JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Liya Fan,Wenxiang Wang,Xiaoyan Zhao
Poly (p-dioxane) (PPDO) as an absorbable suture exhibits good flexibility and tensile strength. Loading drugs through the immersion method will accelerate the hydrolysis of PPDO and affect its mechanical properties. In order to improve the drug loading performance of the PPDO suture and maintain its excellent mechanical stability, biodegradable material polylactic acid (PLA) was selected as the coating layer. The PLA fiber membrane with a porous structure was prepared by electrospinning, and nanosilver particles (Ag NPs) were loaded onto the membrane by in situ reaction. Subsequently, PLA@Ag and PPDO fibers were woven together to form PLA@Ag/PPDO composite yarn. The sustained-release ability, mechanical property, antibacterial, and cytotoxicity of the composite wire were further investigated. The results showed that the equilibrium release of Ag NPs from PLA@Ag/PPDO in phosphate buffer saline (PBS) was 0.84 mg/g, and the release equilibrium time was 8 h. The knotting strength of the composite wire increased by 17.8% compared to PPDO without a coating layer. Woven sutures presented significant antibacterial effects against S. aureus . The biocompatibility evaluation of human immortalized keratinocytes (HaCaT) demonstrated its safety in use. This work provides an effective technical method for the preparation of mechanically stable and functionalized absorbable sutures.
研究领域:
生物材料
·
生物医学工程
·
高分子科学
·
纳米技术
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Jinxue Cheng,Jiulin Bai,Junyu Guo,Xiaoliang Yu,Zhi Fan,Minjie Guo,Bowen Cheng
The growing high standard of people’s wear has put forward requirements for fabrics, and multifunctional fabrics have been developed precisely in response to the requirements of the times. However, the incineration of waste fabrics produces a large amount of pollutants, resulting in a massive waste of resources and environmental pollution. Herein, the degradable nanofiber yarns (NYs) with self-cleaning properties were fabricated by in situ growth of SiO2 nanoparticles on the surface of the electrospun poly(p-dioxanone) (PPDO) NYs using the Stöber method. Then, the PPDO NYs were blended with carbon fibers and the PPDO/SiO2 NYs with themselves to form the Janus PPDO fabrics, respectively. The Janus PPDO fabric offered asymmetric wettability and dual personal thermal management properties. The PPDO/C side of the Janus PPDO fabric provided 65.8 °C at 1.5 V or 58.5 °C under one sunlight intensity for radiative heating. The PPDO/SiO2 side exhibited high solar reflectivity (81.8%) and mid-infrared (MIR) emissivity (99.1%), which reduced the skin temperature by 4.6 °C, resulting in radiative cooling. Moreover, the Janus PPDO fabrics display an excellent electromagnetic interference (EMI) shielding performance (53.3 dB). Therefore, yarn-based degradable Janus fabric has a promising future in multifunctional wearable products.
研究领域:
材料科学
·
环境科学
·
纺织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2025
·
IF 2.4
Wenxiang Wang,Yujie Zhao,Cuilian Yi,Xiaoyan Zhao
Poly(p-dioxanone) (PPDO) is an important biodegradable material used for absorbable surgical sutures. In order to expand the application of PPDO in tissue repair, this work employed melt spinning to prepare PPDO monofilaments and further processed them into PPDO fiber tubes via three-dimensional (3D) weaving technology. The woven PPDO fiber tube exhibited the excellent mechanical stability. After being stretched by 50% of its own length 30 times, its resilience remained 87%. The woven PPDO material achieves effective control of drug release compared to the release behaviors of PPDO monofilament and PVA carrier. The release rate of antibiotics (tetracycline hydrochloride and vancomycin) could reach 99% at 37.5 °C. The release profiles were well-fit by a first-order kinetic model. The sample loaded with tetracycline hydrochloride showed 99% inhibition rate against S.aureus. The degradation test in vitro showed that the mechanical property of woven PPDO fiber tube was relatively stable within one week. Due to the hydrolysis of ester bonds in PPDO, the tensile strength of the sample decreased by 50% at two weeks. The results of this study might bring up a strategy for exploring potential application of PPDO material in orthopedic fixation, tissue filling, and engineered scaffolds.
