Science China-Chemistry
·
2026
·
IF 9.8
Dai Huan,Yang Mingyu,Yang Hongkun,Liu Haiquan,Ke Zunjian,He Dong,Xiao Xiangheng
Electrochemical nitrate reduction (NO 3 RR) represents an environmentally sound pathway for converting nitrate ions (NO
− 3
) to ammonia in wastewater. However, the mechanism governing NO
− 3
hydrogenation under altered liquid-phase conditions remains poorly understood. This study enhances the reactivity of CeO 2 toward nitrate hydrogenation by loading it with transition metals and further modifying the composition of alkali metal cations in the electrolyte. This approach regulates the continuity of both interfacial water and hydrogen-bond networks, facilitating NO
− 3
-proton coupling and thereby boosting NO 3 RR reactivity. Furthermore, the incorporation of diverse surfactants into the electrolyte confirms that alterations in the liquid-phase environment influence interfacial water distribution, ultimately improving NO 3 RR reactivity. This study deepens our understanding of interfacial water’s role in NO 3 RR, providing a theoretical basis for developing more efficient electrocatalysts.
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DOI
高影响因子
STARCH-STARKE
·
2021
·
IF 2.741
Meidong Li,ZiMu Zhang,Ying Luo,Xiufang Huang,Kai Luo
Four new water-soluble polysaccharides has previously been isolated from Cardamine hupingshanensis . In this experiment, the structure of C. hupingshanensis polysaccharide NO. 3 (CHP-3) is analyzed and its in vitro anti-tumor activity is assessed. Through structural analysis, CHP-3 is found to have a molecular weight of 80.64 kDa, and be mainly composed of glucose, galactose, and L -arabinose; The backbone of CHP-3 is mainly composed of →5)-α-L-Araf-(1→ and →4)-α-D-Glc(p)-(1→), respectively. By studying its anti-tumor activity in vitro, it can be concluded that treatment with different concentrations of CHP-3 exerted diverse effects on A549 cells, with an obvious dose-dependent relationship. Moreover, after treatment with 12.8 mg mL −1 CHP-3, significant inhibitory effects are observed on the proliferation, migration, and invasion of A549 cells, indicating that it can be used as an anti-tumor agent for continued in-depth research.
研究领域:
药理学
·
肿瘤学
·
分子生物学
·
化学
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DOI
高影响因子
BIORESOURCE TECHNOLOGY
·
2020
·
IF 7.539
Zizhang Guo,Yan Kang,Zhen Hu,Shuang Liang,Huijun Xie,Huu Hao Ngo,Jian Zhang
The limited adsorption capacity of the substrate and the concentration of dissolved oxygen in constructed wetlands (CWs) have inhibited their ability to efficiently remove polycyclic aromatic hydrocarbons (PAHs) from wastewater. Presently, biochar and activated carbon modified with Fe 3+ and Mn 4+ were used as effective sorbents in the removal of benzofluoranthene (BbFA), a typical PAH, in CW microcosms. The addition of metallic ions embedded carbon increased NO 3 -N accumulation by the reduction of Fe 3+ and Mn 4+ , which led to improved BbFA degradation. Additionally, plant adsorption in root and stem sections were observed separately. The abundance of PAH-degrading microbes in the rhizosphere substrate was higher with the metallic ions embedded carbon than control group. The Fe 3+ , Mn 4+ and NO 3 -N served as electron acceptors increased BbFA microbial degradation. The removal pathways of BbFA in the modified CWs were proposed which involved settlement in the substrate, plant absorption, and microbial degradation.
