JOURNAL OF SOLUTION CHEMISTRY
·
2022
·Vol. 51
·期 10
·1199-1208
·
IF 2
Wu Jieyu,Yin Tianxiang,Wang Xiaoyong
Deep eutectic solvents (DES), as a new type of green solvent, show great advantages of easy preparation and no need of purification after synthesis and great potential applications in various fields. Osthole has shown wide variety of pharmacological functions like antimicrobial, anti-inflammatory, antioxidant, or anti-cancerous. To explore the efficient delivery of osthole, we have designed a new DES based on osthole and DL-menthol with molar ratio of 1:15. The interaction between osthole and DL-menthol was checked and verified by 1 HNMR and FT-IR spectra. The physicochemical properties and anti-bacterial activity of the DES were investigated. Low viscosity and higher anti-bacterial activity against S. aureus make the DES suitable for the dermal or transdermal delivery of osthole. Therefore, the results presented herein indicated that DES may serve as a new strategy for the application of active pharmaceutical ingredients.
研究领域:
药学
·
材料科学
·
化学
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高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Yan Ma,Junhong Zhou,Zhaohua Miao,Haisheng Qian,Zhengbao Zha
Cancer cells with up-regulated intracellular heat shock proteins (HSPs) expression under adverse heat environment during photothermal therapy (PTT) always resulted in inefficient oncotherapy. As the expression of HSPs is an energy-dependent manner, inhibiting the aerobic glycolysis pathway to realize tumor starvation and therefore consequently reducing the production of intratumoral adenosine 5′-triphosphate (ATP) would offer an efficient way for sensitizing cancer cells to PTT. DLM@PPy NPs, a polypyrrole (PPy)-based platform complexing with dl-menthol (DLM), was well-designed and successfully developed here as a near-infrared (NIR) light and thermo responsive drug delivery system. Benefiting from the volatile property of DLM and high photothermal conversion ability of PPy, the as-prepared DLM@PPy NPs could continuously generate bubbles under NIR light illumination, which is good for precisely controlling the release of encapsulated drug and monitoring the whole therapeutic process by ultrasound imaging. By encapsulating diclofenac (DC, an inhibitor of glucose transporter 1 to realizing tumor starvation) to form DC/DLM@PPy NPs, on-demand DC release could be easily achieved by selectively turning on/off the NIR light irradiation. After releasing DC in tumor lesion to reduce the generation of intratumoral ATP, a significant intensified cell-killing efficiency of PTT was observed. Thus, our study has demonstrated the good potential of DLM/PPy NPs as a stimuli-responsive DC delivery system for intensified PTT through inhibiting the aerobic glycolysis of cancer cells.
研究领域:
癌症治疗
·
纳米技术
·
药学
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生物医学工程
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PubMed
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yan Zhou,Xujing Dong,Xiaoyi Tian,Shuai Wang,Fanqing Meng,Jianguang Qi,Yinglong Wang,Ekemini Ituen
Adipic acid is used as a chemical feedstock to produce high-value products such as nylon, polyester, and plasticisers. However, the production process generates highly acidic wastewater containing adipic acid and its by-product, glutaric acid. Traditional treatment methods are often inefficient or environmentally harmful. In this study, four deep eutectic solvents (DES) were synthesized using tributyl phosphate (TBP) and trioctylphosphine oxide (TOPO) as the raw materials, combined with 1-octanol and DL-menthol. The extraction process was optimized through comprehensive experimentation and molecular simulation. TOPO/DL-menthol DES achieved 97 % recovery of adipic acid and 87 % recovery of glutaric acid within a single 5-min extraction step at 20 °C. This extractant demonstrated exceptional reusability, with structural stability confirmed through characterization. The extraction mechanisms were elucidated via thermodynamic studies, quantum chemical calculations, and molecular dynamics simulations. This study provides a green and recyclable solution for the recovery of carboxylic acids.
