ADVANCED FUNCTIONAL MATERIALS
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2021
·Vol. 31
·期 47
·2105383
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IF 18.808
Lijun Kuang,Jinghuan Huang,Yutong Liu,Xiaolin Li,Yuan Yuan,Changsheng Liu
Effective treatments to overcome osteoblast/osteoclast imbalance are the key to achieving desirable bone regeneration for osteoporosis patients. When used for local bone repair, parathyroid hormone (PTH) often leads to either excessive osteoclasts under continuous exposure or insufficient osteoclasts with pulsatile release of PTH. Herein, an injectable multifunctional in situ-generated calcium phosphate nanoparticle (ICPN)-coordinated poly(dimethylaminoethyl methacrylate-co-2-hydroxyethyl methacrylate) (DHCP) hydrogel loaded with PTH for near-infrared (NIR)-stimulated release is developed to achieve bone regeneration in an ovariectomized (OVX) model. Photothermal-responsive poly(N-acryloyl glycinamide-co-acrylamide) PNAm-indocyanine green ICG-PTH microspheres (PIP MSs) endow a dual-mode release system with a sustained release at low concentrations, a pulse release of PTH, and in situ pore formation properties. The PIP MS-encapsulated DHCP hydrogel (DHCP-10PIP/d) is injected into the bone defects of OVX rats. Under NIR irradiation, the localized photothermal effects trigger on-demand PTH release and in situ micropores formation through the gel–sol transition of PIP MSs, and the repeated treatment is harmless to the bioactivity of PTH. This platform can enhance osteoblast and osteoclast activity at the same time both in vitro and in vivo and repair the cranial defects of OVX rats successfully. Overall, this work provides a promising strategy for PTH delivery to repair osteoporotic bone defects.
研究领域:
生物医学工程
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骨科
·
药物递送系统
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Xuemei Liu,Yuan Wang,Tian C. Zhang,Gang Xiang,Xinlong Wang,Shaojun Yuan
Arsenic pollution has drawn wide attention, owing to its severe carcinogenicity, strong poisonousness, and high mobility in groundwater. Herein, a magnetic heterojunction nanocomposite of TiO2/polythiophene/γ-Fe2O3 (TiO2/PTh/γ-Fe2O3) was fabricated by one-pot oxidation polymerization as a novel photocatalyst for removing trace As(III) from aqueous solution by a visible-light-driven photocatalytic oxidation–adsorption coupling process. The nanocomposite showed excellent stability to adsorb As(III) in a low-pH region (2–6). Under dark conditions, approximately 46.5% of As(III) was adsorbed by the as-synthesized nanocomposite, and the kinetic data indicated the dominating chemical adsorption. However, under visible light illumination, more than 99.1% of As(III) was transformed into As(V) and simultaneously 90.1% of produced As(V) was adsorbed by the nanocomposite. Furthermore, the photogenerated holes (h+) and superoxide free radicals (•O2–) were the main reactive substances on the TiO2/PTh/γ-Fe2O3 nanoparticle for visible-light-driven photocatalytic oxidation of As(III). The novel magnetic TiO2/PTh/γ-Fe2O3 heterojunction nanocomposite may have potential application for arsenic removal in the aquatic environment.
研究领域:
环境科学
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材料科学
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高影响因子
OPTICAL MATERIALS
·
2022
·
IF 3.754
Yundong Zeng,Yunlan Xu,Dengjie Zhong,Jiaxin Mou,Haoyang Yao,Nianbing Zhong
The development of photocatalytic fuel cell (PFC) with visible-light response is usually limited by the low efficiency of electron-hole separation in photoanode . In this work, 20%-PTh/Ag 3 PO 4 /BiOI/Ti photoanode was prepared for the first time to construct a PFC with Cu 2 O/Cu cathode to degrade rhodamine B. With visible-light stimulation, the rhodamine B degradation rate, maximum photocurrent density and maximum power density of the PFC were respectively 96.33% (2 h), 0.39 mA cm −2 and 82.20 μW cm −2 . The main active species in the PFC were proved by quenching experiments to be h + , ∙OH and ∙O − 2 . The satisfactory performance of the PFC was due to that a double Z-scheme heterojunction was formed in the photocatalyst of 20%-PTh/Ag 3 PO 4 /BiOI/Ti photoanode, which made the photogenerated electrons of Ag 3 PO 4 and BiOI directly combine with the photogenerated holes of PTh , so that the photogenerated holes of Ag 3 PO 4 and BiOI and the photogenerated electrons of PTh directly or indirectly participated in the degradation reaction of RhB. In this way, the separation efficiency of electron-hole pairs in the photoanode was improved, and the performance of the PFC was significantly enhanced.
