MINERALS ENGINEERING
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2021
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IF 4.765
Jie Liu,Xun Wang,Yimin Zhu,Yuexin Han
The selective separation of scheelite from fluorite is difficult because of their similar surface properties. In this study, diethylenetriaminepentaacetic acid (DTPA) was used as a novel depressant for the efficient removal of fluorite from scheelite, and its depression effect and mechanism were systematically investigated by conducting micro-flotation experiments and a series of surface analyses. The micro-flotation experiments showed that the floatability of fluorite was significantly reduced by DTPA, whereas that of scheelite was minimally affected. Zeta potential measurements revealed that DTPA selectively adsorbed on fluorite surface and decreased the zeta potentials, whereas the zeta potentials of scheelite were negligibly influenced by DTPA. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy further proved that the interaction between DTPA and the fluorite surface was chemisorption, and in the adsorption configuration, the carboxyl groups of DTPA chelated with Ca sites on the fluorite surface. Additionally, an electrical analysis showed that electrostatic attraction facilitated the adsorption of DTPA on the fluorite surface. The adsorption of DTPA on fluorite surface could strongly inhibit the further adsorption of NaOL on fluorite surface, and therefore significantly depressed the floatability of fluorite. In contrast, the interaction between DTPA and scheelite was very weak and was impeded by steric hindrance caused by WO 4 2- and electrostatic repulsion. Therefore, DTPA has the potential to act as a depressant for the effective separation of scheelite from fluorite.
研究领域:
矿物加工工程
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表面化学
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产品关联
DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2018
·Vol. 319
·期 1
·69-73
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IF 1.181
Duan Xiaoyan,Li Jianbo,Lu Xiaoling
In the field of nanotechnology, DNA-based nanoscale materials have facilitated the construction of DNA polyhedrons with different shapes and sizes by using predictable base pairing and highly tunable conformation. In this study DNA bipyramid nanostructures with one arm chain (T20-DBNs) were successfully prepared in a single annealing procedure. 99m Tc-A20 ssDNA was obtained by radiolabeled DTPA-A20 with 99m Tc, and then 99m Tc-DTPA-DBNs were obtained by hybridizing T20-DBNs with 99m Tc-A20 ssDNA. We focused on studying a method of 99m Tc radiolabeling DNA nanostructures with DTPA as a chelate, and hoped to develop a new SPECT molecular imaging probe based on DNA nanostructures.
研究领域:
纳米技术
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放射医学
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分子影像学
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DOI
高影响因子
RUSSIAN JOURNAL OF APPLIED CHEMISTRY
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2016
·Vol. 89
·期 7
·1145-1157
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IF 0.307
Yu Ting,Yang Xu,Yuan Jianlan,Guo Li,Wu Xiaoling,Wang Hao
In drilling and production process, the barite powder serving as weighting agent is added to ensure operation safety when overflow occurs, that results in reservoir pollution and pore blockage. The main component of barite is BaSO 4 , so ammonium carboxy chelating agents can be injected into formation to form stable chelates with Ba 2+ , BaSO 4 will be eliminated from wellbore with flowback fluid easily. In this experiment, the weight method and the atomic absorption spectrometry method were utilized to study descaling ability and an action mechanism of descaling agents. Firstly, DTPA was selected from three descaling agents: NTA, EDTA, DTPA; then OT1 was screened out to synergize with DTPA and studied its descaling mechanism; eventually, the descaling system STD was determined, and its composition was 6% DTPA + 5% OT1 + 1% antiswelling agent + 100 ppm corrosion inhibitor. And the STD’s performance evaluation experiment results suggested that it had an excellent resistance to temperature and demonstrated a good descaling ability at 170°C. Furthermore, the descaling ability of STD was almost not affected by calcium and magnesium ions and its corrsion rate is lower than standard value. Moreover, STD could descale efficiently at lower dosage. So STD can be widely applied to descale in oilfield.