✓ 已验证
DOI
高影响因子
Biomedical Materials
·
2025
·Vol. 20
·期 2
·025031
·
IF 3.7
Yifan Xv,Li Xu,Dandan Wei,Yinghua Tao,Tianzhu Zhang,Zhenling Ji
This study aims to employ poly-L-lactic acid (PLLA) and poly(p-dioxanone) (PPDO), loaded with naringin (NAR) to fabricate a functionalized degradable mesh which can promote abdominal wall hernia (AWH) repair. Three meshes named PPDO, PLLA/PPDO, and PLLA/PPDO/NAR were fabricated by electrospinning. The physical and chemical properties of the meshes were evaluated from the aspects of morphology, wettability, chemical composition, mechanical properties, and in vitro degradation. Then, the meshes were implanted into rats to evaluate their repair effects on abdominal wall defect models. The mechanical properties of PLLA/PPDO/NAR mesh were superior to the other two meshes, with a fixed tensile strength of 36.47 ± 2.40 N cm−1 and an elongation at break of 287.98% ± 51.67%, which adequately met the mechanical strength required for the human abdominal wall. The core–shell structure effectively delayed the degradation of PLLA/PPDO as well as PLLA/PPDO/NAR mesh, and drug release of PLLA/PPDO/NAR mesh. On the 7th, 14th, and 28th day after implantation, more neovascularization and tissue formation were observed in the PLLA/PPDO/NAR group and the newborn collagen was arranged in a regular and neat manner compared to the other two groups. The immunohistochemical results showed that the PLLA/PPDO/NAR mesh promoted abdominal wall repair by inhibiting the expression of matrix metalloproteinase2 as well as interleukin-6, and increasing the expression of vascular endothelial growth factor. The PLLA/PPDO/NAR mesh is promising for application in AWH repair.
研究领域:
生物医学工程
·
材料科学
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2022
·Vol. 12
·期 1
·1-10
·
IF 4.996
Ren Tongyan,Feng Chengmin,Dong Jun,Zhu Hong,Wang Bing
Implant-associated infections limit the clinical application of implants therapy; hence, exploiting strategies to prevent biomaterial-associated infections has become important. Therefore, in this study, a series of poly (p-dioxanone) (PPDO)-coated Ag loading TiO 2 nanoparticles (Ag@TiO 2 -PPDO) was synthesized to be applied as bacteriostatic coating materials that could be easily dispersed in organic solvent and coated onto implantable devices via temperate methods such as electrospraying. The lattice parameters of TiO 2 were a = 0.504 nm, b = c = 1.05 nm, alpha = beta = gamma = 90 degree and the size of crystallite was about 13 nm, indicating that part of Ag has been embedded into crystal defects of TiO 2 . Both XRD and TEM determinations indicated the successful grating of PPDO on the surface of Ag@TiO 2 . Among Ag@TiO 2 nanoparticles with various Ag loading quantities, 12% Ag@TiO 2 nanoparticles exhibited relatively higher grafting efficiency and Ag contents on the surface of grafted composites. In addition, 12% Ag@TiO 2 -PPDO exhibited the best bacteriostatic effect in vitro owing to its higher grafted efficiency and relatively short length of PPDO segments. Subsequently, Ag@TiO 2 -PPDO was coated on the surface of a poly lactic-co-glycolic acid (PLGA) electrospun membrane via the electrospraying method. Finally, the in vivo bacteriostatic effect of 12% Ag@TiO 2 -PPDO coating was verified by implanting 12% Ag@TiO 2 -PPDO-coated PLGA membrane into a rat subcutaneously combined with an injection of Staphylococcus aureus at implanting sites.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Yutong Zhang,Guoquan Yang,Jieling Zhang
Tendon injuries are common in table tennis and remain difficult to repair because of oxidative stress and limited regenerative capacity. This study developed an electrospun PPDO-COL-I/ x %CeMnBG fiber membrane with potential applications in tendon repair. The membranes exhibited uniform, bead-free morphology, good flexibility, a tensile strength of 5.89 MPa, and an elongation at break of 80%. All groups maintained cell viability above 80% over 5 days, while PPDO-COL-I/1.5%CeMnBG showed the best cell performance, with 110% proliferation on day 5. This group also displayed excellent ROS-scavenging activity, achieving 60% DPPH, 40% SOD, and 60% ABTS clearance, together with reduced intracellular ROS and enhanced L929 migration. These results indicate that PPDO-COL-I/1.5%CeMnBG is a potential candidate for tendon regeneration by integrating structural support, bioactive ion release, and antioxidant protection.