研究领域:
环境科学
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材料科学
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Jinxing Hou,Guodong Dai,Jiuwu Wang,Xian Sun,Yue Situ,Hong Huang
A novel ternary polythiophene/Ag/protonated g-C 3 N 4 nanosheets (PTh/Ag/pCN) nanocomposite was constructed by electrostatic self-assembly strategy. The as-prepared 5% PTh/Ag/pCN exhibits excellent visible light photocatalytic performance toward methylene orange (MO), which is 6 and 3.7 times higher than pCN and PTh, respectively. The result was dominantly ascribed to the forming of Z-scheme heterojunction due to the synergetic effects of pCN, Ag and PTh, which is conductive to the separation of photogenerated charges. Meanwhile, the radical trapping experiments and ESR techniques proved that the photogenerated holes and superoxide radicals are vital reactive substances. This study provides a powerful approach to enhance catalytic activity of conjugated polymer photocatalyst .
研究领域:
材料科学
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环境科学
·
光催化
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DOI
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Ya Ren,Weiqing Kong,Yihao Liu,Xue Yang,Xiang Xu,Lei Qiang,Xuelian Mi,Changru Zhang,Haoyi Niu,Chengwei Wang,Jinwu Wang
Bone defect repair remains a major clinical challenge that requires the construction of scaffolds that can regulate bone homeostasis. In this study, a photo-cured mesoporous bioactive glass (PMBG) precursor is developed as a tricalcium phosphate (TCP) agglomerant to obtain a double-phase PMBG/TCP scaffold via 3D printing. The scaffold exhibits multi-scale porous structures and large surface areas, making it a suitable carrier for the loading of parathyroid hormone (PTH) (1-34), which is used for the treatment of osteoporosis. In vitro and in vivo results demonstrate that PMBG/TCP scaffolds coordinated with PTH (1-34) can regulate bone homeostasis in a bidirectional manner to facilitate bone formation and inhibit bone resorption. Furthermore, bidirectional regulation of bone homeostasis by PTH (1-34) is achieved by inhibiting fibrogenic activation protein (FAP). Thus, PMBG/TCP scaffolds coordinated with PTH (1-34) are viable materials with considerable potential for application in the field of bone regeneration and provide an excellent solution for the design and development of clinical materials.
研究领域:
生物医学工程
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材料科学
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再生医学
·
骨科
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DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2024
·
IF 7.6
Renxin Chen,Junwu Wang,Lei Chen,Zouwei Li,Qinyu Feng,Fangqi Chen,Zhuowen Hao,Tianhong Chen,Guang Shi,Qi Zhang,Yi Wang,Tao Ding,Jingfeng Li
Despite the rapid development of the application of tissue engineering techniques in regenerative bone repair, the repair of severe pathologic bone defects, represented by osteoporotic bone defects, is still a huge challenge. Recent studies have identified local delivery of parathyroid hormone relative peptides (PTHrPs) as a novel pathway for bone repair as well, but how to load and locally release PTHrPs for good bone repair is a major obstacle. Here, a biopolymer of PLGA-PLL loaded with PTHrP1 is electrospunned into nanofiber membranes for guided bone regeneration. In vitro experiments show that PLGA-PLL synergized with PTHrP1 significantly promote osteogenic differentiation and angiogenesis, providing a favorable bone regeneration microenvironment. In vivo experiments show that the membrane recruits endogenous stem cells and promotes their ectopic osteogenic differentiation in an osteoporotic environment. Furthermore, the membrane can promote osteogenic differentiation and angiogenesis in situ and improve the local osteoporotic microenvironment, ultimately promoting the repair of bone defects. Therefore, present study provides a promising strategy for local delivery of PTH, which opens a new pathway for the treatment of osteoporotic bone defects.
