CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Ningning Li,Ying Zhou,Hao Sun,Nan Wang,Nan Yang,Peiyao Ren,Lanjun Fu,Yiming Zhang,Wei Liu,Yanjie Li,Juan Jin
Rapid and accurate glucose monitoring is extremely crucial for the health management of diabetic patients. Whereas the non-invasive detection of salivary glucose is promising alternative. In this study, a newly designed MOF/MIPs paper-based microfluidic biomimetic chip (MM-SGM-chips) was successfully constructed based on boron-affinity orientation surface imprinting strategy. The obtained chips demonstrated high adsorption capability (Q e = 213.40 mg·g −1 ), excellent selectivity (IF = 3.7), speedy detection (less than 30 min), and satisfied anti-interference ability for glucose. Moreover, the MM-SGM-chips could be capable of rapid and sensitive quantification of glucose level ranged from 0.1-3.2 mM through visual detection, with a limit of detection as low as 0.02 mM. Furthermore, the real clinical samples in daily period were collected for validating its correlation with serum glucose level. Present works demonstrated the promising potentiality of MM-SGM-chips for home self-test and even point-of-care testing clinical applications.
研究领域:
生物医学工程
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分析化学
·
糖尿病研究
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DOI
高影响因子
ANALYTICAL SCIENCES
·
2020
·Vol. 36
·期 9
·1025-1030
·
IF 2.049
Xiaoxuan LI,Lijun LI,Yuhan HE
Based on the reversible covalent binding between borates and glycoproteins, we proposed a scheme that can specifically recognize and detect immunoglobulin G (IgG). The application of magnetic materials to enrich SERS probes can provide an enhanced signal and repeatability. The results showed that the prepared sandwich-like complex displayed high sensitivity and excellent selectivity for IgG. The Raman peak intensity showed a good linear relationship in the concentration range of 1 mg/mL – 1 ng/mL. The linear equation was y = 657.93x + 2963.9, R2 = 0.996. Parallel testing of this sandwich-like complex proved to have excellent repeatability. This method provided a new possibility for clinical non-immunity and the quantitative detection of IgG.
研究领域:
分析化学
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生物医学
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2025
·
IF 5.1
Xiqing Liu,Tao Wang,Yongqing Wang
Fluorescence technology enabled highly sensitive, real-time and multi-scenario detection of lysozyme (Lys). However, fluorescent nanomaterials suffer from aggregation-induced quenching, environmental interference and lack of selective recognition capability. In this work, the ZIF-8 was used as a framework to support red and blue fluorescence quantum dots for constructing ratiometric fluorescence sensor. At the same time, combined with molecular imprinting technology, a Molecular Imprinting Polymers (MIPs)-based ratiometric fluorescence sensor was designed for improving the sensitive and selective. The MIPs-based ratiometric fluorescence sensor exhibited highly sensitively and selectively for the detection of lysozyme. Benefited from ratiometric design, the sensor could realize the effect of visual detection of Lys and the limit of detection (LOD) was reached 0.048 mg/L. The HPLC method was used to further confirm the sensor has the potential for practical application. Furthermore, to the demand of an affordable and portable strategy for visual detection Lys, a dexterous and inexpensive test paper was made in this work.
研究领域:
分析化学
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纳米技术
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荧光传感
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材料科学
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生物传感
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环境监测
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DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Can Zhang,Yongfei Zhou,Li Ming,Lihong Chen,Minqiao Xue,Jing Zhang,Hongyan Zhang
The inclusion of artificial food additives such as vanillin in infant formula should be strictly monitored to mitigate potential negative impacts on the dietary habits and health of infants. This raises a necessity of an accurate inspection and prompt feedback of vanillin in infant foods. In this study, colorimetric and fluorescent dual–mode assays based on CuNS/Fe 3 O 4 @MIPs were established to detect vanillin selectively and sensitively. Quantification of vanillin could be achieved with linear detection ranges of 1–100 μM and 1–150 μM for the colorimetric and fluorescent assays respectively. The corresponding detection limits were 0.11 and 0.10 μM respectively. The CuNS/Fe 3 O 4 @MIPs–based dual–mode assays exhibited good selectivity and stability for vanillin detection in infant formula and milk-based foods. Hence, this method can serve as a reliable tool for the cost-saving, effective and quantitative determination of vanillin in infant foods, with the potential to replace conventional instrumental analysis.
