Cu2O–Ag@rGO nanocomposites through interfacial photocatalysis on an optical microfiber has been proposed and experimentally demonstrated. The photocatalysts were conjugated on the surface of an optical microfiber immersed in an organic solution, forming an interface consisting of photocatalysts and organic molecules between the silica microfiber and the solution, which was within the evanescent field of the optical microfiber. In the photocatalytic process, the decomposition of organics changed the refractive index (RI) of the interface. The interaction between the evanescent wave and the microfiber interface modulated its optical spectrum. Therefore, the optical microfiber monitored the photocatalytic performance of the photocatalysts in real-time and in situ. The results reveal that the photodegradation efficiency of Cu2O–Ag@rGO was almost twice that of Cu2O, while the degradation rate constant was more than five times larger, because the coupling between the silver nanoparticles and reduced graphene oxide (rGO) enhanced the photocatalytic performance of Cu2O. By taking advantage of its miniature size and mechanical flexibility, the microfiber can directly probe a real matrix to study the local photocatalytic performance. This strategy is suitable for the evaluation of most photocatalysts and might provide a new perspective to assess the photocatalytic performance of the catalysts.
研究领域:
材料科学
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光学
·
环境科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）