研究领域:
环境化学
·
绿色化学
·
分离科学
·
分子模拟
·
化学工程
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2026
·
IF 4
Mengting Fu,Huimin Zhang,Mengting Cui,Jinling Bai,Zhiyu Liu,Zhixin Ouyang,Liyun Kong
A green HDES-based TA-DLLME was developed for PAEs analysis in beverages. • Optimized method achieved high preconcentration factors and low detection limits. • COSMO-RS and DFT studies revealed strong hydrogen-bonding interactions. • Sample analysis detected PAEs in beverages meeting national food safety standards. The quantification of phthalic acid esters (PAEs) in food and beverages is crucial for assessing human exposure levels. In this study, an environmentally benign microextraction methodology was developed utilizing a thymol-butyric acid deep eutectic solvent (DES) for the sensitive determination of six PAEs in beverage samples. Through systematic optimization, the temperature-assisted dispersive liquid-liquid microextraction (TA-DLLME) protocol achieved high enrichment factors (82.01–112.39) and extraction recoveries (66.94%-91.75%). Low detection limits (1.14–4.85 μg/L) were achieved, when coupled with HPLC-PDA analysis. The validated method was successfully applied to commercial beverages, with PAEs detected in 78.6% of samples at concentrations ranging from 4.04 to 47.1 μg/L. Mechanistic investigations through COSMO-RS and DFT calculations revealed that strong hydrogen-bonding interactions between the DES components and PAEs (ΔE = -17.29 to -26.28 kcal/mol) are the primary driver of the high extraction efficiency. With the advantages of low solvent consumption (≤200 μL) and rapid processing (<15 min), this approach provides a sustainable and practical alternative for routine monitoring of PAEs in liquid food products. Download: Download high-res image (136KB) Download: Download full-size image
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
He Yijing,Yang Yue,Wang Huixi,Zhang Fan,Cai Wentao,Yu Haixiang,Di Bin
Dextromethorphan (DXM) is a widely used cough suppressant,
and
its escalating abuse is a pressing global health concern that necessitates
rapid screening tools. However, rapid methods for detecting DXM in
complex matrices remain highly limited. Here, we report the first
isolation and engineering of DNA aptamers specifically targeting DXM.
Using library-immobilized SELEX, we identified high-affinity aptamers
( K D ∼ 1–2 μM) with
exceptional specificity against various interferents. The lead candidate
was rationally truncated into a minimal 27-nucleotide core (DM1–27)
that retains full function. Systematic mutagenesis and molecular modeling
further delineated the structure–activity relationship governing
target recognition. Utilizing this engineered aptamer, we developed
two distinct fluorescent platforms: a label-free thioflavin T displacement
assay and a fluorophore-quencher labeled hybrid beacon. Both sensors
enabled robust DXM quantification within 10 min in human saliva and
e-cigarette juice (EJ), achieving limits of detection at low ng/mL-level.
Notably, the hybrid beacon significantly improved matrix tolerance
by bypassing short-wavelength background interference. This work provides
a versatile molecular recognition tool and establishes practical,
field-deployable sensing strategies for DXM monitoring.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yalu Liu,Zhenpeng Wang,Yapeng Zhang,Jiutao Hu,Sen Huang,Bin Hao,Xiaobo Huang
Gel-based conductors have attracted great attention in the field of wearable sensors, due to their flexibility and electrical conductivity. However, these properties of gels are often severely compromised by water molecules, leading to functionality failure in humid or underwater environments. In this study, a hydrophobic eutectogel (PHAEL) is rapidly synthesized via photopolymerization. The preparation involved simultaneously introducing hydrophobic and hydrophilic monomers into a deep eutectic solvent composed of decanoic acid and menthol (DecA/Men). Due to the abundant covalent and hydrophobic interactions within the polymer network, the synthesized PHAEL addresses the shortcomings of conventional eutectogels that are sensitive to water, while enabling good reliable strain-sensing properties both in air and underwater. PHAELs also exhibit high transparency, tunable mechanical properties, and good adhesion. Utilizing digital light processing (DLP) 3D printing technology, the eutectogel can be fabricated into various flexible sensors with intricate structures. These sensors enable underwater Morse code transmission, making them suitable for communication applications. In summary, the design of gels presents new opportunities to develop flexible wearable sensor devices suitable for underwater and extreme environments.
