Biomedical Materials
·
2023
·Vol. 18
·期 6
·065006
·
IF 4
Jing Zhang,Miaomiao Hu,Changchun Wen,Jian Liu,Fang Yu,Juan Long,Xiang-Cheng Lin
Single tumor treatment method usually has some defects, which makes it difficult to achieve good therapeutic effect. The ingenious combination of multiple tumor treatment methods on a single nanoplatform to achieve multifunctional treatment can effectively improve the efficiency of treatment. The targeted modification of nanomaterials can augment the precision of nanotherapeutic drugs in tumor treatment. Herein, a multifunctional nanoplatform (CeO2@CuS@PDA-FA) based on cerium dioxide nanoparticles engineered with copper sulfide (CeO2@CuS) has been constructed for synergistic photothermal therapy (PTT) and chemodynamic therapy (CDT). The CeO2@CuS were coated using polydopamine (PDA), and the modification of PDA surface by folic acid, in order to achieve the targeted effect for tumors. The localized hyperthermia induced by PTT can further improve the CDT efficiency of the nanoplatform, leading to a PTT/CDT synergistic effect. The nanoplatform possessed the capability of cancer cell-targeted and achieved better therapeutic efficacy in vitro. This work provided a new strategy for combined multifunctional theranostic platform and shows strong potential in practical applications.
研究领域:
纳米医学
·
癌症治疗
·
生物材料
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 7
·1396-1404
·
IF 5.344
Shang-Qing Zhang,Xun Liu,Qi-Xuan Sun,Omar Johnson,Ting Yang,Ming-Li Chen,Jian-Hua Wang,Wei Chen
In this study, CuS@PDA nanoparticles were synthesized and used to create a novel tumor-targeting nanocomposite platform composed of copper sulfide@polydopamine–folic acid/doxorubicin (CuS@PDA–FA/DOX) for performing both photothermal and chemotherapeutic cancer treatment. The nanocomposite platform has ultrahigh loading levels (4.2 ± 0.2 mg mg−1) and a greater photothermal conversion efficiency (η = 42.7%) than CuS/PDA alone. The uptake of CuS@PDA–FA/DOX nanocomposites is much higher in MCF-7 cells than in A549 cells because MCF-7 cells have much higher folic acid receptors than A549. Under near infrared (NIR) irradiation, the CuS@PDA–FA/DOX system using a synergistic combination of photothermal therapy and chemotherapy yields a better therapeutic effect than either photothermal therapy or chemotherapy alone. The treatment is very effective with the cell viability is only 5.6 ± 1.4%.
研究领域:
肿瘤学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yujie Duan,Wei Wang,Ji Jia,Xiaohang Tuo,Yumei Gong,Fengyu Quan
A polyelectrolyte system consisting of sodium alginate (SA) and quaternary ammonium chitosan (QAC) blended with polydopamine-coated copper sulfide particles (CuS@PDA) was chosen to investigate the function of CuS@PDA in the uniform binary blending of anionic and cationic polyelectrolytes in detail. A smart composite fiber SA/QAC/CuS@PDA was prepared via a dry-wet spinning technique. With the addition of CuS@PDA (about 4.3 % in fiber), the as-prepared SA/QAC/ [email protected] fibers ( [email protected] SCFs) showed notably enhanced intensity 359.2 MPa, excellent moisture response, and photothermal conversion performance, with the temperature increasing from 25.9 to 80.7 °C as irradiated under a 980 nm infrared lamp at distance 20 cm away for 120 s. The photothermal performance was maintained after 6 lighting on-and-off cycles. The tensile strength decreased ~23.8 % after 4 cycles, then remained fixed. The diameter increases to ~480 % in wet state but decreases to the original size in dry state for 10 cycles. When the fabric with 90 wt% [email protected] SCFs was used as a water evaporator, the water evaporation rate and efficiency were 1.68 kg·m −2 ·h −1 and 102 % under 1 sun irradiation. This work provides a simple and ecofriendly strategy for fabricating photothermal fabrics by designing and preparing composite fibers.
研究领域:
材料科学
·
环境科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Jiayao Wang,Jingguo Li,Shaokui Cao,Yingliang Liu,Jun Shi
In recent years, the remotely multi-responsive chitosan (CS) hydrogel has been garnering extensive attention owing to its remarkable potential in biomedical applications. Meanwhile, it presents a wide range of uses in the realm of controlled drug delivery and photothermal chemical combination therapy. In this paper, the CS/β-glycerophosphate disodium salt (β-GP) physical crosslinked network was employed as the framework to encapsulate near-infrared (NIR) responsive hollow copper sulfide (CuS)/polydopamine (PDA) nanoparticles, and the NIR/pH synergistic responsive CS/CuS/PDA hydrogel was fabricated. The negatively charged β-GP, along with the hollow CuS/PDA nanoparticles, played a key role in promoting the creation of abundant electronegative cavities. As a result, the hybrid hydrogel achieved an impressively high DOX loading rate, reaching up to 95.5%. The CS/CuS/PDA hydrogel exhibits excellent pH responsiveness, which could be attributed to the disintegration of the CS/β-GP network under acidic buffer solution. In addition, hollow CuS/PDA nanoparticles embedded in the hydrogel endow the hydrogel with excellent NIR photothermal responsiveness, which significantly promotes the release of DOX. Consequently, the CS/CuS/PDA hydrogel reveals excellent synergistically enhanced NIR, pH, and thermal triple-responsiveness, indicating its tremendous promise in the field of controlled drug release.