研究领域:
石油工程
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化学工程
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DOI
高影响因子
BIOMATERIALS
·
2019
·
IF 10.273
Weihua Liao,Peng Lei,Jinbin Pan,Cai Zhang,Xianting Sun,Xuejun Zhang,Chunshui Yu,Shao-Kai Sun
Clinically used iodinated computer tomography (CT) contrast agents suffer from low sensitivity, and the emerging lanthanide-chelates and CT imaging nanoagents raise great safety concerns. The fusion of high sensitivity and good biocompatibility is highly desired for the development of CT contrast agents. Herein, we propose a facile and green one-pot synthesis strategy for the fabrication of a small molecular CT contrast agent, Bi-diethylene triamine pentaacetate acid (DTPA) complex, for high-performance CT and spectral CT imaging. The Bi-DTPA exhibits yield of near 100%, outstanding water solubility, favorable biocompatibility, large-scale production capability, and superior X-ray attenuation ability, and is successfully applied in high-quality in vivo kidney imaging and gastrointestinal tract CT imaging and appealing spectral CT imaging. The proposed contrast agent can be rapidly excreted from body, avoiding the potential side effects caused by the long-term retention in vivo. Furthermore, our design shows great potential in developing diverse multifunctional contrast agents via chemical modification. The proposed Bi-DTPA with unique superiorities shows a bright prospect in clinic CT imaging, especially spectral CT imaging, and lays down a new way for the design of high-performance CT contrast agents with great clinical transformation potential.
研究领域:
医学影像学
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生物医学工程
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放射医学
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DOI
高影响因子
Nanomaterials
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2015
·Vol. 5
·期 3
·1379-1396
·
IF 2.076
Li Zhang,Tingxian Liu,Yanan Xiao,Dexin Yu,Na Zhang
Molecular imaging is essential to increase the sensitivity and selectivity of cancer diagnosis especially at the early stage of tumors. Recently, polyionic nanocomplexes (PICs), which are composed of polyanions and opposite polycations, have been demonstrated to be a promising strategy for biomedical applications. In this work, chitosan-hyaluronic acid nanoparticles (GCHN) were developed to deliver Gd-DTPA as MRI contrast agents for tumor diagnosis. The Gd-labeled conjugates (CS-DTPA-Gd) were successfully synthesized by carbodiimide reaction, and then GCHN were prepared by ionic gelation using the obtained CS-DTPA-Gd and hyaluronic acid. The morphology of GCHN was spherical or ellipsoidal, which is observed by transmission electronic microscopy (TEM). The mean particle size and zeta potential of GCHN were 213.8 ± 2.6 nm and 19.92 ± 1.69 mV, respectively. The significant enhancement of signal intensity induced by GCHN was observed bothin vitroandin vivo. Also, compared with Magnevist, GCHN was witnessed for a prolonged imaging time in the B16 tumor-bearing mice model. Furthermore, GCHN were verified as below toxic bothin vitroandin vivo. These results indicated that GCHN could potentially be an alternative to current MRI contrast agents for tumor diagnosis.Keywords:tumor imaging;magnetic resonance imaging;hyaluronic acid;chitosan nanoparticles;Gd-DTPA
研究领域:
医学影像学
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生物材料学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Guowei Shan,Xiao Xiao,Hong Gao,Qi Zhang,Houyi Peng,Weixing Li
Heavy metal ion (HMI)-contaminated wastewater is a great threat to public health. Membrane separation is an efficient and green technology for HMI removal. Here, the strategy of nanoparticle in-situ growth combined with molecule grafting was proposed to fabricate the UiO-66-NH 2 -g-DTPA/PES composite membrane. The UiO-66-NH 2 nanoparticles bound within the PES membrane substrate uniformly brought a significant number of primary amino groups, providing abundant graft sites for DTPA molecule. Numerous carboxyl groups and tertiary amine groups were introduced as the result of DTPA grafting, enabling the formation of M−DTPA complexes with HMIs. The fabricated UiO-66-NH 2 -g-DTPA/PES membranes exhibited excellent performances. The pure water flux arrived at 6208 L·m −2 ·h −1 and the efficiencies of removing Cu 2+ , Pb 2+ , Cr 3+ and Cd 2+ were 99.73%, 99.79%, 96.91% and 98.33%, respectively. Moreover, the UiO-66-NH 2 -g-DTPA/PES membrane also showed a remarkable stability in pH conditions ranging from 3 to 10 and remained a relatively high performance in the cyclic test.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2012
·Vol. 41
·期 28
·8723-8728
·
IF 3.838
Zengchen Liu,Bo Li,Baodui Wang,Zhengyin Yang,Qin Wang,Tianrong Li,Dongdong Qin,Yong Li,Mingfang Wang,Mihui Yan
In the present study, we report new water-soluble cell fluorescence imaging and contrast agents that are based on DTPA-AMC(7-amino-4-methyl coumarin)-Eu3+ and DTPA-AMC(7-amino-4-methyl coumarin)-Gd3+ compounds conjugated to Fe3O4 NPs via a PEG-NH2 linker. The novel Fe3O4 NP-conjugates present two main advantages for cell fluorescence labelling: water solubility and targeting ability. The in vitro experiments demonstrate that water-soluble Fe3O4 NPs-DBI-PEG-NH-DTPA-AMC(7-amino-4-methyl coumarin)-Eu3+ has excellent cell permeating activity. Moreover, the relaxation rate test of Fe3O4 NPs-DBI-PEG-NH-DTPA-AMC(7-amino-4-methyl coumarin)-Gd3+ shows a higher T1 relaxation effect than traditional DTPA-Gd3+ MRI agents. According to in vivo liver MRI experiments, better contrast of the liver was achieved after addition of Fe3O4 NPs-DBI-PEG-NH-DTPA-AMC(7-amino-4-methyl coumarin)-Gd3+. The results will provide a significant guide for researchers exploring the biomedical applications of superparamagnetic Fe3O4 NPs.
