Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 37
·7449-7456
·
IF 4.726
Xiang Li,Qiuhong Zhang,Zeeshan Ahmad,Jie Huang,Zhaohui Ren,Wenjian Weng,Gaorong Han,Chuanbin Mao
750–850 nm (NIR I) and 1000–1400 nm (NIR II) in the near infrared (NIR) spectra are two windows of optical transparency for biological tissues with the latter capable of penetrating tissue deeper. Monitoring drug release from the drug carrier is still a daunting challenge in the field of nanomedicine. To overcome such a challenge, we propose to use porous Nd3+-doped CaTiO3 nanofibers, which can be excited by NIR I to emit NIR II light, to carry drugs to test the concept of monitoring drug release from the nanofibers by detecting the NIR II emission intensity. Towards this end, we first used electrospinning to prepare porous Nd3+-doped CaTiO3 nanofibers by adding micelle-forming surfactant Pluronic F127, followed by annealing to remove the organic component. After a model drug, ibuprofen, was loaded into the porous nanofibers, the drug release from the nanofibers into the phosphate buffered saline (PBS) solution was monitored by detecting the NIR II emission from the nanofibers. We found that the release of the drug molecules from the nanofibers into the PBS solution triggers the quenching of NIR II emission by the hydroxyl groups in the surrounding media. Consequently, more drug release corresponded to more reduction in the intensity of the NIR II emission, allowing us to monitor the drug release by simply detecting the intensity of NIR II from the nanofibers. In addition, we demonstrated that tuning the amount of micelle-forming surfactant Pluronic F127 enabled us to tune the porosity of the nanofibers and thus the drug release kinetics. This study suggests that Nd3+ doped CaTiO3 nanostructures can serve as a promising drug delivery platform with the potential to monitor drug release kinetics by detecting the tissue-penetrating NIR emission.
研究领域:
纳米医学
·
生物材料
·
光学成像
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Zhiwei Zhou,Bingchu Mei,Jinghong Song,Weiwei Li,Yu Yang,Guoqiang Yi
CaF 2 -SrF 2 hosts with substitution disorder of Ca 2+ /Sr 2+ sites in the lattice provide lower local symmetry for RE 3+ ions compared with pure CaF 2 or SrF 2 hosts, thereby facilitating more efficient 4f → 4f transitions. Here we report a study of effects of Sr 2+ content on microstructure and spectroscopic properties of Nd 3+ doped Ca 1-x Sr x F 2 transparent ceramic. Phase and microstructure analyses show that when x is in the range of 0–0.25, Nd: Ca 1-x Sr x F 2 nanoparticles keep pure CaF 2 phase with their size, morphology and agglomeration degree mildly changed. Increasing x from 0 to 0.2 significantly improves the luminescence intensity, emission lifetime and emission cross-section of Nd: Ca 1-x Sr x F 2 , however, hardly affects the concentration quenching. The luminescence intensities and emission lifetimes of x = 0.2 and 0.25 samples are very close, probably indicating SrF 2 phase has already formed in x = 0.25 sample. Based on the spectroscopic properties, the optimal Sr 2+ content is found to be x = 0.2.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Zhiwei Zhou,Yongqiang Zhang,Xinwen Liu,Bingchu Mei,Liping Zhou,Jianchun Qin,Dan Yuan
0.5–5 % (atom percent) Nd 3+ -doped SrF 2 transparent ceramics were fabricated by hot-pressed sintering and the effects of Nd 3+ doping content on microstructure and spectral properties were studied. With Nd 3+ content increased from 0.5 % to 5 %, in-line transmittance of Nd:SrF 2 ceramic at 1060 nm increased from 15.8 % to 85.3 %. FE-SEM micrographs showed the grain growth was inhibited and the microstructure became more compact and homogenous. Emission spectra revealed that concentration quenching was occurred at Nd 3+ content of 1–2 %. Emission lifetime of 4 F 3/2 energy level monotonously decreased from 1805.4 μs to 19.6 μs. Evolution profiles of emission intensity and lifetime of Nd:SrF 2 transparent ceramic with Nd 3+ doping content were proposed. The appropriate Nd 3+ content for spectral properties of Nd:SrF 2 transparent ceramic was found around 1 %. The results demonstrated Nd:SrF 2 transparent ceramic has large emission lifetime and mild concentration quenching effect, indicating that Nd 3+ -doped SrF 2 transparent ceramics could be more promising gain media for all-solid-state lasers than other Nd 3+ -doped alkaline-earth fluorides.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Xiuna Tian,Youfeng Wen,Hongjian Dou,Lingyuan Wu,Changjun Wang,Youzi Zhang
