ORGANIC ELECTRONICS
·
2022
·
IF 3.868
Hao-Feng Lin,Xiao-Xu Yang,Song Chen,Ya-Ru Kang,Jue Wang,Zhen-Yu Jiang,Woochul Yang,Shulai Huang,Yan Xi,Xue-Dong Wang,Wan-Feng Xie
It has been demonstrated that organic semiconductor micro-/nanocrystals with multicolor emission/waveguide characterizations would be widely utilized as ideal building blocks for the next generation of miniaturized optical, electronic and logic operation devices. However, rational synthesis of one dimensional micro-/nanocrystals with multicolor emission and optical waveguide performances are highly desirable and still remain a challenge. Here, the DCM doped Alq 3 single-crystalline microrods are fabricated via a facile solution-exchange method. It is found that a redshift in light-emission frequency is extremely sensitive to the doping concentration of 4-(dicyano-methylene)-2-methyl-6-(4-dimethylamino-styryl)-4Hpyran (DCM) guest molecule. The green emission at 527 nm of Alq 3 is the main emitting peak when doping concentration of DCM in Alq 3 :DCM is less than 150:1. Then, when the doping concentration of DCM in Alq 3 :DCM is larger than 100:2 such as 100:10, the red emission at 635 nm becomes the dominant emitting peak, the redshift amounts can reach to roughly 108 nm. In addition, the DCM-doped Alq 3 microrods exhibit a lower optical loss of 0.019 dB/μm as a multicolored waveguide material. Therefore, it is demonstrated that the DCM-doped organic micro/nano crystals can be utilized as a promising building block for various optoelectronic components.
研究领域:
材料科学
·
光学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2022
·
IF 4.889
Yaping Zhang,Guobo Li,Peng Wu,Hongqiang Yang,Sheng Wang,Kai Shen,Ling Wang
TiO 2 -Vo support with abundant oxygen vacancy was prepared by hydrothermal method, purchased TiO 2 -P for comparison, and Pd 0.12 V 4 /TiO 2 catalysts with different TiO 2 structures were prepared to investigate catalytic oxidation for dichloromethane (DCM). Pd 0.12 V 4 /TiO 2 -Vo catalyst showed excellent low temperature DCM removal efficiency, T 90 of which reduced to 290 ℃, and Cl resistance was maintained in 40 h. Abundant oxygen vacancy of TiO 2 -Vo was formed in transformation process of part anatase TiO 2 to rutile phase. The obtained Pd 0.12 V 4 /TiO 2 -Vo catalyst possessed rich acid sites, higher adsorbed oxygen (O ads ) ratio and better oxygen mobility, which inhibited loss of active components and improved DCM removal efficiency. DCM removal efficiency of Pd 0.12 V 4 /TiO 2 catalyst was reduced by HCl, while negative effect in the way of weakening competitive adsorption between HCl and DCM, that would be reduced by TiO 2 supports modification. The present work is favorable for further DCM removal catalyst anti-Cl poisoning modification and application in manufacture industry.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Xuehao Ma,Xilang Jin,Haiyan Bai,Liyuan Ma,Xiao Li,Xingliang Fang,Weixing Chen,Mengyao She
Water content was an essential indicator in organic solvents, and it was necessary to develop a facile, cheap and readily available tool for the real-time, specifical and sensitive detection of water content. In this work, two novel D-π-A type near-infrared fluorescence sensors ( DCM-1 and DCM-2 ) were designed and synthesized for the detection of trace water in organic solvents. DCM-1 and DCM-2 with solvent-dependent effects and large Stokes shift (>120 nm) showed good linear “intensity-to-content” relationships in four commonly-used organic solvents, and accomplished the ultra-fast and high-accuracy detection of the trace water in organic solvents. More importantly, a portable, fast, and accurate smartphone-assisted visual assay was designed for visual quantitative detection of the water content in organic solvents with a detection limit as low as 1.028 % v/v (e.g. in ethanol) and a wide detection range (0–60 % v/v). The smartphone-based visual assay was further applied to estimate the water content in disinfection alcohol and commercial liquor, which furnished a new strategy and broad prospects to achieve the accurate onsite detection of water content.