研究领域:
生物医学工程
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分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2024
·
IF 4.4
Haijiao Jia,Xinyu Xu,Yuchen Cui,Mengqi Cheng,Guirong Borjihan,Xiao Zhang,Shengbo Yang,Youxin Li
A novel magnetic heterogeneous ruthenium catalyst (Fe 3 O 4 @SiO 2 -DTPA-Ru) was prepared by using magnetic silicon spheres as support, ethylenediaminepentaacetic acid (DTPA) as functional ligands, ruthenium chloride as catalyst precursor. The results obtained after a series of characterizations showed that the catalyst Fe 3 O 4 @SiO 2 -DTPA-Ru was 5–15 nm in size with a 0.205 nm lattice and contained 0.31 mmol Ru/g catalyst. It also had a good thermal stability under 232°C which was verified by thermal filtration method. Besides, the saturation magnetic intensity was as high as 20.54 emu/g. The catalyst Fe 3 O 4 @SiO 2 -DTPA-Ru was applied for the first time into thirteen oxidation reactions of aromatic alcohols and showed good catalytic activity even the yields of eleven aromatic alcohols were all over 90%. In catalyzing 1-phenylethanol to acetophenone, its TOF and TON were 9677 h −1 and 6991, respectively. The Fe 3 O 4 @SiO 2 -DTPA-Ru catalyst could still maintain good reusability and catalytic performance after 15 cycles of 1-phenylethanol oxidation, which was superior to many reported catalysts and had great potential in future industrial production.
研究领域:
化学
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催化材料科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Jing Gao,Li Zhang,Shejiang Liu,Xiuli Liu
Copper contamination of water is one of the most pressing environmental problems which has attracted extensive concern in recent decades. In this study, a series of magnetic adsorbents were synthesized by two-step modified cellulose with N-[3-(trimethoxysilyl)propyl]ethylenediamine (KH-792) and diethylenetriaminepentaacetic acid (DTPA) using for removal of Cu(II) from aqueous solutions. Adsorption performance of Cu(II) was systematically investigated under various treatment conditions as the effect of solution pH, contact time, initial concentration and temperature. The adsorption process was found to match better with the pseudo-second-order kinetics model, and the equilibrium adsorption data were well described by Langmuir model, which meant predominant governance of monolayer chemical adsorption. The analysis of FTIR and XPS confirmed the possible adsorption mechanism between Cu(II) and the synthesized adsorbents was electrostatic attraction and the chemical coordination. Compared with MCCs and APMC, DPMC showed higher adsorption capacity of Cu(II), reaching maximum adsorption capacity of 298.62 mg·g −1 at pH 6. Given this, ease of preparation, low cost and excellent reusability, DPMC will be promising adsorbent for application in Cu(II) removal from wastewater.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2013
·
IF 3.463
Yan Xiao,Huafang Zhang,Zhaoguo Zhang,Mina Yan,Ming Lei,Ke Zeng,Chunshun Zhao
For the purposes of obtaining a hepatocyte-selective drug delivery system, a novel tetravalent galactosylated diethylenetriaminepentaacetic acid-distearoyl phosphatidylethanolamine (4Gal-DTPA-DSPE) was synthesized. The chemical structure of 4Gal-DTPA-DSPE was confirmed by proton nuclear magnetic resonance and mass spectrometry. The four galactose-modified liposomes (4Gal-liposomes) were prepared by thin-film hydration method, then doxorubicin (DOX) was encapsulated into liposomes using an ammonium sulfate gradient loading method. The liposomal formulations with 4Gal-DTPA-DSPE were characterized by laser confocal scanning microscopy and flow cytometry analysis, and the results demonstrated that the 4Gal-liposomes facilitated the intracellular uptake of DOX into HepG2 cells via asialoglycoprotein receptor-mediated endocytosis. Cytotoxicity assay showed that the cell proliferation inhibition effect of 4Gal-liposomes was