TOXICOLOGY
·
2024
·
IF 4.8
Jianan Zhai,Zhengguo Chen,Qi zhu,Zhifang Guo,Xiance Sun,Liping Jiang,Jing Li,Ningning Wang,Xiaofeng Yao,Cong Zhang,Haoyuan Deng,Shaopeng Wang,Guang Yang
Patulin (PAT), the most common mycotoxin, is widespread in foods and beverages which poses a serious food safety issue to human health. Our previous research confirmed that exposure to PAT can lead to acute kidney injury (AKI). Curcumin is the most abundant active ingredient in turmeric rhizome with various biological activities. The aim of this study is to investigate whether curcumin can prevent the renal injury caused by PAT, and to explore potential mechanisms. In vivo , supplementation with curcumin attenuated PAT-induced ferroptosis. Mechanically, curcumin inhibited autophagy, led to the accumulation of p62 and its interaction with Keap1, promoted the nuclear translocation of nuclear factor E2 related factor 2 (Nrf2), and increased the expression of antioxidant stress factors in the process of ferroptosis. These results have also been confirmed in HKC cell experiments. Furthermore, knockdown of Nrf2 in HKC cells abrogated the protective effect of curcumin on ferroptosis. In conclusion, we confirmed that curcumin mitigated PAT-induced AKI by inhibiting ferroptosis via activation of the p62/Keap1/Nrf2 pathway. This study provides new potential targets and ideas for the prevention and treatment of PAT.
研究领域:
毒理学
·
药理学
·
分子生物学
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHYTOCHEMISTRY
·
2021
·
IF 4.072
Xudong Zhang,Xing Huang,Yan Li,Faqing Tao,Qinshi Zhao,Weiqi Li
Polar auxin transport (PAT) is essential to control root growth. Flavonoids are widely thought to be PAT inhibitors leading to short root developments. However, we found that the flavonoids scutellarin and scutellarein , which both have a 6-hydroxyl group unlike the structure of known flavonoid-PAT-inhibitors, promote PAT in roots. They increase root length; rescue the short roots induced by the PAT-specific inhibitor TIBA; enhance the expression of the PAT mediators PIN1 , PIN2 and AUX1 ; increase the auxin concentration at the quiescent center; and change the distribution of the meristem organizer WOX5. In contrast, rutin and naringenin , which have no 6-hydroxyl group and have different structural features in B-ring, shows the opposite/no effects. Our evidence suggests that flavonoids with and without a 6-hydroxyl group might result in opposite effects on root growth and thus act as chemical switches in regulating PAT.
研究领域:
植物学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Hongfei Gao,Luke Wen,Yuhua Wu,Xiaohong Yan,Jun Li,Xiaofei Li,Zhifeng Fu,Gang Wu
A highly sensitive electrochemiluminescent (ECL) immunoassay targeting PAT/bar protein was facilely developed for genetically modified (GM) rapeseed detection using carbon nanoparticles (CNPs) originally prepared from printer toner. In this work, CNPs linked with antibody for PAT/bar protein were used to modify a working electrode. After an immunoreaction between the PAT/bar protein and its antibody, the immunocomplex formed on the electrode receptor region resulted in an inhibition of electron transfer between the electrode surface and the ECL substance, thus led to a decrease of ECL response. Under the optimal conditions, the ECL responses linearly decreased as the increase of the PAT/bar protein concentration and the GM rapeseed RF3 content in the ranges of 0.10–10 ng/mL and 0.050–1.0%, with the limits of detection of 0.050 ng/mL and 0.020% (S/N = 3). These results open a facile, sensitive, and rapid approach for the safety control of agricultural GM rape.
研究领域:
生物技术
·
食品科学
·
环境监测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Sheng Zhang,Zhenyang Liu,Linlin Mao,Jian Wu,Di Zhang,Ruiyuan Liu,Li Qi
High quality visualization of live mammalian embryo is an important requirement for studying fetal development. Photoacoustic tomography (PAT) and optical coherence tomography (OCT) are two advanced imaging modalities that have been utilized for embryonic imaging separately. However, high contrast, multiscale, and deep tissue imaging of embryos in vivo remains challenging. Here, we demonstrate multimodal contrast-enhanced imaging of live embryos by gold nanostar-meditated near-infrared I (NIR-I) PAT and near-infrared II (NIR-II) OCT. We investigate intravenous and intravaginal administration of gold nanostars, and significant enhancement of signal, image contrast, and imaging depth are achieved for both PAT and OCT. Our findings may facilitate detailed studies of the morphological and functional changes during embryonic development.
