PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2021
·Vol. 38
·期 7
·2100062
·
IF 3.31
Pengfei Yang,Zhihuan Zhao,Shasha Yang,Jianying Lin,Jimin Fan,Bing Zhang
In this study, a chemotherapy-photothermal synergistic anti-tumor system is constructed. Both W 18 O 49 @R-C and PEG-W 18 O 49 @R-C synthesized by hydrothermal method show the potential of photothermal therapy (PTT). The structure of reflux-carbon is bubble-like spherical and W 18 O 49 @R-C obtained by hydrothermal synthesis will cause bubble collapse due to the formation of crystal W 18 O 49 ; thus, the particle size decreases sharply. Furthermore, the photothermal stability of PEG-W 18 O 49 @R-C is higher than that of W 18 O 49 @R-C, and ζ-potential measurement indicates that PEG-W 18 O 49 @R-C has excellent dispersion characteristics. The test of drug loading and drug release performance show that PEG-modified W 18 O 49 @R-C has superior performance on drug loading amount and release capacity. In the synergistic anti-tumor process, the cancer cell viability after co-incubating with PEG-W 18 O 49 @R-C+DOX . HCl (with 808nm) is only 16.6%. These results indicate that PEG-W 18 O 49 @R-C has potential in the treatment of cancer by a combination of PTT and chemotherapy.
研究领域:
肿瘤学
·
材料科学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LIPOSOME RESEARCH
·
2025
·
IF 4.3
Qinyang Hua,Qilong Wang,Xue Wang,Xia Jiang,Mingjie Gong,Jiaying Li,Tingyuan Li,Xiaowen Wang,Xia Cao,Jiangnan Yu,Elmurat Toreniyazov,Bin Zong,Ximing Xu,Feng Shi,Michael Adu-Frimpong
The clinical application of Isoquercitrin (IQ) is limited by its low water solubility and short retention time in the body, despite its diverse pharmacological effects. To address these issues, we prepared polyethylene glycol (PEG)-modified IQ liposomes (IQ-L) using the thin film dispersion method and optimized the formulation through a combination of One Factor at a Time (OFAT) method and response surface experiments. Characterization of the IQ-L that was prepared using the optimal formulation revealed a particle size of 185.48 nm, a polydispersity index of 0.252, a zeta potential of −33.88 mV, and an impressive encapsulation efficiency of 97.84%. In vitro release studies showed a significantly higher cumulative release rate for IQ-L compared to free IQ. Pharmacokinetic evaluations in rats demonstrated a 4.54-fold increase in the area under the concentration-time curve, a 1.63-fold prolongation of the half-life, and a 2.07-fold increase in peak concentration for IQ-L compared to unmodified IQ. Moreover, assessments of renal function in a mouse model indicated promising therapeutic effects. In summary, the PEG-modified liposome system greatly improved the solubility and in vivo retention time of IQ, thus making it a potential clinical agent for the treatment of chronic kidney disease (CKD).
研究领域:
药剂学
·
肾脏病学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xiaopei Ma,Yaodong Liu,Jun Wang,Hui Liu,Gang Wei,Weiyue Lu,Yu Liu
Strong precorneal clearance mechanisms including reflex blink, constant tear drainage, and rapid mucus turnover constitute great challenges for eye drops for effective drug delivery to the ocular epithelium. In this study, cyclosporine A (CsA) for the treatment of dry eye disease (DED) was selected as the model drug. Two strategies, PEGylation for mucus penetration and cationization for potent cellular uptake, were combined to construct a novel CsA nanosuspension (NS@lipid-PEG/CKC) by coating nanoscale drug particles with a mixture of lipids, DSPE-PEG2000, and a cationic surfactant, cetalkonium chloride (CKC). NS@lipid-PEG/CKC with the mean size ∼173 nm and positive zeta potential ∼+40 mV showed promoted mucus penetration, good cytocompatibility, more cellular uptake, and prolonged precorneal retention without obvious ocular irritation. More importantly, NS@lipid-PEG/CKC recovered tear production and goblet cell density more efficiently than the commercial cationic nanoemulsion on a dry eye disease rat model. All results indicated that a combination of PEGylation and cationization might provide a promising strategy to coordinate mucus penetration and cellular uptake for enhanced drug delivery to the ocular epithelium for nanomedicine-based eye drops.