研究领域:
化学传感
·
分析化学
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产品关联
DOI
PubMed
高影响因子
SENSORS
·
2022
·Vol. 22
·期 3
·1075
·
IF 3.847
Xin Wang,Weiguang Shi,Yuda Wang,Dan Cheng,Jiahui Liu,Shihan Xu,Wei Liu,Biao Dong,Jiao Sun
A typical and environment-friendly fluorescent polyamine-amine (PAMAM) features good compatibility and unique surface modification, while it is restricted by a low fluorescence property performance and an unclear fluorescence mechanism. In this work, we prepared blue fluorescent PAMAM polymer dots (PDs) via a simple hydrothermal method based on dichloromethane (DCM) and 2.0G PAMAM. The quantum yield achieved was 32.1%, which was 25 times stronger than that of 2.0G PAMAM due to the lone-pair electron leap of the amine groups, the aggregation of carbonyl groups, as well as the crosslinking induced by DCM inside the PAMAM. In addition, the fluorescent 2.0G PAMAM-DCM PDs show a great Fe3+sensing property with the detection limit of 56.6 nM, which is much lower than the safety limits (5.36 μM) in drinking water, indicating its great potential for Fe3+detection in aqueous media.
研究领域:
材料科学
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分析化学
·
纳米技术
·
环境监测
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DOI
高影响因子
Environmental Technology & Innovation
·
2022
·
IF 7.758
Xijuan Chao,Dezhi Yao,Chuxuan Chen,Chengfei Zhang
Hemin, an iron (III) complex of protoporphyrin IX dissociated from met Hb, exhibits many biological functions. The excess of hemin can be extremely toxic, such as permeabilizing cellular membranes and oxidizing proteins, lipids and nucleic acids. Therefore, it is of great significance to achieve hemin detection. Here, a simple and environmental-friendly fluorescence-based approach for hemin detection is reported by using synthesized dicyanomethylene-4H-pyrans-morpholine ( DCM-ML ) as a fluorescent signal reporter molecule in the presence of human serum albumin (HSA). DCM-ML is non-fluorescent in aqueous solution, but emits 630 nm fluorescence signal with HSA. Upon hemin addition, the specific competitive-binding towards HSA results in the release of DCM-ML reporter, accompanied by a gradual decrease of fluorescence intensity of the DCM-ML /HSA system. Importantly, the fluorescence intensity at 630 nm exhibits a good linear relationship ( R 2 > 0.99) with the added concentration of hemin at the range of 0– 2 . 8 μ m ol/L, giving a quite low detection limit of 9.84 nmol/L in PBS buffer. The DCM-ML /HSA system possesses strong anti-interference capacity against other biomolecules or ions, and fast response time (30 s) for hemin and a wide pH range of 7–10 is generally suitable for the detection system. At last, the applications of DCM-ML /HSA system for hemin detection in environmental and biological systems are successfully demonstrated, indicating its practical application potential in the future.
研究领域:
生物化学
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医学检测
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分析化学
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Xizi Yu,Lie Xiang,Sheng Yang,Shuanglin Qu,Xianqing Zeng,Yibo Zhou,Ronghua Yang
Developing a reliable fluorescence probe is crucial for accurately monitoring sodium dithionite (Na 2 S 2 O 4 , SDT) in biosystems, but the current reported azo-based ones suffers from short excitation/emission wavelengths and relative slow response speed. To address this issue, we herein present a novel near-infrared emissive fluorescence probe for SDT, namely DCM-MQ , consisting of a dicyanomethylene-benzopyran fluorogenic reporter and a 1-methylquinolinium as recognition moiety. On the basis of the specific reduction mechanism, DCM-MQ exhibited a rapid colorimetric and fluorescent recognition for SDT (less than 3 s) with large Stokes shift (112 nm) and high sensitivity (detection limit was 19 nM). The fluorescence imaging results demonstrate that DCM-MQ is competent for monitoring SDT in living systems.
