ACS Chemical Neuroscience
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2022
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IF 5.78
Guolong Huang,Yifan Qiu,Lei Bi,Huiyi Wei,Guocong Li,Zhijun Li,Peizhen Ye,Min Yang,Yanfang Shen,Hao Liu,Lu Wang,Hongjun Jin
The P2X7 receptor (P2X7R) is a key neuroinflammation target in a variety of neurodegenerative diseases. Improved radiosynthesis was developed according to the previously reported P2X7R antagonist GSK1482160. Biodistribution, radiometabolite, and dynamic positron emission tomography/computed tomography-magnetic resonance imaging (PET/CT-MRI) of the lipopolysaccharide (LPS) rat model and the transgenic mouse model of Alzheimer’s disease (AD) revealed a stable, low uptake of [18F]4A in the brain of healthy rats but a higher standardized uptake value ratio (SUVR) in LPS-treated rats (1.316 ± 0.062, n = 3) than in sham (1.093 ± 0.029, n = 3). There were higher area under curves (AUCs) in the neocortex (25.12 ± 1.11 vs 18.94 ± 1.47), hippocampus (22.50 ± 3.41 vs 15.90 ± 1.59), and basal ganglia (22.26 ± 0.81 vs 15.32 ± 1.76) of AD mice (n = 3) than the controls (n = 3) (p < 0.05). Furthermore, 50 min dynamic PET in healthy nonhuman primates (NHPs) indicated [18F]4A could penetrate the blood–brain barrier (BBB). In conclusion, [18F]4A from this study is a potent P2X7R PET tracer that warrants further neuroinflammation quantification in human studies.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Tongtong Pan,Xiangmei Cui
A composite aerogel with good mechanical properties and adjustable physical properties was synthesized by a sol-gel technique on the base of gelatin for the boron adsorption from water solution. The adsorption key variables, for instance, initial boron concentration (C 0 ) (900–1100 mg/L), the contact time (t) (8–9 h), and pH (9–11), were optimized using central composite design to obtain improved boron adsorption performance of epichlorohydrin-modified gelatin (EMG)/ N -methyl- d -glutamine (NMDG) aerogel loaded with hydroxylated carbon nanotubes (EMG@NMDG). The adsorption followed the pseudo-second-order and Freundlich model. At pH of 10, C 0 of 1000 mg/L and t of 10 h, the largest adsorbed amount of EMG@NMDG was 85.79 mg/g. Regeneration experiments were carried out by eluting the adsorbent using HCl. The analysis showed that the adsorption in actual brine was 62.65 mg/g. Therefore, the developed EMG@NMDG aerogel has potential value for the boron extraction from brine and wastewater.
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JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
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2023
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IF 2.3
Kong Ruiping,Xu Lingwei,Zhu Li,Sun Yongrong
In an endeavor to ameliorate the solubility and subsequent oral bioavailability of Cefixime (CEF), a drug noted for its deficient water solubility, the formulation of ternary inclusion complexes was executed utilizing hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutylether-β-cyclodextrin (SBE-β-CD), in conjunction with N-methyl-D-glucaminet (MG). This development was realized through the application of a mechanochemistry technique, acknowledged for its “green” credentials. The complexes' physicochemical attributes were meticulously examined through various analytical techniques: Fourier-transform infrared spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Powder X-ray Diffractometry (XRD), and Scanning Electron Microscopy (SEM). Notably, the ternary complexes exhibited an uplift in apparent drug solubility, especially when juxtaposed with binary complexes. A prominent augmentation was perceived in the stability constant (Kc) and complexation efficiency (CE) when MG was integrated into the ternary complexes with HP-β-CD or SBE-β-CD. Further exploratory molecular docking and molecular dynamics studies underscored MG’s role in augmenting complex stability by serving as a bridge between CEF and cyclodextrins (CDs). The parallel artificial membrane permeability assay (PAMPA) indicated a conspicuous enhancement of CEF permeability in the ternary complexes relative to the control–free CEF. The particle size and zeta potential of the mechanochemically processed ternary complexes in liquid form were assessed using Dynamic Light Scattering (DLS). Moreover, in vivo evaluations revealed the ternary complexes to manifest notably superior oral bioavailability when compared to unadulterated CEF. Lastly, through the rapid storage assay, a heightened physicochemical stability was observed in the mechanochemically synthesized CEF ternary supramolecular inclusion complexes, compared to the pure drug, intimating a pioneering approach for the oral delivery of CEF, ensuring improved bioavailability. Graphical abstract
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CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Wenqing Wang,Hao Li,Yongquan Zhou,Jianming Pan