研究领域:
环境工程
·
水处理
·
生物修复
·
环境微生物学
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DOI
PubMed
高影响因子
CEREAL CHEMISTRY
·
2024
·Vol. 101
·期 5
·1106-1117
·
IF 2.2
Yi Zhou,Xin Wu,Jinxin Shen,Daijun Yang,Qun Lu,Changjiang Long,Rui Liu
Background Black rice is rich in various nutrients, such as anthocyanins, which may undergo some changes during cooking. However, previous studies have been mainly focused on a single substance and paid less attention to the changes in overall nutrient components. Here, we performed widely targeted metabolomics analysis on the chemical compositional changes in a new black rice variety (‘Huamoxiang No.3’) under three cooking modes, including bottom heating (BH), induction heating (IH), and IH + pressure. Results Among the detected 1458 metabolites, 276 and 108 metabolites were differential metabolites after cooking and in three cooking modes, respectively. Cooking increased the contents of most peptides, phenolic acids, and organic acid compounds but significantly decreased those of lipids and flavonoids, particularly anthocyanins. However, phenolic acids such as chlorogenic acid, erucic acid, and p -coumaric acid increased significantly, possibly due to the release of bound phenols and degradation of flavonoids to phenolic acids, such as thermal degradation of C3G to protocatechuic acid and among the three heating modes, the IH + pressure mode resulted in the most significant changes. Conclusion Although cooking reduced the content of flavonoids and anthocyanins, the increase in phenolic acids and other substances contributed to the healthy effect of cooked black rice, and the content of these active substances increased more significantly in the IH + pressure mode.
研究领域:
食品科学
·
营养学
·
代谢组学
·
农业化学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Li Liang,Xiaoqin Li,Zhang Lin,Chen Tian,Yiqing Guo
In this study, the microstructure of sulfidated nanoscale zero-valent iron (S-nZVI), and the reaction mechanism with cadmium (Cd) were investigated. Combining with spherical aberration-corrected scanning transmission electron microscope (Cs-STEM), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and Fourier transformed infrared (FTIR), it was found that the one-step synthesized S-nZVI with Na 2 S as the sulfidation reagent is irregular in shape and consisted of heterogeneous mixtures of Fe 0 , amorphous FeS, and Fe 3 O 4 . The dominant reaction mechanism between S-nZVI and Cd is displacement of Fe in FeS and the formation of CdS. The effects of Cd initial concentration, Mg 2+ , NO 3 − , and humic acid (HA) on the reaction kinetics were also studied. The removal capacity of Cd by S-nZVI can reach up to 495 mg/g, which is significantly higher than other S-nZVI and adsorbents. The reactions follow pseudo-second-order adsorption model, with chemisorption as the rate limiting step during the displacement reaction. Low concentration of Mg 2+ (<30 mg/L), NO 3 − (<60 mg/L), and HA (<10 mg/L) slightly decreases the removal of Cd due to the competition. Moreover, S-nZVI shows high efficiency and stability towards the removal of both free Cd ions and EDTA-chelated Cd during the concentration investigated. Overall, the study shows that sulfur plays a critical role in the particle microstructure and transformation of Cd in the environment.
研究领域:
环境科学
·
材料科学
·
化学
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产品关联
DOI
高影响因子
3 Biotech
·
2026
·Vol. 16
·期 8
·328
·
IF 3.1
Zhu Hengzhou,Zhu Xiaodan,Huang Xiaona,Qian Yiyang,Li Jiahui,Zhang Jiaying,Niu Dong,Jin Chunhui
Gastric cancer (GC) is a prevalent malignancy worldwide with high morbidity and mortality. Its insidious onset and lack of sensitive early biomarkers impede routine screening, so most patients present advanced or metastatic disease at first diagnosis, leading to poor prognosis and scarce curative options. Surgery, chemotherapy and targeted therapy serve as standard GC treatments, however their efficacy is restricted by metastasis, adverse reactions and drug resistance, which drives the rapid development of immune checkpoint inhibitor (ICI)-based immunotherapy. Although monoclonal antibodies targeting programmed cell death protein 1/programmed cell death 1 ligand 1 (PD-1/PD-L1) resulted in significant survival benefits for GC patients, some patients exhibited an ineffective response. Our previous study has shown that Weitiao No. 3 (WD-3) enhanced the efficacy of anti-PD-1 immunotherapy by regulating intestinal flora in gastric cancer (GC) mice, in this study, huPBMC-NOG-dKO mice and MGC803 cells were used for in vivo and in vitro functional validation to explore the regulatory mechanism of WD-3 in GC immunotherapy. 