研究领域:
食品科学
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分析化学
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DOI
PubMed
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2026
·
IF 2.4
Ying Li,Xuemeng Li,Mingjie Han,Hailong Bai,Lei Ru,Jiying Men
The elevation of creatinine in the blood is a typical indicator of renal dysfunction, and persistent renal insufficiency can eventually develop into kidney failure, requiring patients to rely on dialysis or kidney transplantation to maintain their lives. This study focuses on the preparation and performance evaluation of a molecularly imprinted membrane, PVA@CS-MIPs, designed for selective adsorption of creatinine. The PVA@CS-MIPs membrane was fabricated using PVA/CScomposite base membrane prepared via solution casting, with α-methylacrylic acid (MAA) as the functional monomer, N,N′-methylenebisacrylamide (MBA) as the crosslinker, and cerium ammonium sulfate (ACS) and concentrated sulfuric acid as initiators. The PVA@CS-MIPs membrane was characterized using FT–IR, SEM, and XPS. The adsorption and permeation behaviors of PVA@CS-MIPs were investigated, and the underlying mechanisms were discussed. The results demonstrate that PVA@CS-MIPs exhibit a high adsorption capacity of 322.5 mg/g for creatinine and good adsorption selectivity. Moreover, the membrane exhibits excellent reusability. These findings suggest that the prepared PVA@CS-MIPs possesses specific recognition ability forcreatinine and hold promise for applications in hemodialysis-related fields.
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DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Run-tian Ma,Jun Zhang,Jin-xiu Guo,Fang Nian,Cheng Wang,Wei-bing Xu
Lactoferrin (Lf) is one of the important nutrients in milk, and its detection is crucial for dairy and breeding industry. However, the high cost, complex operation and dependence on advanced instruments limited its detection in small and medium-sized pastures. Thus, a detection device as a portable slide based MIPs-FL sensor was fabricated by preparing MIPs on the surface of ZnO nanoflowers functionalized slide, and it could be directly used in milk without any pre-treatments. The prepared detection device showed a high selectivity towards Lf with an imprinting factor of 9.05 and a binding affinity of 356.34 mL/g. Correspondingly, an on-line detection method for Lf was established with good linear relationship ( r > 0.9680) in the range of 0.0625 mg/mL-1.00 mg/mL, and the value of LOD and LOQ were 0.0207 mg/mL and 0.0690 mg/mL, respectively. This convenient method was successfully applied in ten milk samples, and showed application potential in on-situ detection.
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2016
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IF 4.035
Caishuang Liang,Huan Wang,Kui He,Chunyan Chen,Xiaoming Chen,Hang Gong,Changqun Cai
Major stumbling blocks in the recognition and detection of virus are the unstable biological recognition element or the complex detection means. Here a fluorescent sensor based on virus-molecular imprinted polymers (virus-MIPs) was designed for specific recognition and highly sensitive detection of Japanese encephalitis virus (JEV). The virus-MIPs were anchored on the surface of silica microspheres modified by fluorescent dye , pyrene-1-carboxaldehyde (PC). The fluorescence intensity of PC can be enhanced by the principle of fluorescence resonance energy transfer (FRET), where virus acted as energy donor and PC acted as energy acceptor. The enhanced fluorescence intensity was proportional to the concentration of virus in the range of 24–960 pM, with a limit of detection (LOD, 3σ) of 9.6 pM, and the relative standard deviation was 1.99%. In additional, the specificity study confirmed the resultant MIPs has high-selectivity for JEV. This sensor would become a new key for the detection of virus because of its high sensitive, simple operation, high stability and low cost.