In the clinical diagnosis and treatment of diseases, there is an urgent need to find suitable materials for real-time temperature monitoring of biological tissues. The paper provides a detailed study of the effects of Nd 3+ doping concentration on the negative thermal expansion performance and NIR fluorescence properties of Sc 2 (MoO 4 ) 3 . The results obtained from Rietveld refinement of in-situ XRD data indicates that high concentration of Nd 3+ doping significantly influences the negative thermal expansion performance of the material, as well as alters the temperature-dependent changes in NIR fluorescence intensity and lifetime. In addition, a NIR fluorescence lifetime temperature probe doped with Nd 3+ /Yb 3+ /Er 3+ has been constructed. When the temperature increased from 303 K to 403 K, the fluorescence intensity of the probe at 1538 nm increased by a factor of 127.5. Furthermore, as the temperature rose from 323 K to 403 K, the fluorescence lifetime of the probe at 1538 nm extended from 41.93 μs to 204 μs. By utilizing the lifetime of Er 3+ for temperature sensing, a relative sensitivity of 6.03%K −1 was achieved at 323 K, indicating significant potential application value of this probe in the field of biological temperature measurement.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2022
·Vol. 105
·期 7
·4974-4985
·
IF 4.186
Hang Liu,Xiaofeng Zhao,Yuancheng Teng,Yuxiang Li,Xiayu Zheng,Shanlin Wang,Lang Wu,Pritam Kumar Panda,Rajeev Ahuja
LnPO 4 · 0.667H 2 O rhabdophane has been considered as a potential material for the precipitation of actinides from radioactive waste liquid, owing to its outstanding characteristics of high actinide bearing and easy synthesis in acid solutions. However, a comprehensive understanding of the actinide occupation and the precipitation response of rhabdophane to remove actinides has yet to be established. In this study, the effect of ions concentration and pH values on the detailed precipitation reaction of Ce x Nd 1- x PO 4 · 0.667H 2 O rhabdophane in acid solutions are systematically investigated. Some specific issues such as structural distortion and flexibility, and occupation mechanism are discussed by combining with experiments and density functional theory (DFT) calculation. The results reveal that ions concentration and pH values have a significant impact on the crystallization nucleation step before 12 h. The obtained removal rate of Nd 3+ is more than 99% in pH 1–5 solutions with the ions concentration of 0.05–0.1 mol/L. Moreover, incorporating Nd in CePO 4 · 0.667H 2 O rhabdophane will easily result in the lattice distortion in b -axis. DFT calculation and X-ray photoelectron spectroscopy (XPS) results reveal that Nd is preferentially incorporated in nonhydrated site to form a weaker binding energy of NdO 8 polyhedron.
研究领域:
材料科学
·
核化学与放射化学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS LETTERS
·
2016
·
IF 2.437
Junyu Ren,Xuzhao Zhang,Xiaotong Zhang,Jiayi Guo,Rui Cheng,Shiyi Guo
In this letter, the Nd 3+ : Ca 3 NbGa 3 Si 2 O 14 single crystals with high doping concentration (2 at%) were grown using the Czochralski pulling method. For the first time, the dielectric, elastic and piezoelectric properties of Nd 3+ : CNGS crystals were evaluated at room temperature. The electro-elastic coefficients obtained for CNGS at room temperature crystals were given. It is proved that Nd 3+ : CNGS crystals have larger dielectric constants, piezoelectric constants and elastic compliance, as compared with those of CNGS crystals. Also, the new data were presented on the temperature dependence of electro-elastic properties from 25 °C to 900 °C. It is shown that Nd 3+ : CNGS crystals have a favorable temperature stability and high mechanical quality factor Q within the temperature range of 25–600 °C.