higher than that of the conventional liposomes without the galactose. Additionally, pharmacokinetic experiments in rats revealed that the 4Gal-liposomes displayed slower clearance from the systemic circulation compared with conventional liposomes. The organ distributions in mice and the study on frozen sections of liver implied that the 4Gal-liposomes enhanced the intracellular uptake of DOX into hepatocytes and prolonged the circulation. Taken together, these results indicate that liposomes containing 4Gal-DTPA-DSPE have great potential as drug delivery carriers for hepatocyte-selective targeting.
研究领域:
药剂学
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分子生物学
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药物代谢动力学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xueling Liu,Yajing Wang,Xiaofen Wu,Yi Wang,Guozhi Fan,Yanjun Huang,Lei Zhang
In this study, magnetic DTPA-modified chitosan composite microspheres (MDCM) were prepared by reverse emulsion-double crosslinking method (carbodiimide followed by glutaraldehyde) for removal of Pb(II) from aqueous solution. The obtained magnetic adsorbents were characterized by FTIR, SEM, XRD, VSM, BET, and 13 C NMR. The effects of the pH, contact time, initial concentration, and competitive metal cations (Na(I), Ca(II), or Mg(II)) on Pb(II) adsorption were investigated. The results revealed that MDCM exhibited high removal performance over a wide pH range and in the presence of competitive metal cations. The maximum adsorption capacity of MDCM for Pb(II) is 214.63 mg g −1 at pH 3, which is higher than most recently reported magnetic adsorbents. Adsorption kinetics and isotherms can be described by the pseudo-second-order model and Langmuir model, respectively. In addition, MDCM is easy to regenerate and can be reused five cycles with high adsorption capacity. Finally, the adsorption mechanism was further revealed by FTIR and XPS analysis. Overall, MDCM has practical application potential in removing Pb(II) from contaminated wastewater due to its high adsorption efficiency, good reusability, and convenient magnetic separation.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Regenerative Biomaterials
·
2024
·
IF 5.6
Ma Li,Pan Jinbin,Shu Gang,Pan Haiyan,Li Jingang,Li Dong,Sun Shaokai
Enhanced computed tomography (CT) imaging with iodinated imaging probes is widely utilized for the diagnosis and evaluation of various liver diseases. However, these iodine-based imaging probes face intractable limitations including allergic reactions and contraindications. Herein, we propose the utilization of renal-clearable iodine-free bismuth chelate (Bi-DTPA dimeglumine) for the non-invasive fast assessment of hepatic ischemia–reperfusion injury (HIRI) via CT imaging for the first time. Bi-DTPA dimeglumine offers several advantages such as simple synthesis, no purification requirement, a yield approaching 100%, large-scale production capability (laboratory synthesis > 100 g), excellent biocompatibility and superior CT imaging performance. In a normal rat model, the administration of Bi-DTPA dimeglumine resulted in a significant 63.79% increase in liver CT value within a very short time period (30 s). Furthermore, in a HIRI rat model, Bi-DTPA dimeglumine enabled the rapid differentiation between healthy and injured areas based on the notable disparity in liver CT values as early as 15 min post-reperfusion, which showed a strong correlation with the histopathological analysis results. Additionally, Bi-DTPA dimeglumine can be almost eliminated from the body via the kidneys within 24 h. As an inherently advantageous alternative to iodinated imaging probes, Bi-DTPA dimeglumine exhibits promising prospects for application in liver disease diagnosis.
研究领域:
医学成像
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肝病学
·
放射学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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