研究领域:
生物医学工程
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材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
RENEWABLE ENERGY
·
2026
·
IF 9.1
Yanbo Liu,Jiajia Zheng,Yanan Liu,Xiaoxiao Wang,Yen Wei,Seeram Ramakrishna,Bo Yang
Solar-driven interfacial evaporators represent a promising approach to alleviate global freshwater scarcity. However, practical applications still face challenges such as low evaporation efficiency, salt scale accumulation, and unstable evaporation. Therefore, we polymerized and deposited polydopamine (PDA) and hydrothermally synthesized CuS nanoparticles onto a polyimide (PI) aerogel to prepare a superhydrophilic porous CuS/PDA@PI nanofibrous aerogel. The aerogel achieved >97% light absorption over 200-2500 nm and a water evaporation rate of 1.963 kg m −2 h −1 under one sun irradiation (1 kW m −2 ). The apparent total evaporation efficiency reached 119.8%, exceeding the theoretical limit due to additional environmental heat harvesting. Even after 1200 min of cycling, the aerogel maintained an apparent total evaporation efficiency of 116.6%. The evaporator maintained an apparent total evaporation efficiency of 88.7% under a salt (20%) environment and exhibited self-cleaning performance. Furthermore, the aerogel exhibited purification performance for dye wastewater, acidic and alkaline solutions, and seawater. This superhydrophilic evaporator provides a viable route for practical seawater desalination.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2025
·
IF 6.7
Zhou Shi,Chenxi He,Hao Huang,Xile Huang,Tong Hu,Yijia He,Dazhi Yang,Simeng Xia,Haojie Zhang,Lin Deng
The frequently detected antibiotics in aquatic environments can induce antibiotic-resistance genes, thereby posing significant risks to both ecosystems and human health. Thus, it is imperative to remove antibiotics from water environments. We constructed a novel polydopamine-loaded copper sulfide (CuS@PDA) through a simple hydrothermal method to activate H 2 O 2 to degrade tetracycline (TC). Compared to CuS/H 2 O 2 , the CuS@PDA/H 2 O 2 system not only achieved efficient TC removal with kinetic rate constant of 0.20 min −1 , but also showed much lower Cu 2+ ions leaching (3.81 mg/L from CuS vs. 0.21 mg/L from CuS@PDA). Besides, CuS@PDA exhibited remarkable recyclability with 93 % removal in the fifth consecutive cycle. Mechanisms analysis revealed that Cu and S contributed to the H 2 O 2 activation and S promoted the conversion of Cu(II) to Cu(I), beneficial for the production of reactive oxygen species. 1 O 2 was found to play the dominant role in the degradation of TC on the basis of quenching tests and electron paramagnetic resonance (EPR) analysis. PDA in CuS@PDA composites facilitated easier complexation with H 2 O 2 and conferred stronger oxidation capability. Lastly, the TC degradation pathway by CuS@PDA/H 2 O 2 was proposed, and the ecotoxicity of its degradation intermediates was estimated. In conclusion, this work demonstrates that the use of PDA can not only improve the catalytic activity and recyclability of CuS towards H 2 O 2 activation for organic pollutants degradation, but also greatly mitigate copper ions leaching.
研究领域:
环境科学
·
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 21
·11465
·
IF 4.9
Zeliang Li,Xiaoxuan Ma
Surgical resection is the primary treatment for melanoma; however, preventing tumor recurrence after resection remains a significant clinical challenge. To address this, we developed a multifunctional nanocomposite hydrogel (H-CPG) composed of glucose oxidase (GOx)-coated CuS@PDA@GOx (CPG) nanoparticles, aminated hyaluronic acid (HA-ADH), and oxidized rhizomatous polysaccharides (OBSP), which are interconnected through hydrogen bonds and dynamic Schiff base linkages. In the acidic tumor micro-environment, the hydrogel releases GOx, catalyzing the production of hydrogen peroxide (H2O2), which enhances chemokinetic activity through a Cu2+-mediated Fenton-like reaction. This process generates hydroxyl radicals that intensify oxidative stress and promote macrophage polarization from the M2 to M1 phenotype. This polarization triggers the release of pro-inflammatory cytokines, thereby inhibiting tumor recurrence. Additionally, the hydrogel induces photothermal effects that help eradicate residual bacteria at the wound site. Overall, the H-CPG hydrogel offers a dual mechanism to prevent melanoma recurrence and reduce resistance to monotherapy, presenting a promising strategy for postoperative tumor management.
研究领域:
肿瘤学
·
纳米技术
·
生物医学工程
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）