研究领域:
材料科学
·
物理学
✓ 已验证
DOI
高影响因子
CRYSTENGCOMM
·
2024
·Vol. 26
·期 27
·3603-3608
·
IF 2.6
Wenfei Xun,Zhipeng Meng,Chuwei Xie,Suli Wu
808 nm excited Nd3+ doped upconversion nanoparticles (UCNPs) have become a new research hotspot due to their reduced thermal effect when applied in a water-rich system. Different from Tm3+-mediated energy migration upconversion of Tb3+, in this work, NaYF4:Yb/Tb@NaYF4:Yb@NaNdF4:Yb@NaYF4 core–shell–shell–shell nanoparticles were designed based on the Yb3+ sensitized cooperative energy-transfer process to realize photon upconversion. NaYF4:Yb served as the migration layer, separating the activator Tb3+ from the sensitizer Nd3+ and minimizing the deleterious cross-relaxation between them. At 40% Yb3+ doping concentration in the NaYF4:Yb layer, bright green luminescence was achieved under 808 nm excitation. Meanwhile, the presence of Yb3+ in the sensitization layer (NaNdF4:Yb) reduced Nd3+ cross-relaxation, leading to improved energy migration efficiency of Nd3+ → Yb3+. Finally, the incorporation of an inert NaYF4 shell resulted in a significant luminescence boost. These nanoparticles can be dispersed in water after surface modification and could be effectively excited after laser penetration of 3 cm of water, indicating the enormous potential of the designed UCNPs in the biological system.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Materials
·
2019
·
IF 2.689
Wang Xin,Zhao Haiyan,Li Angzhen,Tian Ke,Brambilla Gilberto,Wang Pengfei
In this letter, an Nd3+-doped compound fluorosilicate glass was successfully fabricated with the method of melt-quenching. Under the excitation of a 808 nm laser, enhanced near-infrared photoluminescence emission at the range from 1,065 to 1,140 nm was observed in the glass sample. To characterize its stability and resistance to environmental effects, transmission spectra at the range of NIR-MIR were measured under different environments, including humidity and temperature. In addition, the obtained fluorosilicate glass was also developed as a microsphere resonator by using CO2 laser heating method. When the diameter of the microsphere was controlled at 61.5 μm, coupling with a tapered fiber, single-multimode lasing in the wavelength range λ1,056–1,071 nm was achieved with a low lasing threshold of 1.5 mW. Compared to silica and phosphate glasses, this fluorosilicate glasses have lower phonon energy, which can reduce the probability of non-radiative transitions and improve the photoluminescence efficiency. Therefore, using it as the raw material, the developed microsphere resonator offers a high transition temperature and with a low lasing threshold, which are promising it for high performance sensing and detection applications.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2018
·
IF 8.806
Feng Ren,Lihua Ding,Hanghang Liu,Qian Huang,Hao Zhang,Lijuan Zhang,Jianfeng Zeng,Qiao Sun,Zhen Li,Mingyuan Gao
In-vivo intravital short wavelength infrared (SWIR, 1000–2300 nm) fluorescence imaging has attracted considerable attention in the imaging of tumor vasculature due to its low background, high sensitivity, and deep penetration. It can noninvasively provide dynamic feedback on the tumorigenesis, growth, necrosis and metastasis. Herein, monodisperse Nd 3+ -doped core-shell downconversion luminescent nanocrystals with strong emission in the second near-infrared (NIR II) window, strong temperature-dependent paramagnetism and fast attenuation to X-rays were prepared from ultra-small nanoclusters . The use of nanoclusters resulted in very uniform bright nanocrystals with a relative quantum yield comparable to the standard dye IR-26. These bright NIR nanocrystals were modified with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine- N -[methoxy(polyethylene glycol)-2000] to endow with excellent water-solubility, biocompatibility and a blood circulation half-life of 5.9 h. They were then successfully used to demonstrate the variation of tumor vasculature with tumor progression from tumorigenesis, growth, to necrosis in the subcutaneous breast tumor through the NIR II fluorescence imaging. They were also used as contrast agent of magnetic resonance imaging (MRI) and X-ray computed tomography (CT) imaging of tumor to provide complementary anatomic structure. Their great potential in NIR II imaging of tumor was further demonstrated with an orthotopic breast tumor. Their in-vivo biosafety was also investigated by hemanalysis and histological analyses.