16 S rRNA sequencing analysis of mouse fecal samples demonstrated that WD-3 significantly enriched the intestinal abundance of Lachnospiraceae and Ruminococcaceae in GC model mice. Targeted serum metabolomics further verified that WD-3 markedly elevated serum isobutyric acid level in GC mice. Combined with HE staining and tumor growth monitoring, both the intestinal flora mixture consisting of Lachnospiraceae and Ruminococcaceae and isobutyric acid prominently enhanced the anti-tumor efficacy of PD-L1 inhibitors in GC mice. Mechanistically, RNA sequencing and qRT-PCR assays identified ACOX2 as the most significantly up-regulated gene in isobutyric acid-treated MGC803 cells. Functional experiments using CCK-8 assay and flow cytometry revealed that isobutyric acid inhibited the viability and induced apoptosis of MGC803 cells, and such phenotypic changes were effectively rescued by ACOX2 knockdown. Furthermore, results from the CytoTox 96 cytotoxicity assay and ELISA revealed that combined treatment with isobutyric acid and PD-L1 inhibitor elevated the levels of LDH, IL-2, TNF-α, IFN-γ, Perforin 1 and GzmB, while suppressing IL-8, PD-1 and TIM-3 expression in CD8⁺ T cells co-cultured with MGC803 cells. Notably, all these regulatory effects were abrogated when MGC803 cells were transfected with si-ACOX2. These results suggested that WD-3 modulated intestinal flora to elevate isobutyric acid level, thereby enhancing the inhibitory effect of PD-L1 inhibitor on tumor growth and boosting the anti-tumor activity of CD8⁺ T cells by up-regulating ACOX2 expression in GC. These findings may provide novel targets for improving anti-PD-L1 therapy against GC.
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产品关联
DOI
PubMed
高影响因子
Sustainability
·
2021
·Vol. 13
·期 1
·434
·
IF 3.251
Kunlun Wang,Qian Hu,Yumin Wei,Hui Yin,Changhong Sun,Guizhong Liu
The emergent plants may differ in their capacity to assimilate nutrients from eutrophic water bodies, so the utilization of suitable emergent plants is the key part for successful restoration of shallow eutrophic lakes and rivers. This research applied the depletion method to study the kinetics of uptake of nutrient (H2PO4−,NH4+,NO3−) in different nutrient stresses by the five emergent aquatic plants (Acorus calamusL.,Typha orientalis, Lythrum salicariaL.,Sagittaria trifoliaL.,Alisma plantago-aquaticaLinn) in the riverine zones of Dashi River (39°30′–39°40′ N, 115°59′–116°5′ E), a shallow eutrophic river located in Fangshan District, Beijing. The results showed that at the three phosphorus levels,A. calamusandA. plantago-aquaticahad the highest maximum uptake rate values forNH4+under low to moderate phosphorus conditions, and high phosphorus, respectively.T. orientalishad the highest maximum uptake rate values forNO3−at all phosphorus concentrations, while the Michaelis-Menten constant values ofL. salicariaandA. plantago-aquaticawere smaller. At the three nitrogen levels, the maximum uptake rate values forH2PO4−were the greatest forA. plantago-aquaticaat the low to moderate nitrogen levels andL. salicariaat high levels. Meanwhile,T. orientalisandL. salicariahad the smallest Michaelis-Menten constant values. In this study, nitrogen microbial transformations, such as nitrification, denitrification and their coupling were not measured and their role in measuring kinetics was not assessed. Thus, achieved results shall be considered as a synthesis of several processes mediated by plants, a theoretical guidance to the selection of plant species for phytoremediation of polluted water bodies with different nutrient stresses for quality improvement around the diverse rivers in Haihe River basin.Keywords:emergent plants;eutrophication;nitrogen;phosphorus;uptake kinetics;stress
研究领域:
生态学
·
环境科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）