研究领域:
药剂学
·
眼科医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2019
·
IF 2.705
Jiang-Tao Wang,Wei Zhang,Wan-Bi Wang,Yong-Juan Wu,Ling Zhou,Feng Cao
Background Tungsten disulfide (WS 2 ), which enjoyed a good potential to be a promising clinical theranostic agent for cancer treatment, is still subject to the tedious synthesis procedure. Methods Here, we reported a one-pot ‘bottom-up’ hydrothermal strategy for the fabrication of PEGylated WS 2 nanoparticles (NPs). The WS 2 -PEG nanoparticles were characterized systematically. The CT imaging and photothermal therapy against tumor as well as biosafety in vitro and in vivo were also investigated. Results The obtained WS 2 -PEG NPs enjoyed obvious merits of good solubility and favorable photothermal performance. WS 2 -PEG NPs exhibited desirable photothermal ablation ability against cancer cells and cancer cell-bearing mice in vitro and in vivo. MTT assay and histological analysis demonstrated the low cytotoxicity and biotoxicity of WS 2 -PEG NPs, providing a valid biosafety guarantee for the coming biomedical applications. In addition, thanks to the obvious X-ray attenuation of W atom, the WS 2 -PEG NPs can also be served as a favorable contrast agent for CT imaging of tumors. Conclusion WS 2 -PEG NPs has enjoyed a good potential to be a promising clinical CT-guided photothermal therapeutic agent against cancers.
研究领域:
肿瘤学
·
材料科学
·
医学影像学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscience and Nanotechnology Letters
·
2017
·Vol. 9
·期 4
·556-561
·
IF 1.889
Hu Jun,Dehsorkhi Ashkan,Al-Jamal Wafa T.,Zhang Yan,Chen Siying,Yang Chuanyu,Tan Dan,Zhao Qing,Yang Chang,Wang Yonglin
We reported the photothermal studies on the PEGylated Fe3O4 nanoparticles. In our study, we prepared a series of PEGylated Fe3O4 nanoparticles with different formulations and found that all the PEGylated Fe3O4 nanoparticles
have both the photothermal conversion effect and magnetic hyperthermia. We first tried to illustrate the importance of photothermal effect and magnetic heating in the hyperthermia of Fe3O4 nanoparticles, and describe the relationship between the structures and functions.
Among these samples, there were two different structures. One is a similar colloidal nanostructure, while the other is a typical nanoparticle structure. Both of them have the similar ultraviolet-visible absorption spectra, Fourier transform infrared spectra and X-ray diffraction patterns.
However, the second nanoparticles have higher photothermal conversion efficiency and magnetic resonance imaging contrast than the first colloidal nanostructures. Moreover, by transmission electron microscopy, we found that when the core diameter was in the range of 19–20 nm, the temperature
change was above 28 C by photothermal effect, while the magnetic heating was low. All these results not only help us have more comprehensive understanding of Fe3O4 nanoparticle properties, but also provide a rational theoretical support for applying Fe3O4
nanoparticles as a suitable candidate in the photothermal treatment.
研究领域:
纳米医学
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
STARCH-STARKE
·
2011
·Vol. 63
·期 10
·625-631
·
IF 1.261
Jiwen Wang,Wentao Zhai,Wenge Zheng
The main target of this study is to synthesize one kind of granular cold-water-soluble (GCWS) starch by grafting poly(ethylene glycol) (PEG) segments onto the surface of native starch granules. It is found that the grafting process could introduce long PEG chains onto the granule surface, resulting in the presence of special micropits on the granule surface, as characterized by SEM. The cold water solution test verified that the resultant PEG-grafted corn starches exhibited excellent cold-water-solubility. The XRD analysis and further polar optical micrograph (POM) observation indicated that the crystallites structure inside the PEG-grafted corn starches was fully preserved, since no gelatinization process was involved. The present study provides a new train of thought that we can adjust the physiochemical properties of starch granules with proper surface modification.
研究领域:
食品科学
·
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
Particuology
·
2021
·
IF 3.067
Shan Qiao,Mingmin Li,Jiangyue Yu,Sainan Zhang,Dong Yan,Zhenjie Zhang,Yao Chen
The assembly of biomacromole particles with artificial solid matrixes to fabricate hybrid composites has been demonstrated as an efficient strategy to promote both components’ applications. Elaborating matrixes as well as appropriate assembly method is essential for optimal performances of the obtained natural-artificial composites. Herein, we fabricated the Cyt c @COF-42-B microcapsule through a sacrificial templating method and researched their adjustable biocatalysis by precisely adjusting the microenvironments of these assembled enzyme@COF particles. As a result, the hydrophobicity and mass transfer of the COF microcapsule can be controlled by modifying the different amounts of PEG moieties, thus improving the composite's bioactivity. We found that compared with pristine Cyt c @COF-42-B without PEG, the Cyt c @COF-42-B-PEG exhibited a ∼2.2 times higher activity. This study provides a significant step toward designing customizable functional natural-artificial composites for enhanced biomacromolecule's activity.