The emulsion method is a typical way for the preparation of nanomaterials, however, it usually requires a lot of energy and surfactants to form and stabilize of emulsions. A critical factor limiting its application is to control the morphology of the material by modulating the size of the emulsion droplets. In this work, a novel solid-water–oil (S-W-O) system based on the integration of metastable emulsion and salt template method was proposed, and the functionalized silica nanosheets were prepared by the one-pot method. The size of the prepared nanosheets is relatively uniform, with a length of 800 to 1200 nm and a width of about 200 nm. Subsequently, a large number of epoxy group sites were introduced into the nanosheets relying on distillation precipitation polymerization, and the polyol groups were successfully loaded. Finally, the polyol-functionalized nanosheet adsorbent (NS@GMA-NMDG) was obtained and applied for the rapid removal of boron. NS@GMA-NMDG shows favorable adsorption performance for boric acid in solution, with a maximum adsorption capacity of about 35.49 mg g −1 based on the Langmuir model fitting and a fast adsorption rate of about 30 min to reach 96.3% of the adsorption equilibrium concentration. Remarkably, the investigation of the formation mechanism of nanosheets reveals that salt plays an important role in the S-W-O system. This study not only puts forward a novel method of designing and synthesizing nanosheet adsorbents, but also the application of surfactant-free and low-energy emulsification reflects the concepts of energy saving and clean production, which provides fresh inspirations for the development of new environmentally friendly adsorbents.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2021
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IF 4.539
Chun Bai,Kexin Li,Dezhen Fang,Xiushen Ye,Huifang Zhang,Quan Li,Jun Li,Haining Liu,Zhijian Wu
A novel flotation agent named N-octadecyl-N-methyl- D -glucamine (NO-NMDG), was designed and prepared using N-methyl- D -glucamine as a polyhydroxy molecule and 1-bromooctadecane as the provider of a long-chain alkyl group . The results of characterization by NMR, MS and FT-IR showed that the target compound was successfully synthesized. NO-NMDG can effectively separate boron from aqueous solutions because of its complexing ability for boron and its foamability. The flotation experiments results showed that the flotation isotherm was in better accordance with the Langmuir model, indicating that the surface reaction in flotation by NO-NMDG belongs to the single molecular layer trapping. The response surface experimental results indicated that under the optimum conditions, the boron recovery rate can reach to 89.12%. The boron recovery rate in Xiao Chaidan brine could reach to 97.26% by NO-NMDG. The mechanism analysis exhibited that the meglumine group in NO-NMDG can complex with boron, and the long-chain alkyl group can attach to the surface of the bubble and enter into the bubble layer to separate boron from the aqueous solution.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2020
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IF 2.734
Qihong Zhang,Wei Ren,Alexandr V. Dushkin,Weike Su
Olmesartan medoxomil (OM) has been used in treatment of hypertension disease, as a prodrug of olmesartan. However, its clinical application is limited by the low oral bioavailability (~28%). Ternary solid dispersion of OM was prepared with hydroxypropyl- β -cyclodextrin and N -methyl- d -glucamine to improve its oral bioavailability using roll mill ML 007. Its physicochemical characterization was measured by scanning electron microscope, differential scanning calorimetry , powder X-ray diffraction and transform infrared spectroscopy . The solutions properties of OM in ternary solid dispersion were investigated involving the solubility, dissolution profiles, 1 H NMR analysis, phase solubility study and PAMPA study. Instrument analysis results revealed an amorphous solid dispersion had been synthesized without any side-products. It also showed enhanced solubility and dissolution rate in vitro . Pharmacokinetic study demonstrated an improved oral bioavailability in vivo . The rapid storage assay showed that the chemical stability of inclusion complexes had no change. The synthesized OM ternary solid dispersion is promising to be a better alternative to its pure formation in the market with improved oral bioavailability.
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JOURNAL OF HAZARDOUS MATERIALS
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2021
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IF 10.588
Mei Hong,Die Li,Bingyu Wang,Jingyu Zhang,Bin Peng,Xiaoling Xu,Yan Wang,Chunyang Bao,Jing Chen,Qiang Zhang
Excess boron in water could result in a critical hazard to plants and humans. Traditional treatment approaches cannot efficiently remove boron from water, especially during seawater desalination using reverse osmosis technology . Achieving satisfactory adsorption capacity and rate for boron remains an unmet goal for decades. Herein, we report cellulose-derived polyols as high-performance adsorbents that can rapidly remove boron and organic pollutants from water. Cellulose-derived polyols were synthesized from saccharides and cellulose via controlled radical polymerization and click reaction. Remarkably, CA@NMDG can adsorb boron with an astonishing capacity of ~34 mg g -1 in 10 min, which surpasses all those cellulose-based materials reported thus far, meanwhile, much faster than those of commercial adsorption resin. Moreover, cellulose-derived polyols also showed high removal efficiencies (70–98% in several minutes) toward certain organic pollutants, including Congo red and Reactive Blue 19. The water-insoluble characteristic of cellulose-derived polyols is advantageous to be separated from the treated sewage after adsorption for reuse. This work provides a novel insight into the fabrication of safe, fast, and high-capacity cellulose adsorbents for water purification .