研究领域:
组织工程
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再生医学
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生物材料
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骨修复
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DOI
高影响因子
EUROPEAN POLYMER JOURNAL
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2026
·
IF 6.8
Jie Song,Youming Chang,Yu Zhang,Lijun Chen,Lei Li,Yidan Li
Aiming at the problems of limited conductivity and poor stability of traditional ionic hydrogels, this study prepared polythiophene composite (PTh@Fe-BDA) as a conductive filler, and then designed poly(vinyl alcohol) (PVA) network, sodium poly(acrylic acid) (PAANa), and poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) (PDMC) polyelectrolyte network to construct dual network (DN) gels by introducing conductive fillers into the polymer matrix. When PTh@Fe-BDA was added in the amount of 0.9 g, the tensile strength of the conductive hydrogel was 0.825 MPa, the toughness was 0.0039 MJ/m 3 , and the electrical conductivity was 1155.556 mS/m. The hydrogel exhibited good adhesion and recovery after cycling tests. PVA/PAANa/PDMC/PTh@Fe-BDA conductive hydrogel strain sensing can respond to mechanical stimuli and generate accurate, stable and recoverable electrical signals, and can be used as a flexible wearable device for multiple monitoring strains and subtle movements in different body parts, and can also be used as a capacitive pen to fluently write and draw on the screen of a cell phone or tablet computer. This new multifunctional conductive hydrogel has a wide range of application prospects in electronic skin, motion monitoring and human–computer interaction.
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高影响因子
Analytical Methods
·
2026
·
IF 3
Jiajia Wang,Chun Kan,Demeng Qian,Mingping Gao,Ayang Zhou,Bao-Kang Jin
CA-125, as a tumor marker for ovarian cancer, plays an importance role for rapid and sensitive detection in early diagnosis. Herein, a label-free electrochemical immunosensor based on COF/PTh/MB nanocomposite was constructed for the detection of CA-125.The TAPB-DMTP-COF material, with its large surface area and stable porous framework, was used as the substrate. However, its poor conductivity hindered electron transfer. To address this, conductive polymer PTh was combined with the COF to enhance the composite's conductivity. Meanwhile, MB was used as a signal probe, and differential pulse voltammetry (DPV) was adopted to measure the electrochemical signal. Under optimized experimental conditions, the proposed immunosensor exhibited excellent performance for the CA-125 detection, with a detection range of 1 mU/mL-10000 mU/mL, and a low detection limit of 0.34 mU/mL (S/N = 3), providing a potential platform for clinical application.
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高影响因子
IEEE SENSORS JOURNAL
·
2025
·
IF 4.5
Yong Tao,Shuang Cao,Jianbo Wu,Jiamei Wang,Yifan Yin,Qian Hu,Changan Yang,Binbin Zhou,Liang Chen
A novel ternary nanocomposite of zinc oxide, graphene oxide, and polythiophene (ZnO/GO/PTH) was synthesized via a sonochemical method for ultrasensitive electrochemical detection of ciprofloxacin (CIP) in environmental waters. Comprehensive characterization using XRD, FT-IR, BET (surface area: 28.20 m²/g), FE-SEM/HR-TEM (average particle size: 3.42 nm), and EDS confirmed successful component integration with enhanced interfacial synergy. The ZnO/GO/PTH-modified electrode demonstrated 6.4-fold higher electrocatalytic activity toward CIP oxidation compared to bare GCE, attributed to synergistic π-π stacking interactions, Zn–S coordination, and charge-transfer enhancement. The optimized sensor exhibited outstanding analytical performance: (1) a broad linear range (0.015–6 μM, R² = 0.998), (2) high sensitivity (0.075 μA·μM⁻¹·cm⁻²), and (3) ultralow detection limit (LOD: 0.008 μmol/L, S/N = 3). Remarkably, the sensor retained 95.6% of its initial response after 25 days of storage and showed minimal signal variation (<3.0%) against 20–50-fold excess interferents (Ca²⁺, ofloxacin, etc.). Validated in real water samples (river, lake, tap water), the sensor achieved recoveries of 90.3–102.5% (RSD ≤ 5.7%, n = 5), demonstrating reliability for monitoring environmentally relevant CIP concentrations. This work provides a cost-effective and robust platform for on-site antibiotic surveillance in aquatic ecosystems.