研究领域:
生物化学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE RESEARCH
·
2026
·
IF 2.5
Wang Zhao,Jiansong Chen,Haishun Du,Zhiqiang Pang,Weiqi Wei,Xuejun Pan
Furfural is a pivotal intermediate in the biomass conversion. Therefore, the production of furfural from xylose or xylose-rich biomass has received extensive attention. Herein, a series of boron phosphate solid acid catalysts (BPs) were synthesized by self-assembly and high-temperature calcination, and used for the production of furfural from xylose or xylose-rich biomass. The results showed that the synthesized BPs was spherical nanoparticles and containing both Lewis acid and Brønsted acid sites, which was excellent for xylose conversion to furfural. The maximum furfural yield of this work was 82.8 % and achieved through 95.7 % xylose conversion by using 20 mg BP 1.25 at a reaction temperature of 130 °C for 120 min with a LiBr⋅3H 2 O/dichloromethane (DCM) biphasic system. Noteworthy, the recycling experiments indicated that both the BP 1.25 catalyst and the LiBr⋅3H 2 O can be reused at least four times with a furfural yield remaining ≥61.7 %. Last but not least, the prepared BP 1.25 catalyst also displayed high efficiency for xylose-rich natural biomass such as corncob and bagasse conversion into furfural. The work not only developed a new system for easy conversion of xylose into furfural, but also realized the high yield production of furfural from natural biomass without components separation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2016
·
IF 3.15
Jie Su,Weiyuan Yao,Yue Liu,Zhongbiao Wu
A series of HZSM-5 supported CrO x catalysts at different loadings were prepared by wet impregnation method for catalytic combustion of dichloromethane (DCM) in this paper. The catalytic activity tests indicated that both DCM conversion and product selectivity varied greatly with Cr doping contents. The sample at 2 wt% loading showed the highest DCM conversion, while the selectivity toward CO/CO 2 increased at an elevated CrO x loading. The characterization results revealed that the surface acidity and the chemical states of Cr were strongly affected by the doping content. The surface acidity would decline at an elevated Cr loading owing to the interactions between surface OH groups and chromium ions. And higher surface Cr(VI)/Cr(III) ratios could be observed on the catalysts at lower CrO x doping, leading to the improvement of reducibility. The activity and selectivity of DCM catalytic degradation were found to be highly depended on the balance of surface acidity and redox property. The increased surface acidity could result in the enhancement of dissociated adsorption of DCM, which are beneficial to the catalytic activity. However, higher surface acidity meant lower Cr loading, which might lead the adsorbed intermediates incompletely oxidized and the decrease in CO x selectivity due to the limit redox ability.
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
EXPERIMENTAL ANIMALS
·
2020
·
IF 1.574
Yongxia Cheng,Jingchao Li,Chong Wang,Heran Yang,Ying Wang,Tao Zhan,Sufen Guo,Jun Liang,Yuxin Bai,Jianbo Yu,Guibo Liu
Diabetic cardiomyopathy (DCM) is one of the cardiovascular complications of diabetes mellitus independent of hypertension, coronary disease, and other heart diseases. The development of DCM is multifactorial and hard to detect at an early stage. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) is emerging as a regulator of DCM, the underlying mechanism of its role in DCM has not been elaborated yet. In this study, we established a mouse DCM model via streptozocin injection as evidenced by cell hypertrophy and cell apoptosis of myocardial tissue, and found that Malat1 expression was upregulated in the myocardium in DCM mice. Meanwhile, elevated expression of pro-apoptotic factors p53, p21, cleaved caspase 3, cleaved caspase 9 and BAX, and down-regulation of anti-apoptotic BCL-2 were observed in DCM myocardium. We further investigated the effect of Malat1 on cardiomyocytes under high glucose condition by silencing Malat1 with its specific short-hairpin RNA. Like in vivo, expression of Malat1 in cardiomyocytes was notably raised, remarkable cell apoptosis and changes in apoptosis-related factors were also observed following high glucose treatment. Besides, we validated that Malat1 acted as a sponge of miR-181a-5p. Inhibition of miR-181a-5p could, at least partially, abolish Malat1 knockdown-induced alteration in cardiomyocytes. In addition, p53, a critical regulator of apoptosis, was validated to be a downstream target of miR-181a-5p. In summary, our findings reveal that Malat1 knockdown attenuates high glucose-induced cardiomyocyte apoptosis via releasing miR-181a-5p, and this mechanism may provide us with new diagnosis target of DCM.