研究领域:
材料科学
·
生物化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2018
·
IF 4.244
Xin-Yue Chen,Wei Ha,Yan-Ping Shi
In this study, the asymmetrically modified gold nanoparticles (AuNPs) with relatively large size are proposed for highly sensitive detection of melamine in raw milk. At first, we found that the sensitivity of colorimetric detection of melamine based on the conventional citrate-stabilized AuNPs could be significantly increased (limit of detection by visual observation: from 1 μmol L −1 to 1 nmol L −1 ) via enlarging the size of AuNPs (from 13 to 42 nm). However, the large-sized AuNPs are unstable in the solution, and the accuracy of relevant aggregation-based colorimetric detection method is dramatically decreased due to the rapid evanishment of the color of solution caused by the precipitation of large-scaled AuNPs aggregates after introducing melamine. In view of this limitation, the stabilizing agent polyethylene glycol (PEG) is introduced onto the selected area at the surface of AuNPs to stabilize the large-sized AuNPs sensor and further adjust the aggregation behavior in an oriented and controllable manner. As a result, the addition of melamine into asymmetrically PEGylated AuNPs with large size could still induce a color change from purple to blue, but the color change could be maintained in aqueous solution for a long time. This improvement is mainly caused by forming stable and oriented oligomers of AuNPs taking advantage of the asymmetrical modification of AuNPs with PEG chain in this system. Such a way of aggregation leads to remarkably enhanced long-term stability and an at least 2 orders of magnitude wider dynamic detection range (1.05 nmol L −1 to 1 mmol L −1 ) compared with conventional AuNPs sensors. Finally, such a novel asymmetrically modified AuNPs sensor is successfully applied to detect melamine in the raw milk with the satisfactory spiked recovery from 99.6% to 103.7% and RSD of about 3.0%. This work provides a sensitive and reliable method to detect melamine in pretreated milk, indicating a new avenue to make innovation on colorimetric sensors for real sample detection.
研究领域:
分析化学
·
食品科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Toxicology Research
·
2016
·Vol. 5
·期 5
·1371-1379
·
IF 2.161
Xu Hui,Liu Meiying,Lan Ming,Yuan Huaying,Yu Weijen,Tian Jianwen,Wan Qing,Zhang Xiaoyong,Wei Yen
Carbon nanotubes (CNTs) have been widely examined for biomedical applications. However, surface functionalization of CNTs with polymers is often required to improve their application performance. To obtain these CNT-based polymer nanocomposites, surface-initiated polymerization strategies are generally adopted. However, all of these methods rely on the surface oxidation of CNTs, which is a rather complex and time-consuming procedure, and involves hazardous reagents. In this work, a facile and efficient bio-inspired strategy was developed for surface PEGylation of CNTs via a combination of mussel-inspired chemistry and the Michael addition reaction. The potential biomedical applications of these PEGylated CNTs were evaluated for intracellular delivery of a normally used anticancer drug (Doxorubicin hydrochloride). Two steps were involved in this strategy, which included the surface coating of CNTs with polydopamine (PDA) through self-polymerization of dopamine, and a Michael addition reaction between the PDA-coated CNTs (CNT-PDA) and amino-functionalized polymers, which were obtained by free radical polymerization using poly(ethylene glycol) methyl methacrylate and N-(3-aminopropyl) methacrylamide as monomers. Results suggested that these PEGylated CNTs are well dispersed in aqueous solution and showed improved biocompatibility toward cancer cells. On the other hand, we also demonstrated that DOX can be effectively loaded on these PEGylated CNTs and delivered into cells for cancer treatment. More importantly, this strategy can also be utilized for surface modification of many other materials with different polymers due to the strong and universal adhesion of PDA and designability of polymerization. Therefore, this method should be of great interest for the fabrication of multifunctional nanocomposites for biomedical applications.