研究领域:
生物化学
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分析化学
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病毒学
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DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2018
·Vol. 411
·期 2
·537-544
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IF 3.307
Ran Hui,Lin Zheng-Zhong,Yao Qiu-Hong,Hong Cheng-Yi,Huang Zhi-Yong
A facile and practical ratiometric fluorescence probe based on two CdTe quantum dots (QDs) coated with molecularly imprinted polymers (MIPs) was prepared for the detection of trace malachite green (MG) in fish. Two CdTe QDs coated with MIPs were fabricated by a one-pot method using MG, (3-aminopropyl) triethoxysilane (APTES) and tetraethyl orthosilicate (TEOS) as template, functional monomer, and cross-linker, respectively. CdTe QDs with λ em 530 nm (gQDs) and 630 nm (rQDs) were used as the referential fluorophore and target sensitive fluorophore, respectively. The fluorescence intensity of gQDs remained unchanged in the presence of MG, while the fluorescence of rQDs could be quantitatively quenched by MG based on the strategy of fluorescence resonance energy transfer. The ratiometric fluorescence probe (MIPs@gQDs&rQDs) was characterized by transmission electron microscopy and Fourier transform infrared spectroscopy. The linear range of MG detection was 0.1–32 μmol L −1 with a detection limit of 8.8 μg kg −1 . The constructed probe has been successfully applied to the detection of MG in fish with the recoveries of 92.3–109.1%, which were validated by the method of HPLC. The result indicated that the probe possessed rapid response, wide linear range, high sensitivity, and relatively high selectivity, and was low-cost and easy in operation in the detection of MG in fish samples.
研究领域:
分析化学
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环境科学
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食品安全
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DOI
PubMed
高影响因子
POLYMER INTERNATIONAL
·
2021
·Vol. 71
·期 3
·301-309
·
IF 2.99
Xusheng Huang,Qingsong Liu,Wencheng Zhang,Zeyu Wu,Yunchun Wang,Jianwen Li,Baoyi Xiong,Zhaojun Xian
The preparation of raw materials is an important prerequisite for studying the function of natural active ingredients. Here, the preparation of MWCNTs/ZIF-67@MIPs based on surface molecular imprinting technology for the separation of bilobalide (BB) from real samples was proposed. The successful preparation of MWCNTs/ZIF-67@MIPs was demonstrated using several techniques. Adsorption equilibrium was achieved when the time was 4 h, and the rate of adsorption calculated from the dynamic adsorption results was 14.2 μg mL –1 h –1 . The maximum adsorption amount for MWCNTs/ZIF-67@MIPs of BB was calculated to be 59.2 mg g –1 , which was more than three times that for MWCNTs/ZIF-67@NIPs (23.1 mg g –1 ), and the Freundlich isotherm model and pseudo-second-order kinetic model were more suitable for the explanation of isothermal and kinetic adsorption behaviors, respectively. The results of selective adsorption indicated that MWCNTs/ZIF-67@MIPs show excellent selectivity and specificity for BB compared to structurally similar compounds such as ginkgolides A, B and C, with an excellent imprinting factor (2.83). The results of reuse studies indicated that MWCNTs/ZIF-67@MIPs exhibited great reproducibility with a recovery rate of 70.8% after repeated use for five times. Finally, the developed MWCNTs/ZIF-67@MIPs were used as a solid-phase extraction sorbent to directly separate BB from treated gingko leaf extract and crude extract of BB, and the results suggested that the purity of BB in the two samples was increased by about 30%, and the recoveries reached 68.34% and 71.54%, respectively. Meanwhile, the separation effect of MWCNTs/ZIF-67@MIPs on BB was better than that of BBMIP prepared by bulk polymerization. © 2021 Society of Industrial Chemistry.