研究领域:
生物医学工程
·
成像科学
·
发育生物学
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2025
·Vol. 36
·期 11
·e70401
·
IF 3.4
Jie Tang,Yajun Luo,Bin Wang,Zidan Chen,Lei Wu,Ping Shu,Yongxu Xu,Weijie Li,Xiang Lv,Wenjun Zhang,Miao Lu,Hui Ju,Jin Luo
Suspension polymerization may play a crucial role in synthesizing multiblock copolymers for functional architectures. In this study, water (H 2 O) was employed as the continuous dispersion medium, hydrophobic benzyl methacrylate (BzMA) was initially polymerized in toluene (MB) droplets containing oil-soluble initiator under controlled MB volume. Subsequently, glycidyl methacrylate (GMA) was introduced in a controlled manner, where it preferentially accumulated at the MB droplet interface due to its intrinsic properties and polymerization-modulating effects. Remarkably, the spatially confined segregation enabled sequential polymerization, where initial homopolymerization occurred within BzMA domains prior to initiating GMA polymerization at the interface, ultimately yielding the diblock (PGMA-b-PBzMA, PGB) copolymers and oil-soluble (PBzMA, PB) byproducts. Moreover, the rational functionalization and controlled assembly of the produced PGB copolymers not only effectively eliminated byproduct interference, but also facilitated the construction of versatile advanced architectures with programmable properties. Collectively, the aforementioned continuous feeding suspension polymerization (CFSP) strategy significantly reduces time and cost compared to conventional chain-extension methods requiring strict kinetic control.
研究领域:
高分子化学
·
材料科学
·
高分子工程
·
纳米材料
·
功能高分子
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2025
·Vol. 36
·期 11
·e70403
·
IF 3.4
Wenming Yang,Xiangpeng Shi,Xiaoqiang Chen,Yuanzheng Cai,Yi Ji,Yunfei Cao,Wanzhen Xu
The presence of sulfonamide antibiotic residues, such as sulfadiazine (SDZ), in aquatic ecosystems presents significant ecological risks, including the emergence of antibiotic resistance. Therefore, the development of precise and sensitive detection methods is of paramount importance. This study focuses on the design of a highly sensitive sensor for detecting SDZ by exploring the effects of quantum dot (QD) emission wavelength, particle size, and surface characteristics on sensor performance. Green, yellow, and red-emitting cadmium telluride (CdTe) QDs were synthesized through systematic adjustments in the molar ratio of Cd 2+ to Te, reflux time, and solution pH. These QDs were subsequently incorporated into silica nanoparticles (NH 2 -SiO 2 ) via molecular imprinting technology to fabricate a multicolor fluorescent imprinted sensor. The results indicated that the sensor incorporating green-emitting QDs (MIPs@g-QDs@SiO 2 ) exhibited the best performance, with a detection limit of 10.53 nM, a fluorescence quenching constant of K Sv , g = 4030 M − 1 $$ {K}_{Sv,g}=4030\ {\mathrm{M}}^{-1} $$ , and a linear detection range of 10–60 μmol·L −1 . In comparison, the yellow and red-emitting QD sensors displayed higher detection limits of 30.58 and 68.52 nM, with quenching constants of K Sv , y = 3700 M − 1 $$ {K}_{Sv,y}=3700\ {\mathrm{M}}^{-1} $$ and K Sv , r = 3360 M − 1 $$ {K}_{Sv,r}=3360\ {\mathrm{M}}^{-1} $$ , respectively. The sensitivity of the green-emitting QD sensor is attributed to its smaller particle size, which results in a larger specific surface area and enhanced surface effects, thereby increasing the fluorescence intensity range. Moreover, fluorescence quenching and selective adsorption experiments demonstrated that MIPs@g-QDs@SiO 2 exhibited excellent selective adsorption properties for SDZ, contributing to its enhanced fluorescent response.
