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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS · 2018 · IF 2.829

Carbon nanotubes modified by a paramagnetic cationic surfactant for migration of DNA and proteins

Lu Xu,Lei Feng,Shuli Dong,Jingcheng Hao,Qun Yu

We report the fabrication of magnetic carbon nanotubes (MCNTs) through one-step modification with a paramagnetic cationic surfactant for migration of DNA and proteins. DNA and proteins can effectively bind to the surfactant-coated MCNTs through electrostatic interaction. Targeted transport platform of DNA and proteins as delivery agents can be constructed upon application of an external magnetic field. The native conformation of these biomacromolecules can be suitably maintained without denaturation during the migration process. We expect it will find MCNTs potential applications in gene delivery, gene transfection, protein delivery and separation.

CAS / MDL: 308068-56-6 18618-55-8

研究领域: 生物物理学 · 分子生物学 · 纳米医学

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CHEMICAL RESEARCH IN TOXICOLOGY · 2018 · IF 3.432

Polybrominated Diphenyl Ethers Quinone Induced Parthanatos-like Cell Death through a Reactive Oxygen Species-Associated Poly(ADP-ribose) Polymerase 1 Signaling

Wenjing Dong,Bingwei Yang,Yawen Wang,Jia Yuan,Yunqi Fan,Erqun Song,Yang Song

Polybrominated diphenyl ethers (PBDEs) are emerging organic environmental pollutants, which were accused of various toxic effects. Here, we studied the role of a potential PBDEs quinone metabolite, PBDEQ, on cytotoxicity, oxidative DNA damage, and the alterations of signal cascade in HeLa cells. PBDEQ exposure leads to reactive oxygen species (ROS) accumulation, mitochondrial membrane potential (MMP) loss, lactate dehydrogenase (LDH) release, increasing terminal transferase-mediated dUTP-biotin nick end labeling (TUNEL) positive foci, and the elevation of apoptosis rate. Furthermore, we showed PBDEQ exposure result in increased DNA migration, micronucleus frequency, and the promotion of 8-OHdG and phosphorylation of histone H2AX (γ-H2AX) levels. Mechanism study indicated that PBDEQ caused poly(ADP-ribose) polymerase 1 (PARP-1) activation and apoptosis-inducing factor (AIF) nuclear translocation. All together, these results confirmed the occurrence of parthanatos-like cell death upon PBDEQ exposure.

CAS / MDL: 67-68-5 68-12-2 615-58-7

研究领域: 毒理学 · 细胞生物学 · 环境科学 · 分子生物学

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Carbon nanotubes modified by a paramagnetic cationic surfactant for migration of DNA and proteins

Polybrominated Diphenyl Ethers Quinone Induced Parthanatos-like Cell Death through a Reactive Oxygen Species-Associated Poly(ADP-ribose) Polymerase 1 Signaling