研究领域:
分析化学
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天然产物化学
·
材料科学
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DOI
高影响因子
KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2026
·
IF 3.4
Chen Jianjun,Wu Haowen,Ru Lei,Bai Hailong,Han Mingjie,Feng Hua,Men Jiying
In this work, surface molecularly imprinted polymers Co-MOF/CNT@MIPs were prepared based on metal-organic framework (MOF) and muti-walled carbon nanotubes (MWCNTs) as matrix, and norfloxacin (NOR) as template molecular. The structural characteristics of molecular imprinted polymer Co-MOF/CNT@MIP were confirmed by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS). The adsorption and selective recognition performances of Co-MOF/CNT@MIP for NOR were also investigated. The adsorption of Co-MOF/CNT@MIP for NOR reaches equilibrium at 300 min, and pseudo-second-order (PSO) model is more fit for adsorption kinetic. The adsorption capacity of Co-MOF/CNT@MIP for NOR reaches 78.6 mg/g with 1.5 mg/mL at 25℃ via the hydrogen bond interaction and “lock-key” imprinted cavities, and the D-R model is fit for adsorption isotherm. The adsorption amount decreases as increasing the temperature, which is an exothermic and spontaneous process. The imprinted polymer exhibits an excellent imprinted factor of 2.08 and high selective factor above 1.93, and it is satisfactory reusability for five cycles.
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DOI
高影响因子
Biosensors-Basel
·
2023
·Vol. 13
·期 3
·330
·
IF 5.4
Jing Neng,Yazhi Wang,Yilong Zhang,Peng Chen,Kai Yang
The quinolone antibiotics represented by enrofloxacin (ENRO) are harmful to the ecological environment and human health due to illegal excessive use, resulting in increasing food residues and ENRO levels in the environment. To this end, we developed a MIPs–SERS method using surface-enhanced Raman spectroscopy (SERS) and molecularly imprinted polymers (MIPs) to detect ENRO in food matrices. Firstly, a layer of silver nanoparticles (Ag NPs) with the best SERS effect was synthesized on the surface of copper rods as the enhancing material by in situ reductions, and then MIPs targeting ENRO were prepared by the native polymerization reaction, and the MIPs containing template molecules wrapped on the surface of silver nanoparticle films (Ag NPs–MIPs) were obtained. Our results showed that the Ag NPs–MIPs could specifically identify ENRO from the complex environment. The minimum detection limit for ENRO was 0.25 ng/mL, and the characteristic peak intensity of ENRO was linearly correlated to the concentration with a linear range of 0.001~0.1 μg/mL. The experimental results showed that in comparison to other detection methods, the rapid detection of ENRO in food matrices using Ag NPs–MIPs as the substrate is reliable and offers a cost-effective, time-saving, highly selective, and sensitive method for detecting ENRO residues in real food samples.Keywords:surface-enhanced Raman spectroscopy;molecularly imprinted polymers;biosensor;enrofloxacin
研究领域:
食品安全检测
·
环境科学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2018
·Vol. 410
·期 24
·6237-6245
·
IF 3.307
Zhang Yida,Cao Huawei,Huang Qiangwei,Liu Xiaoyan,Zhang Haixia
Transferrin (TrF) is a very important human body glycoprotein and a clinical biomarker which controls the body’s iron ion channels and iron ion balance. Any change in TrF concentration and isoform also reflects the emergence of some diseases. In this work, we prepared magnetic molecularly imprinted nanoparticles (deep eutectic solvent-molecular imprinting polymers [DES-MIPs]) with a deep eutectic solvent (DES) as a functional monomer to separate TrF in human serum. The DES dosage for MIP, pH value, and time for adsorption have been optimized, and these materials show special adsorption properties for TrF. The maximum adsorption capacity ( Q max ) and dissociation constant K L of the MIP by the Langmuir adsorption curve ( R 2 = 0.9949) were 37.5 mg/g and 0.015 g/L, respectively. The imprinting factor of the MIP is 3.50 with relative standard deviation (5.63%). In summary, the use of DES as a functional monomer in molecular imprinting technology provides a novel, efficient, and biocompatible method for the isolation and purification of proteins.
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研究领域:
生物技术
·
分析化学
·
材料科学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）