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ChemSusChem
·
2019
·Vol. 12
·期 22
·5041-5050
·
IF 7.804
Ming Zhao,Tianhao Li,Lichao Jia,Huilin Li,Weiyong Yuan,Chang Ming Li
Graphical Hydrothermal self-assembly : Graphene-supported carbon with an ultrahigh N-doping level is controllably synthesized by facile and economical in situ self-assembly of a glucaminium-based ionic liquid on pristine graphene under hydrothermal conditions. As an electrocatalyst, it exhibits superior catalytic activity and durability in the oxygen evolution reaction. For the first time, graphene-supported N-doped carbon (G@NC) with a high degree of N doping was synthesized by in situ self-assembly of a glucaminium-based ionic liquid on pristine graphene under hydrothermal conditions. This 2D, metal-free nanohybrid exhibited much higher catalytic activity than most reported metal-free catalysts for the oxygen evolution reaction (OER) and even state-of-the-art Ir- and Ru-based catalysts because the high content of graphitic N greatly increased the number of OER-active sites, the pristine graphene significantly promoted the OER activity of the C sites adjacent to the graphitic N atoms, and N-doped graphitic carbon remarkably enhanced the charge-transfer rate. This work not only creates a facile and economical approach to controllably fabricate pristine-graphene-supported carbon with a high N-doping level for the development of highly efficient metal-free OER catalysts but also provides insight into the mechanisms for both the in situ self-assembly and the high OER catalytic activity of G@NC.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2020
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IF 5.278
Yanyun Bai,Jinxing Li,Xiumei Tai,Guoyong Wang
A series of meglumine-based polysiloxane surfactants, (PSi m-n ) with different numbers of meglumine branches were prepared. The formed surfactants were characterized by FT-IR and NMR techniques. Physiochemical properties, such as surface activity, aggregation behavior, and wettability, were closely examined and used to differentiate the various samples. The findings demonstrate that PSi m-n surfactants possess high surface activity and can wet-out a parafilm surface at all but extremely low concentrations. Furthermore, PSi 6-4, the surfactant with the highest meglumine concentration, can form larger complex aggregates in aqueous solutions.
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ACS Sustainable Chemistry & Engineering
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2019
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IF 6.97
Jinxing Li,Yanyun Bai,Wanxu Wang,Xiumei Tai,Guoyong Wang
A novel green glucamine-based trisiloxane surfactant (HAG) composed of a glucamine headgroup and trisiloxane tail was prepared by a completely “green” synthesis. Its chemical constitution, functional groups, and surroundings were characterized by Fourier transform infrared spectroscopy, mass spectrometry, and 1H and 13C NMR spectroscopy. The physicochemical properties of the target, including its surface activity, aggregation, and wetting behavior, were evaluated systematically. The findings reveal that HAG solution has a comparatively low surface tension (γ = 19.04 mN/m) and can spread rapidly on a parafilm surface. Furthermore, it can spontaneously assemble into vesicles.
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Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 25
·15137-15144
·
IF 10.733
Lei Hu,Li Gao,Xiaoming Yan,Wenji Zheng,Yan Dai,Ce Hao,Xuemei Wu,Gaohong He
An advanced ion-selective membrane containing a dynamic hydroxyl-based 3D H-bond network is first proposed for improved efficiencies and stability in flow battery applications. The 3D H-bond network structure is constructed by the nanoscale aggregation of hydrophilic dense-hydroxyl side chains anchored to hydrophobic polybenzimidazole. This unique dynamic H-bond network creates proton transport highways as well as vanadium permeation barriers across the membrane, leading to an ultralow vanadium ion permeability (<10−9 cm2 s−1) and remarkably low area resistance (0.32 Ω cm−2). This membrane exhibits high coulombic efficiencies (CE: 98.0–99.2%) and energy efficiencies (EE: 88.9–77.9%) at high current densities (80–200 mA cm−2), together with a long lifetime of over 800 cycles (about 42 days) at 120 mA cm−2 in vanadium flow batteries. The design of dynamic 3D H-bond networks provides a promising strategy for the development of highly ion-selective and stable membranes for flow battery application.
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ACS Applied Materials & Interfaces
·
2018
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IF 8.097
Xueri Nan,Jing Liu,Xiuli Wang,Xianhui Pan,Xiaomei Wang,Xu Zhang
Three-dimensionally ordered macroporous cross-linked poly(glycidyl methacrylate) (3DOM) was constructed by water-soluble colloidal crystal templates and further functionalized with N-methyl-d-glucamine (NMDG) to prepare superhydrophilic adsorbents for boron removal from natural seawater. 3DOM adsorbents possess features of interconnected macropore structure, ultrathin pore wall, and superhydrophilicity, making efficient adsorption possible. The effect of cross-linking degree on the adsorption capacity toward boron was investigated. The NMDG-modified 3DOM adsorbent with rich vicinal diol functional groups showed superhydrophilicity and outstanding performance of adsorption. Significantly, its adsorption effect in boron removal from natural seawater indicated that the concentration of boron in natural seawater could decline to 0.16 from 4.24 mg·L–1 when the adsorbent dosage was 1 g·L–1, whereas the boron rejection reached 96.2%. After 10 regeneration–adsorption cycles, the adsorption capacity of 3DOM adsorbent remained over 85% of the initial value and the ordered structure was hardly changed. Additionally, 3DOM adsorbent could be directly and quickly separated from the seawater by a filter mesh of 16 mesh number. Research shows that the 3DOM adsorbent exhibits an adsorption performance for practical applications in boron removal from natural seawater.
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