研究领域:
材料科学
·
生物医药工程
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2020
·
IF 0.936
Feng-Zhi CUI,Jian-Hua LIU,Yang LIU,Bi-Ying YUAN,Xue GONG,Qing-Hai YUAN,Ting-Ting GONG,Lei WANG
Molecular imaging (MI) techniques have extremely significant effect on the diagnosis and prognosis of diseases, such as gastrointestinal (GI) tract-related diseases. Furthermore, nanomaterials as contrast agents have attracted a great deal of research attention, due to their rational fabrication and biomedical. Herein, we reported a facile process to synthesis PEGylated BaGdF 5 nanoparticles via a one-pot solvothermal route as CT/MRI dual-modal contrast agents for in vivo imaging of GI tract. Compared to the commercially used iodine contrast agents, the well-prepared nanoparticles exhibited enhancement in computed tomography (CT) imaging. In the presence of Gd, nanoparticles could also be used in magnetic resonance imaging (MRI). PEGylated BaGdF 5 nanoparticles were characterized by transmission electron microscopy (TEM), X-ray powder diffraction analysis (XRD), Fourier transform infrared (FT-IR) spectroscopy and thermogravimetric analysis (TGA). Besides, MTT assay revealed that the prepared nanoparticles proved to be low toxicity and high biocompatibility for Hela cells. Hemolytic assay illustrated nanoparticles possess favorable hemocompatibility. H & E (Hematoxylin and Eosin) histological staining assessed long-term toxicity of oral PEGylated BaGdF 5 nanoparticles, and the results showed that the nanoparticles had overall safety for GI tissue with comparatively high compatibility. Based on above results, PEGylated BaGdF 5 nanoparticles were admired multi-functional contrast agents to apply in CT and MRI imaging with prominent prospects.
研究领域:
医学影像学
·
纳米医学
·
分子影像
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 7
·3025-3040
·
IF 5.251
Lihong Sun,Qian Li,Lei Zhang,Huihui Chai,Ling Yu,Zhigang Xu,Yuejun Kang,Peng Xue
Stimuli-responsive therapeutic nanosystems exhibit enhanced selectivity and higher biosafety for cancer theranostics via recognizing exogenous or endogenous tumor-associated factors. Herein, we developed a multifunctional nanocomplex (Bi2Se3@PEG/DOX/Ce6 nanocapsules, or BPDC NCs in brief) which was constructed by loading chlorin e6 (Ce6) and doxorubicin (DOX) into PEGylated hollow bismuth selenide nanocapsules. Upon administration of BPDC NCs, composite laser irradiation can effectively activate the local hyperthermia generation and the yield of cytotoxic reactive oxygen species (ROS). In another aspect, on-demand drug release can be triggered in a mild acidic tumor microenvironment or by thermal shock. Moreover, imaging and navigation with respect to infrared thermography, computed tomography (CT) and fluorescence imaging may potentially monitor the biodistribution of BPDC NCs, thanks to the local hyperthermia generation, fluorescence emission of Ce6 and high Z-element of bismuth. Finally, we demonstrated tumor site-specific photothermal therapy (PTT), photodynamic therapy (PDT) and chemotherapeutic effects for highly efficacious tumor suppression with minimized systemic toxicity. Taken together, these findings indeed provide insights that can broaden the application of Bi2Se3 nanocapsules for cancer management and precision medicine.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2015
·
IF 8.557
Tao Bao,Wenyan Yin,Xiaopeng Zheng,Xiao Zhang,Jie Yu,Xinghua Dong,Yuan Yong,Fuping Gao,Liang Yan,Zhanjun Gu,Yuliang Zhao
Engineering design of plasmonic nanomaterials as on-demand theranostic nanoagents with imaging, drug carrier, and photothermal therapy (PTT) functions have profound impact on treatment of cancer. Here, a facile ‘one-pot’ template-free hydrothermal route was firstly developed for synthesis of plasmonic oxygen deficiency molybdenum oxide hollow nanospheres functionalized by poly(ethylene glycol) (PEG-MoO 3–x HNSs). The as-prepared PEG-MoO 3–x HNSs not only have good biocompatibility but also exhibit obvious localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region. Especially, due to its intrinsic mesoporous properties and effective photothermal conversion efficiency upon 808-nm NIR laser irradiation, the PEG-MoO 3–x HNSs can be applied as a pH/NIR laser dual-responsive camptothecin (CPT) drug delivery nanoplatform for chemotherapy as well as PTT to cancer cells. A remarkably improved synergistic therapeutic effect to pancreatic (PANC-1) tumor-bearing mice was obtained compared to the result of chemotherapy or PTT alone. Apart from its application for drug delivery, the PEG-MoO 3–x HNSs can also be employed as an effective contrast nanoagent for photoacoustic (PAT) imaging because of its high NIR absorption , making it promising as a theranostic nanoagent for PAT imaging-guided chemo-photothermal combinational cancer therapy in the nanomedicine field.
研究领域:
生物医学工程
·
肿瘤治疗
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）