研究领域:
分子生物学
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心脏病学
·
糖尿病
·
非编码RNA
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产品关联
DOI
PubMed
高影响因子
Chinese Medicine
·
2025
·Vol. 20
·期 1
·1-14
·
IF 5.7
Jiang Feng,Tang Jiayang,Wei Xiaoqi,Pan Hai,Fan Xinyi,Zhang Peng,Guo Shuzhen
Background Dilated cardiomyopathy (DCM) stands as one of the most prevalent and severe causes of heart failure. Inflammation plays a pivotal role throughout the progression of DCM to heart failure, while age acts as a natural predisposing factor for all cardiovascular diseases. These two factors often interact, contributing to cardiac fibrosis, which is both a common manifestation and a pathogenic driver of adverse remodeling in DCM-induced heart failure.MethodBulk RNA-seq, single-cell RNA-seq, Mendelian randomization analysis, animal model construction, and BMP6 knockdown were utilized to identify and validate potential specific markers and targets for intervention in DCM heart failure.Results We found that DCM hearts exhibit pronounced inflammatory cell infiltration and fibrosis. Both bulk RNA-seq and single-cell RNA-seq analyses revealed aberrant BMP6 expression specifically in fibroblasts. The ROC curve underscores the high specificity of BMP6 in relation to DCM, while Mendelian randomization analysis further confirms BMP6 as a protective factor against DCM. Notably, BMP6 knockdown led to a decrease in SMAD6 expression and a marked elevation in COL1A1 expression levels, indicating its antifibrotic role.Conclusion BMP6 emerges as a promising biomarker for DCM, and its functional role in exerting an antifibrotic effect underscores its potential as a therapeutic target.
研究领域:
心脏病学
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分子生物学
·
基因组学
·
医学遗传学
✓ 已验证
DOI
PubMed
高影响因子
Nature Protocols
·
2024
·
IF 13.1
Chen Chao,Zhang Xiaoyan,Gao Zhiyuan,Feng Guangxue,Ding Dan
Fluorescence imaging represents a vital tool in modern biology, oncology and biomedical applications. Afterglow luminescence (AGL), which circumvents the light scattering and tissue autofluorescence interference associated with real-time excitation source, shows remarkably increased imaging sensitivity and depth. Here we present a protocol for the design and synthesis of AGL nanoprobes with an aggregation-induced emission (AIE) effect to simultaneously red shift and amplify the afterglow signal for tumor imaging and image-guided tumor resection. The nanoprobe (AGL AIE dot) is composed of an enol ether format of Schaap’s agent and a near-infrared AIE fluorogen (AIEgen) (tetraphenylethylene-phenyl-dicyanomethylene-4H-chromene, TPE-Ph-DCM) to suppress the nonradiative dissipation pathway. Pre-irradiating AGL AIE dots with white light could generate singlet oxygen to convert Schaap’s agent to its 1,2-dioxetane format, thus initializing the AGL process. With the aid of AIEgen, the AGL shows simultaneously red shifted emission maximum (from ~540 nm to ~625 nm) and enhanced intensity (by 3.2-fold), facilitating better signal-to-background ratio, imaging sensitivity and depth. Intriguingly, the activated AGL can last for over 10 days. Compared with conventional approaches, our method provides a new solution to concurrently red shift and amplify afterglow signals for better in vivo imaging outcomes. The preparation of AGL AIE dots takes ~2 days, the in vitro characterization takes ~10 days (less than 1 day if not involving afterglow kinetic profile study) and the tumor imaging and image-guided tumor resection takes ~7 days. These procedures can be easily reproduced and amended after standard laboratory training in chemical synthesis and animal handling.
研究领域:
生物医学工程
·
肿瘤学
·
生物成像
·
纳米技术
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 36
·7538-7546
·
IF 4.543
Peilian Liu,Bowen Li,Chenyue Zhan,Fang Zeng,Shuizhu Wu
A light-activated cleavage strategy for the concomitant release of active drugs and generation of fluorescence changes is highly desirable. Herein a molecular prodrug featuring real-time monitoring of drug localization and release by manipulating fluorophores has been created by constructing a cleavable structure which comprises a photoremovable coumarinyl, an anticancer drug camptothecin, a cleavable linker and a near infrared fluorescent dye dicyanomethylene-4H-pyran (DCM). The fluorescence of coumarinyl and CPT is completely quenched by the DCM moiety via fluorescence resonance energy transfer (FRET). The internalization of the prodrug by cells and its subsequent intracellular location can be tracked by collecting the red fluorescence of DCM; while the release of active CPT as a result of one- or two-photon irradiation can be monitored by observing the newly emerged fluorescence of CPT under one- or two-photon excitation. The prodrug also shows highly controllable cytotoxicity toward HeLa cells and A549 cells, with low IC50 values of 4.01 and 2.53 μM, respectively, upon light irradiation and with much higher IC50 values (>40 μM) without light irradiation. This strategy may provide an approach for the development of light-activatable theranostic anticancer therapeutics.
研究领域:
药学
·
癌症研究
·
生物医学工程
·
光化学
·
诊疗一体化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）