研究领域:
生物医学工程
·
纳米医学
·
分子影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2016
·
IF 3.15
Haixia Zou,Fengmin Jin,Xiaoyan Song,Jinfeng Xing
The introduction of a thick shell structure has been widely used to enhance the emission intensity of upconversion nanoparticles (UCNPs). However, a thick shell could increase the distance between UCNPs and photosensitizers, which is not favourable to the generation of singlet oxygen ( 1 O 2 ) in photodynamic therapy (PDT) due to the low fluorescence resonance energy transfer (FRET) efficiency. In this study, we used a facile method to prepare UCNPs that the emission intensity could increase with the shell thickness decreasing, which facilitated the efficient FRET between UCNPs and photosensitizers. In detail, the Nd 3+ -doped UCNPs with different dopant concentration of Yb 3+ were prepared and characterized firstly. The I r/g (intensity of red luminescence to green luminescence) was tuned to increase largely by precisely controlling Yb 3+ concentration in core-shell, which could make UCNPs effectively activate methylene blue (MB). Then, a unique procedure was used to prepare NaYF 4 :Yb/Er/Nd@NaYF 4 :Nd (Yb 3+ :30%) core-shell nanoparticles with different shell thickness by tuning the amount of the core. The upconversion luminescence (UCL) intensity of those UCNPs enhanced dramatically with the shell thickness decreasing. Furthermore, UCNPs and MB were encapsulated into SiO 2 nanoparticles. FRET efficiency between UCNPs and MB largely increased with the shell thickness of UCNPs decreasing. Correspondingly, the efficiency of 1 O 2 generation obviously increased. We provided a new method to optimize the UCL intensity and FRET efficiency at the same time to produce 1 O 2 efficiently.
研究领域:
生物医学工程
·
纳米医学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Tingting Liu,Hong Lei
Abrasive is one of the most important factors in chemical mechanical polishing (CMP). In order to improve the polishing qualities of sapphire substrates, the novel Nd 3+ -doped colloidal SiO 2 composite abrasives were prepared by seed-induced growth method. In this work, there were a series of condensation reactions during the synthesis process of Nd 3+ -doped colloidal SiO 2 composite abrasives and the silica cores were coated by shells (which contains SiO 2 , Nd 2 Si 2 O 7 and Nd(OH) 3 ) via chemical bonds and hydrogen bonds in the Nd 3+ -doped colloidal SiO 2 composite abrasives, which made the composite abrasives’ core-shell structure more sTable Scanning electron microscopy (SEM) showed that Nd 3+ -doped colloidal SiO 2 composite abrasives were spherical and uniform in size. And the acting mechanisms of Nd 3+ -doped colloidal SiO 2 composite abrasives on sapphire in CMP were investigated. Time-of-flight secondary ion mass spectroscopy (TOF-SIMS) analysis and X-ray photoelectron spectroscopy (XPS) analysis demonstrated that the solid-state chemical reactions between the shells (which contained SiO 2 , Nd 2 Si 2 O 7 and Nd(OH) 3 ) of Nd 3+ -doped colloidal SiO 2 composite abrasives and the sapphire occurred during the CMP process. Furthermore, Nd 3+ -doped colloidal SiO 2 composite abrasives exhibited lower surface roughness and higher material removal rate (MRR) than the pure colloidal SiO 2 abrasives in the same polishing conditions, which was attributed to the solid-state chemical reactions between shells of Nd 3+ -doped colloidal SiO 2 composite abrasives and sapphire.
研究领域:
材料科学
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NON-CRYSTALLINE SOLIDS
·
2019
·
IF 2.6
S.J. Huang,Y.B. Xiao,J.L. Liu,Y. Ji,L.Y. Mao,W.C. Wang
In this work, a multicomponent GeO 2 –Sb 2 O 3 –BaO (BSG) glass is explored to assess its potential for 1.06 μm fiber lasers . The glass-forming region of BSG system is predicted and determined experimentally based on a thermodynamic method. Benefitting from the incorporation of Sb 2 O 3 , this system possesses an exceptionally large glass-forming region, as well as high density and refractive index , wide infrared transmission range and low phonon energy. Furthermore, an efficient near-infrared emission at 1064 nm from Nd 3+ has been realized in this oxide glass with relatively long measured lifetime (200.58 ± 1.24 μs) and large emission cross-section (3.015 ± 0.090 × 10 −20 cm 2 ), indicating that Nd 3+ -doped BSG glass is a promising candidate for laser application in 1.06 μm region.
研究领域:
光学材料
·
玻璃科学
·
激光物理
·
无机非金属材料
·
光子学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）