研究领域:
环境科学
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纳米技术
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电化学
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分析化学
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水质监测
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传感器技术
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DOI
高影响因子
MATERIALS & DESIGN
·
2026
·
IF 8.2
Xiaofeng Chen,Zhengzhe Han,Xin Qi,Gaofeng Huang,Junjie Zheng,Yongfeng Li,Shiqiang Zhuo,Jinying Wang,Lin Huang,Qinci Xie,Xiaolin Li
A composite scaffold containing PTH- and proanthocyanidin (PC)-loaded microspheres (GTP@PTH) was successfully developed. • The GTP@PTH retains mechanical stability and provides sustained release of PTH. • The scaffold promotes M2 macrophage polarization via Nrf2/HO-1 activation and NF-κB inhibition. • The GTP@PTH enhances osteogenesis, angiogenesis, and inhibits osteoclast activity in vivo . The treatment of osseous deficiencies in osteoporotic patients continues to pose significant clinical difficulties, requiring scaffolds that can simultaneously modulate the regenerative immune microenvironment and restore bone homeostasis. Here, we fabricated porous microspheres capable of the sustained release of the immunomodulator proanthocyanidin (PC) and the bone‑anabolic regulator PTH(1‑34). These microspheres were then integrated into a 3D‑printed organic–inorganic composite scaffold that exhibited high compressive strength and modulus. The scaffold’s interconnected porosity supported tissue in‑growth, while its high modulus and inorganic salt composition promoted osteogenic differentiation of stem cells. In parallel, surface‑grafted alendronate (ALN) regulated osteoblast/osteoclast activity and chelated calcium ions on the bone surface to form stable interfacial structures. Both in vitro and in vivo studies indicate that the GTP@PTH scaffold, leveraging the combined actions of PC and PTH (1–34), modulates the immune microenvironment and skeletal homeostasis to support bone regeneration. This system restrains M1 macrophage polarization, promotes an M2 phenotype, and limits osteoclast over-differentiation, thus enhancing osteogenic activity. Such a multifunctional platform shows considerable promise for repairing bone defects under osteoporotic conditions, offering a viable approach for developing clinically applicable biomaterial solutions. Download: Download high-res image (124KB) Download: Download full-size image
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高影响因子
Polymers
·
2019
·Vol. 11
·期 4
·599
·
IF 3.164
Chun-Na Yan,Qian Liu,Lin Xu,Li-Ping Bai,Li-Ping Wang,Guang Li
Well-defined amphiphilic diblock copolymer poly (methyl methacrylate)-b-poly (N-isopropylacrylamide) grafted hollow spheres (HS-g-PMMA-b-PNIPAM) hybrid materials were synthesized via metal-free surface-initiated atom transfer radical polymerization (SI-ATRP). The ATRP initiators α-Bromoisobutyryl bromide (BIBB) were attached onto hollow sphere surfaces through esterification of acyl bromide groups and hydroxyl groups. The synthetic ATRP initiators (HS-Br) were further used for the metal-free SI-ATRP of methyl methacrylate (MMA) and N-isopropyl acrylamide (NIPAM) using 10-phenylphenothiazine (PTH) as the photocatalyst. The molecular weight of the polymers, structure, morphology, and thermal stability of the hybrid materials were characterized via gel permeation chromatography (GPC), X-ray photoelectron spectroscopy (XPS),1H-nuclear magnetic resonance spectroscopy (1H NMR), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA), respectively. The results indicated that the ATRP initiator had been immobilized onto HS surfaces successfully followed by metal-free SI-ATRP of MMA and NIPAM, the Br atom had located at the end of the main PMMA polymer chain, and the polymerization process possessed the characteristic of controlled/“living” polymerization. The thermal stability of the hybrid materials was increased significantly compared to the pure PMMA and PNIPAM.Keywords:hollow spheres;metal-free ATRP;SI-ATRP;10-phenylphenothiazine (PTH);thermal stability
研究领域:
材料科学
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高分子化学
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DOI
PubMed
高影响因子
Journal of Biomedical Nanotechnology
·
2018
·Vol. 14
·期 10
·1688-1694
·
IF 5.068
Lai Yuxuan,Deng Yan,Yang Gaojian,Li Song,Zhang Chuanxiang,Liu Xueying
A novel molecular imprinted polymer (MIP) electrochemical sensor was successfully fabricated for sensitive detection of carcinomaembryonic antigen (CEA). We used CEA as template, dopamine (DA) as imprinted monomers. Through controlling electropolymerization, a "PDA-CEA"complex was achieved.
After elution, the specific cavities adsorbed the target molecules. In addition, polythionine (PTh) and AuNPs were applied as the electrode modifying materials to enhance electron transfer rate and improve detection signal. Using differential pulse voltammetry (DPV) detection, the peak current
decreased with the increase in concentration of CEA, and the linear response range of the MIP sensor was from 0.001 ng/mL to 1000 ng/mL with the detection limit as low as 0.2589 pg/mL. The MIP sensor had a low sample consumption, good stability, and high sensitivity, and could become a new
promising method for the detection of CEA. Furthermore, this MIP sensor was demonstrated in testing CEA in human serum sample with satisfactory results.
研究领域:
分析化学
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生物传感器
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电化学
·
癌症诊断
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）