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JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Xiaoyan Jiang,Renxiu Huang,Guohua Zhu,Lingqi Shen,Panfei Li,Xuerong Yang,Fangxi Xu,Zuguang Li
As a growing concern in aqueous systems, liquid crystal monomers (LCMs), have been widely detected in the environment and organisms, posing a potential threat to ecosystems and human health. Conventional liquid-liquid extraction methods based on organic solvents are operationally complex, time-consuming, and environmentally unfriendly. Switchable deep eutectic solvents (SDESs) have emerged as environmentally friendly solvents have shown promise for extracting pollutants from water for detection. Herein, an ultrasound-assisted homogeneous liquid-liquid microextraction (UA-HLLME) method coupled with pH-responsive switchable deep eutectic solvents (SDESs) for extracting LCMs from environmental water samples was established. We validated the established method by gas chromatography-mass spectrometry (GC-MS), and excellent linearity (R²≥0.9984) were obtained across a concentration range of 2.5-500 ng·mL⁻¹. The limits of detection (LODs) ranged from 0.09 to 0.66 ng·mL⁻¹, and the limits of quantification (LOQs) were 0.30-2.21 ng·mL⁻¹. Satisfactory recoveries (88.32%-127.79% for artificial lakes and 94.73%-134.73% for rivers) and enrichment factors (12-19) were obtained in environmental water samples. The method enhanced the preconcentration efficiency and have advantages of operational simplicity, high efficiency and environmental friendliness. This work lays a foundational basis for the future development of innovative SDES-UA-HLLME based technologies in the detection of LCMs in environmental matrices.
研究领域:
环境科学
·
分析化学
·
污染物检测
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绿色化学
·
水体生态安全
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PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Yuxin Liu,Chenjie Ma,Mantang Chen,Jufang Hao,Wei Liu,Jingjing Yu
Pyrethroid insecticides (PYs) overuse poses ecological and health risks, leading to tightened restrictions on maximum residue limits (MRLs) by regulatory bodies like the European Union and China's National Food Safety Standards. It is important to develop multi-residue analytical methods for PYs residues. In present work, oleic acid-coated Fe 3 O 4 nanoparticles (Fe 3 O 4 -OA) were dispersed in hydrophobic deep eutectic solvents (HDES) to prepare ferrofluids (FFs), with the HDES synthesized from coumarin and thymol at a 1:2 molar ratio. And the HDES-FF was subsequently utilized as a vortex-assisted liquid-phase microextraction sorbent for the enrichment of 16 PYs, combined with GC–MS/MS analysis. HDES-FF could effectively enrich PYs within merely 3.5 min according to π-π stacking interactions and hydrophobic effects, while Fe 3 O 4 -OA nanoparticles were responsible for magnetic separation. It could successfully solve the problem of separation difficulty after liquid-liquid microextraction based on DES. Simultaneously, thermogravimetric analysis confirmed that the HDES could decompose at injection port of GC–MS/MS instrument, and mass spectrometry signals of the decomposed HDES could not be collected by adjusting the solvent delay time. Thus, it could effectively protect the ion source from contamination, making DES compatible with GC–MS methods. The detection limit (LOD) of the proposed method is 0.41–7.91 ng/mL, with the recoveries of 83.33–106.02 %. The intra-day and inter-day relative standard deviations (RSDs) are less than 4.20 % and 6.94 %, respectively. The method successfully detected 16 PYs in various real fruit and vegetable samples.
研究领域:
食品安全检测
·
农药残留分析
·
食品化学
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PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Jiaze Yan,Chao Jiang,Jiqi Zheng,Ming Guo
Background Microdialysis is an in vivo technique for dynamically analyzing biochemical components in tissues and fluids. Traditional microdialysis systems are primarily designed for low molecular weight polar compounds, resulting in lower recoveries for hydrophobic compounds. This study aimed to develop a greener, cost-effective, and enhanced microdialysis method for recovering eugenol, isoeugenol, and methyl isoeugenol, utilizing hydrophobic deep eutectic solvents as the perfusate, with the method's feasibility verified through in vivo experiments. Results Among the 19 types of deep eutectic solvents evaluated, thymol-levulinic acid was identified as the most suitable for eugenol compounds based on liquid-liquid microextraction and microdialysis experiments, showing an in vitro microdialysis recovery approximately 100 times higher than that of water. The optimization of microdialysis parameters was conducted, including molar ratio of HBA:HBD, temperature, flow rate, and semi-permeable membrane length. In the in vivo microdialysis experiments, the temporal concentration of eugenol, which was used as an anesthetic in Glyptocidaris crenularis, was detected by GC-MS/MS and calibrated using ex vivo recovery. When the concentration of eugenol in artificial seawater was maintained at 100 μg mL −1 , the eugenol levels in the coelomic fluid of Glyptocidaris crenularis rose from 0 to 6.89 ± 0.38 μg mL −1 within 60 min, then stabilized in next 80 min. Significance The findings demonstrate that deep eutectic solvents enhanced microdialysis provides high recoveries and enables real-time monitoring of drug concentration changes in biological systems, making this method a valuable tool for pharmacokinetic studies and environmental monitoring.
