RARE METALS
·
2016
·Vol. 41
·期 12
·4273-4278
·
IF 0.957
Huang Shuang,Xu Hua-Lan,Wang Lei,Zhong Sheng-Liang
Rice-like Gd(OH) 3 nanorods were successfully prepared through a facile and rapid microwave-hydrothermal synthesis method without using any surfactants or templates. X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED) and energy-dispersive spectroscopy (EDS) were used to characterize the samples. Results show that the nanorods have an average length of 400 nm and an average diameter of 50 nm. The effects of reaction parameters such as reaction temperature and time on the preparation were briefly investigated. It is found that the crucial factor for the formation of rice-like Gd(OH) 3 nanorods is reaction time. When the rice-like Gd(OH) 3 nanorods was codoped with Yb 3+ and Er 3+ , strong upconversion emissions could be observed under the excitation of 980-nm-laser, and the calculated CIE color coordinates falls within the yellow region, which may be potential candidate for optical materials.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2012
·Vol. 36
·期 6
·1335-1338
·
IF 2.605
Sa Huang,Jianhua Liu,Di Liu,Qinghai Yuan
We report the facile and scalable synthesis of a highly monodispersed inorganic nanostructure based on well-designed Gd(OH)3 nanorods. X-Ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), as well as energy-dispersive spectroscopy (EDS) were applied to characterize the samples, indicating that the nanomaterials with an average length of 100 nm and an average diameter of 15 nm showed a typical hexagonal phase. Biocompatibility tests were performed from in vitro cell experiments to in vivo long-term histological assessment, indicating that the Gd(OH)3 nanorods were promising for further bio-related application. Owing to the excellent paramagnetic behavior, we further investigated the capability of the nanorods as MRI contrast agent. Compared with the conventional Gd–DTPA complex, the well-designed Gd(OH)3 nanorods present a higher T1 relaxation rate, showing more potential for biomedicine applications.
研究领域:
材料科学
·
医学影像
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 39
·期 11
·8999-9005
·
IF 3.086
Yingda Du,Ming Xing,Zhiman Li,Wei Guo
Along with the rapid development of modern medicine, the creation and evaluation of nanoparticulate contrast agents have attracted considerable attention of scientists worldwide. Herein, we designed and synthesized a metabolizable nano-sized contrast agent based on rod-like PEGylated gadolinium hydroxide (defined as PEG-Gd(OH)3) via a facile and economic route. Due to the high amount of gadolinium in these nanorods, these well-prepared PEG-Gd(OH)3 could provide more enhanced contrast than clinical iodine-based agents under the usual voltages in computed tomography (CT) imaging. Different from other small molecule-based contrast agents, our PEG-Gd(OH)3 exhibited an obvious liver-targeted property based on our in vivo experiments, indicating their expected usage in the detection of hepatic metastases. Long-term toxicity and possible metabolic pathway demonstrated that these nanorods exhibit overall safety and could not cause gadolinium-associated nephrogenic systemic fibrosis (NSF). With its high biocompatibility and superior contrast efficacy, PEG-Gd(OH)3 could bring more opportunities to a new generation of nanoparticulate CT contrast agents in biomedicine.
研究领域:
医学影像学
·
纳米医学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
Biosensors-Basel
·
2022
·Vol. 12
·期 12
·1141
·
IF 5.743
Chunyuan Tian,Minggang Wei,Xiaobin Wang,Qing Hua,Feiyan Tang,Lijun Zhao,Xuming Zhuang,Feng Luan
In the present study, the electrochemiluminescence (ECL) properties of Gd(OH)3nanocrystals with K2S2O8as the cathode coreactant were studied for the first time. Based on the prominent ECL behavior of this material and the excellent specificity of the aptamer technique, an ECL aptasensor for the detection of ochratoxin A (OTA) was formulated successfully. Over an OTA concentration range of 0.01 pg mL−1to 10 ng mL−1, the change in the ECL signal was highly linear with the OTA concentration, and the limit of detection (LOD) was 0.0027 pg mL−1. Finally, the ECL aptasensor was further used to detect OTA in real samples (grapes and corn) and satisfactory results were obtained, which indicated that the built method is expected to be applied in food detection.Keywords:Gd(OH)3nanocrystals;electrochemiluminescence;aptasensor;ochratoxin A;food detection
研究领域:
分析化学
·
食品科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2016
·
IF 2.435
Hai Wu,Youjin Zhang,Maozhong Zhou,Chengpeng Yao,Xianjin Ge
Large single crystals of gadolinium hydroxide [Gd(OH) 3 ] in the length of several millimeters were successfully prepared by using solid KOH assisted hydrothermal method. Gd(OH) 3 samples were characterized by X-ray diffraction (XRD), 4-circle single-crystal diffraction, Fourier transform infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS). FESEM image shows hexagonal prism morphology for the Gd(OH) 3 large crystals. The possible growth mechanism of Gd(OH) 3 large single crystals was proposed. The photoluminescence and magnetic properties of Gd(OH) 3 species were investigated.
研究领域:
材料科学
·
光学
·
磁学
✓ 已验证
DOI
高影响因子
GIANT
·
2022
·
IF 0
Yifan Jia,Weiwen Yuan,Mengmeng Xu,Congyi Yang,Lei Chen,Shuo Wang,Paul D. Topham,Guoxuan Luo,Mo Wang,Yong Zhang,Guihua Jiang,Qianqian Yu,LinGe Wang
Magnetic resonance imaging (MRI)-active polymers exhibit unique advantages for in vivo diagnosis. Here, in order to endow electrospun fibers with long-term T 1 positive MRI visibility, MRI contrast agent (CA), Gd(OH) 3 , is introduced in a new, extremely convenient method. Crucially, GdCl 3 is reacted with NaOH in situ during electrospinning, with flexibility to deliver both well-dispersed and aggregated Gd(OH) 3 clusters within a poly(ethylene terephthalate) (PET) matrix. T 1 and T 2 relaxivities of Gd(OH) 3 in PET nanofibers are studied. Well-dispersed Gd(OH) 3 (sub-nanometer in size) exhibits 34 times higher T 1 relaxivity than aggregated nanoparticles when embedded within the fibers. The morphology, structure, magnetic properties, tensile properties, imaging performance and biosafety of the PET/Gd(OH) 3 composite fibers are evaluated to identify the optimum conditions to produce new materials with balanced properties, excellent in vivo positive contrast and approximately 139 days imaging lifetime. Comparing this sample with a commercial CA, only 0.32 wt.% Gd loading is needed to attain similar MRI signal intensity. In summary, PET/Gd(OH) 3 long-term MRI-active fibers show great potential for future biomedical applications and the study also provides a promising new general strategy to enhance the MRI T 1 positive contrast of electrospun fibers of a whole host of other systems.
研究领域:
材料科学
·
医学影像学
·
生物医学工程
✓ 已验证
产品关联
DOI
危险品化学品经营许可证（带存储）