研究领域:
环境监测
·
分析化学
·
纳米材料
·
传感器与生物传感器
·
抗生素检测
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2025
·Vol. 36
·期 11
·e70404
·
IF 3.4
Yuning Gong,Houfeng He,Haoran Zheng,Ce Shang,Tian Feng,Yibo Yang,Hongyang Wang,Jiu Zhao
Under the dual-carbon policy, the extraction of heavy oil faces significant challenges. Microbial enhanced oil recovery (MEOR), with its sustainability and environmental friendliness, continues to hold a pivotal position. This study proposes an immobilized carrier material (SA/L hydrogel microspheres) capable of targeted microbial release. By leveraging the hydrogel properties of sodium alginate (SA) and the oil solubility of lecithin, the composite material encapsulates microorganisms and is fabricated into microspheres. These microspheres are applicable for reducing the chemical oxygen demand (COD) in oilfield wastewater and decreasing the viscosity of heavy oil, thereby enhancing heavy oil recovery. Positive experimental results indicate that the inoculation of Bacillus subtilis is most efficient at 5%–7%, with an optimal pH range of 6.5–7.0, salinity not exceeding 5000 ppm, and a temperature around 40°C. COD reduction experiments reveal that with SA/L hydrogel microspheres, a mere 5% inoculation rate can achieve a reduction exceeding 60%, and a 7% inoculation rate can surpass 80%. Viscosity reduction experiments for heavy oil demonstrate that with SA/L hydrogel microspheres, a 5% inoculation rate can achieve a viscosity reduction rate of up to 81.6%, with the greatest reduction in saturated hydrocarbons followed by aromatic hydrocarbons. Finally, experiments confirm a recovery enhancement of 23.0%, indicating that SA/L hydrogel microspheres as immobilized carriers are significant.
研究领域:
环境工程
·
石油工程
·
微生物生物技术
·
可持续能源
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2025
·Vol. 36
·期 11
·e70427
·
IF 3.4
Liu Le,Bai Jingyi,Fangting Mo,Wang Yan,Yang Haoting,Zirong Luo,Na Kong,Zhang Jizhen,Zhao Pengfei,Li Shuang,Yanqiu Shao,Jinlong Tao
Concentrated natural rubber latex is a vital industrial and biomedical material, but its production generates raw skim latex (RSL), a by-product with low dry rubber content and high nonrubber components (NRCs) that limit its utility. Conventional concentration methods face challenges like membrane fouling, high cost, and complex operation. To address this, we developed a green concentration strategy using superabsorbent polymer (SAP) beads. This method simultaneously absorbed water and selectively removed NRCs from RSL. After a single treatment, the total solids content of the concentrated latex increased to 37.24%, while the NRCs content was significantly reduced to 5.21%. This reduction in NRCs altered the polymer network, leading to a remarkable tensile strength of 22.39 MPa in the vulcanized films. Furthermore, the SAP beads maintained high efficiency over five reuse cycles. This work establishes a simple, cost-effective, and sustainable process for producing high-value concentrated skim latex.
研究领域:
材料科学
·
高分子科学
·
可持续工程
·
工业生物技术
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2025
·Vol. 36
·期 12
·e70464
·
IF 3.4
Hanxin Zhang
Enhancing the fire safety of thermoplastic polyurethane (TPU), a polymer prized throughout the automotive industry, without degrading its mechanical properties is a critical industrial challenge. While two-dimensional zirconium phosphate (ZrP) nanosheets offer promising flame-retardant capabilities, their intrinsic aggregation tendency severely compromises their effectiveness in polymer matrices. Herein, ZrP nanosheets were functionalized via the surface self-assembly of a bio-based nitrogen-phosphorus supramolecule derived from phytic acid (PA) and chitosan (CS), yielding the novel nanohybrid PC@ZrP. This nanohybrid's exceptional dispersion and interfacial compatibility within the TPU matrix enable a remarkable dual functionality. At 1 wt% loading, the TPU/PC@ZrP nanocomposite achieves a 42.6% enhancement in tensile strength alongside a 6.1% improvement in elongation at break. The material's fire safety is also substantially enhanced: a 3 wt% incorporation reduces the peak heat release rate and total heat release by 35.5% and 22.6%, respectively, while effectively suppressing smoke and toxic gas emissions. Mechanistic investigations revealed that this performance stems from synergistic flame-retardant actions in both the condensed and gas phases. This work provides a robust, eco-friendly strategy for creating multifunctional additives that bolster the fire safety and mechanical strength of polymer nanocomposites, paving the way for safer materials in demanding sectors like automotive manufacturing.