研究领域:
分析化学
·
药理学
·
海洋生物学
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Zixing Zhang,Yuxin Xu,Yun Hu
To enhance the mechanical properties and water resistance of chitosan (CS) films while imparting additional functionalities, this study incorporated a hydrophobic deep eutectic solvent (DES) composed of menthol and pyruvic acid into the CS matrix. At an optimal DES content of 15 %, compared to pure CS films, the elongation at break increased by 77 %, while swelling degree and solubility decreased by 94.44 % and 60.71 %, respectively. The lowest water vapor permeability (11.55 × 10 −11 g·m −1 ·s −1 ·Pa −1 ) demonstrated enhanced moisture barrier properties. These improvements were attributed to the synergistic effects of hydrogen bonding and ionic crosslinking, reinforcing the network structure and restricting water penetration while maintaining molecular mobility. The films also exhibited excellent ultraviolet-shielding (ultraviolet C transmittance of 3 %) with high transparency, making them suitable for light-sensitive packaging. Additionally, they achieved complete biodegradation in soil within 10 weeks, highlighting their potential as sustainable alternatives to petroleum-based plastics. This study presents a novel approach to enhancing bio-based packaging materials through hydrophobic DES, expanding their applications in sustainable food and pharmaceutical packaging.
研究领域:
材料科学
·
食品科学
·
环境科学
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DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2026
·
IF 2.1
Minjie Gao,Congfei Zhu,Yasen Dai,Bingru Wang,Shuhang Ren,Weize Wu
Deep eutectic solvents (DESs) show great potential in the field of CO2 capture; however, the lack of systematic physicochemical property data remains a bottleneck constraining their rational design and industrial application. This study prepared six representative DESs and systematically characterized their key fundamental properties as absorbents: density, viscosity, thermal stability, and specific heat capacity. The results indicate that the chemical structure of the hydrogen bond acceptor has a decisive influence on the properties of the DESs. The viscosity and density of all DESs decreased significantly with increasing temperature. Thermogravimetric analysis revealed their varying thermal stabilities, with the onset decomposition temperature ranging from 366.52 K (menthol–ethylene glycol) to 415.17 K (choline chloride–ethylene glycol). The measurement of specific heat capacity data provides a key basis for evaluating solvent regeneration energy consumption. This study fills the gap in systematic property data of various DESs. Comprehensive analysis indicates that the choline chloride-ethylene glycol system achieves the best balance among viscosity, thermal stability, and specific heat capacity, making it a highly promising candidate based on its physicochemical property profile for CO2 capture among the studied systems. This work provides solid data support and theoretical guidance for the screening, design, and energy optimization of DESs in CO2 capture processes.
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高影响因子
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
·
2020
·Vol. 31
·期 10
·2120-2128
·
IF 1.399
Ge Dandan,Gao Ying,Cao Yunxin,Dai Enrui,Yuan Lin
A vortex-assisted liquid-liquid microextraction method combined with high performance liquid chromatography-diode array detector has been developed for the determination of parabens in foods, cosmetics and pharmaceutical products. In this work, polymeric deep eutectic solvents composed of DL-menthol and polyethylene glycol with three different light grades were prepared successfully for the first time and used as extraction solvents. The influencing parameters on the extraction efficiency including type of extraction solvent, salt addition, composition of deep eutectic solvent, volume of extraction solvent, extraction time and solution pH were evaluated. Under the optimized conditions, using DL-menthol and polyethylene glycol 400 at a molar ratio of 1:1 as the extraction solvent, the method exhibited good linearity with linear coefficients greater than 0.9995. Limits of detection and limits of quantification were in the range of 0.3-2 ng mL-1 and 1-5 ng mL-1, respectively. The proposed method was successfully applied to determine four parabens in seven commercial products. The proposed method is simple, green and efficient, and could be applied to determine parabens in complex matrices.
研究领域:
分析化学
·
环境科学
·
食品科学
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高影响因子
危险品化学品经营许可证（带存储）