✓ 已验证
DOI
高影响因子
Advanced Fiber Materials
·
2023
·Vol. 5
·期 2
·632-649
·
IF 16.1
Wang Lu,Ma Jingyi,Guo Tao,Zhang Fenghua,Dong Aimeng,Zhang Shiqi,Liu Yanju,Yuan Huiping,Leng Jinsong
Micro- and nano-fibers of shape memory polymers (SMP) offer multiple advantages like high specific surface area, porosity, and intelligence, and are suitable for biomedical applications. In this study, biodegradable poly (p-dioxanone) (PPDO) materials were incorporated to improve the brittleness of shape memory polylactic acid (PLA), and plasticizers were used to reduce the transition temperature of SMP composites such that their transitions could be induced close to body temperature. Furthermore, an electrostatic spinning technology was applied to prepare SMP fibers with wrinkled structures and regulate their microstructures and morphologies such that the intelligent transition of wrinkled and smooth morphologies can be achieved on the fiber surface. The application of this controllable-morphology fiber membrane in intelligent controlled drug release and scar inhibition after Ahmed Glaucoma Valve (AGV) implantation was also studied. The drug release from the stretched and deformed drug-loaded fiber membranes was faster than those from membranes with the original shape. This membrane with micro- and nano-fibers had good anti-scarring effects that improved after drug loading. The achievement of intelligent controlled drug release and the evident anti-scarring effects of the membrane broaden the application of SMP fibers in the biomedical field. Graphical Abstract
研究领域:
生物医学工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Junqin Mao,Yutong Zhang,Qiuyu Zeng,Heng Zheng,Guoyu Lv
Cranial periosteum defects are frequently accompanied by cerebrospinal fluid (CSF) leakage and insufficient regenerative capacity, posing significant clinical challenges. In this study, a Janus nano-bioactive glass (nBG)-loaded PPDO/PCL bilayer electrospun fibrous membrane was designed to simultaneously achieve directional fluid transport and osteogenic regeneration. The asymmetric hydrophilic/hydrophobic architecture enabled unidirectional liquid management, with the hydrophobic layer exhibiting a water contact angle of 145° and the hydrophilic layer showing rapid wetting within 0.8 s. The membrane demonstrated suitable mechanical flexibility, with a tensile strength of 3–4 MPa, meeting periosteal repair requirements. In vitro assays revealed excellent cytocompatibility, with cell viability exceeding 100% over 5 days. Notably, the PPDO/BG-PCL group promoted cell proliferation above 110% on days 3 and 5 and showed negligible hemolysis. nBG enhanced osteogenic differentiation, as evidenced by increased ALP activity at 7 and 14 days and dense calcium nodule formation at 28 days. Moreover, apatite-like hydroxyapatite uniformly covered the fiber surface after 28 days of mineralization. Collectively, this Janus PPDO/BG-PCL membrane integrates effective CSF leakage prevention with sustained bioactive stimulation, representing a promising scaffold for cranial periosteum repair.
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 30
·40554-40565
·
IF 7.8
Yan Lan-Xi,Zhang Jie,Chen Xiao-Hu,Cao Yu-Tao,Zhao Qing,Wu Gang,Chen Si-Chong,Wang Yu-Zhong
Tissue patches have gained widespread attention for their ability to rapidly and effectively close tissue wounds. Nevertheless, maintaining robust adhesive strength under physiological conditions remains a significant challenge for current tissue adhesion materials. Herein, a tissue patch material based on a poly( p -dioxanone)- co -poly(ethylene glycol) (PPDO- co -PEG) copolymer is reported. This copolymer is engineered to exhibit a rigid-to-flexible transition property, with N -hydroxysuccinimide (NHS) groups grafted onto its backbone as adhesive functional moieties. The semi-crystalline structure of the PPDO segments enhances cohesive strength, while PEG segments provide segmental mobility under physiological conditions, enabling NHS to penetrate irregular tissue interfaces and react with surface primary amine groups. Therefore, the patch exhibits excellent tissue adhesion performance, with dry and wet adhesive strength of 2.59 MPa and 189.6 kPa, respectively. Furthermore, the patch has the potential for multifunctional applications, such as effectively sealing wounds in multiple organs with outstanding pressure-resistant stability (326 mmHg), while also offering rapid hemostasis and accelerated tissue healing. In summary, this study presents a feasible design strategy for flexible, high-adhesion tissue patches, which show promising potential for clinical applications in wound management and tissue repair.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）