研究领域:
材料科学
·
聚合物纳米复合材料
·
消防安全工程
·
可持续化学
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2025
·Vol. 36
·期 12
·e70447
·
IF 3.4
Xinyi Bian,Yiyan Zhang,Ruosi Yan,Zhenhong Chen,Bao Shi,Lixia Jia,Xiayun Zhang
In this paper, puncture-resistant composite fabrics (ILSA and CILSA) are prepared by combining ionic-based shear thickening fluids (ILSTF and CILSTF) with aramid fabrics through the method of impregnation. Ionic-based shear thickening fluids significantly enhance the frictional performance between the yarns of the fabric. The maximum friction between the yarns in the composite material is 6.56 times that between the yarns in pure fabric at a pull-out speed of 150 mm/min. The composite materials not only have excellent puncture-resistant performance but also have sensitive sensing performance. The optimal ILSA knife-head puncture force increased by 2.15 times and spike-head puncture force increased by 6.32 times compared to the pure fabric. Moreover, CILSA can not only accurately respond to stress changes ranging from small to large, but also to changes in the bending state of materials, featuring excellent sensitivity and stability. These characteristics indicate broad application prospects of this material in smart textiles and protective equipment, where adaptive response to mechanical stimuli is crucial.
研究领域:
材料科学
·
智能纺织品
·
防护材料
·
传感器与传感技术
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2019
·Vol. 30
·期 5
·1269-1278
·
IF 2.162
Fu-Ru Kang,Jun Deng,Dong-Sheng Jiao,Li-Qun He,Wei-Feng Wang,Zhi-Chao Liu
A novel and versatile route for fabricating flame-retardant microcapsules via microfluidics technology is reported. The flame-retardant microcapsules were prepared with a dimethyl methylphosphonate (DMMP) core and an ultraviolet-curable (UV-curable) polysiloxane shell. Furthermore, a UV-curable polysiloxane was synthesized. The synthesis mechanism of UV-curable polysiloxane and the curing mechanism of flame-retardant microcapsules were analyzed. To verify that DMMP was encapsulated in the microcapsules, X-ray fluorescence was used before and after microencapsulation. The resulting microcapsules were well monodispersed and exhibited a good spherical shape with a smooth surface. In addition, the size of the microcapsules decreased dramatically with an increasing flow-rate ratio of the middle-/inner-phase or outer-phase flow rate. The thermal stability of the microcapsules was worse than shell materials but superior to DMMP. Silicone foams (SiFs) with microcapsules prepared using a dehydrogenation method achieved a relatively higher limiting oxygen-index value than the pure SiF, which indicated that the microcapsules could enhance the flame retardation of SiFs effectively. Because of the polysiloxane shell, the microcapsules had good compatibility with SiFs, and the influence of microcapsules on the mechanical properties of SiFs was unremarkable.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2019
·Vol. 31
·期 4
·759-771
·
IF 2.162
Ying Cao,Jie Cao,Jiatian Zhang,Dandan Zhang,Meng Li,Yiting Xu,Kaibin He,Guorong Chen,Conghui Yuan,Lizong Dai
The azobenzene-based amphiphilic copolymers have drawn significant attention as a kind of multi-responsive smart materials. The demand on deeper investigation of how the azobenzene group influences the micelles formation and light-responsive behavior on molecular level is very urgent. In this article, multi-responsive block copolymers, poly (acrylic acid)-block-poly[4'-[[(2-Methacryloyloxy)ethyl]ethylainino]azobenzene-co-poly (ethylene glycol) methyl ether methacrylate] (PAA-b-P (AzoMA-co-PEGMA)), with pH-, light- and reduction-responsiveness were synthesized by the monomers of AzoMA, PEGMA and acrylic acid via reversible addition-fragmentation chain transfer polymerization (RAFT). The amphiphilic block copolymer presented aggregation-induced emission effect, and it was pH, light, and reduction responsive. The results showed that the micelle size decreased with the decreasing of pH within a certain range. However, the particle size of micelles increased significantly when the pH was 4. Once adding reduction agent, the micelles were disassembly. Fluorescent molecule of Nile red was selected as a hydrophobic guest molecule to study the properties of encapsulating and releasing abilities of block copolymer micelles for guest molecules. The results showed that the loading capacity of three kinds of copolymer micelles was closely related to the aggregates formed by the hydrophobic block, mainly azobenzene block. Besides, the block copolymer micelles could release a certain amount of Nile red under the irradiation of UV light, the reduction with Na 2 S 2 O 4 as reductant, and the exposure to alkaline environment. The mechanism of how the different status of azobenzene group influenced the self-assembly and multi-responsive behavior was explored on molecular level.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）