INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Bin Li,Xiaojuan Li,Shuying Li,Chen Chen,Ting Xiao,Yuehong Xu
Psoriasis is a chronic and incurable inflammatory skin disease usually requiring long-term disease management. Natural phytochemical resveratrol (RES) has been known for high efficiency and low toxicity, exhibiting good anti-psoriasis potential. However, its biological activity is limited by poor solubility, chemical instability, and insufficient skin retention. Herein, we developed an adhesive eutectogel loaded with RES constructed through electrostatic and hydrogen bonding cross-linking between cyclodextrin-levulinic acid supramolecular deep eutectic solvent (DES) and chitosan (CS). A series of characterizations combined with molecular dynamics simulations demonstrated that such DES not only significantly increased the solubility and stability of RES, but also acted as the cross-linker and plasticizer in eutectogel preparation. When applied to the skin surface, the eutectogel formed a soft film in situ that established tight contact with the skin, thereby enhancing RES sustained penetration into the skin. In an imiquimod-induced psoriasis-like mice model, the eutectogel effectively alleviated psoriasis symptoms, inhibited the excessive proliferation of keratinocytes, and regulated the expression of IL-23/IL-17 axis-related factors, whose therapeutic effect was better than that of commercially available calcipotriol ointment. Overall, The DES-strengthened eutectogel offers a promising topical drug delivery platform for psoriasis treatment and expands the applications of green polysaccharide medical materials.
研究领域:
药剂学
·
皮肤科
·
生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2025
·
IF 5.7
Dan-pu Zhao,Zhi-kun Peng,Shuai Wei,Qing-Qing Pang,Qiao-yun Liu,Zhong-yi Liu
Heterogeneous interfaces are an effective strategy to modulate interfacial properties and enhance catalytic functionality. However, their dynamic evolution under reaction conditions remains elusive, hindering rational catalyst design. Herein, we report a ReS2-CoO/CoS2 heterostructure to investigate its structural transformation under electrocatalytic water splitting conditions, as well as to modulate its activity and stability. Electrochemical measurements reveal exceptional bifunctional catalytic activity, with overpotentials of 25 mV for HER (at 10 mA·cm⁻²) and 241 mV for OER (at 50 mA·cm⁻²). The synergistic interfacial interaction substantially enhances the kinetic processes. The integrated interface between CoO and CoS2 on ReS2 not only ensures intimate electronic coupling but also facilitates abundant surface defect formation, as confirmed by FTIR, XPS, and EPR analyses. In-situ Raman spectroscopy demonstrates structural robustness during HER, whereas a significant surface reconstruction occurs during the OER, in which the initial CoO/CoS2 phase transforms into CoO/CoOOH, serving as the new active species. The catalyst achieves efficient overall water splitting performance (1.43 V at 10 mA‧cm⁻2) with sustained performance. These findings offer valuable insights into interfacial engineering strategies for the rational design of advanced electrocatalysts.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Liying Huang,Lixian Zhang,Jun Su,Zhitian Shi,Min Zhang,Tingting Yan
Inflammation, trauma, or diabetes can cause alveolar bone to become soft, slack, and bone-deficient. If left untreated, this can eventually result in resorption and constriction of the alveolar bone. The inability of the alveolar bone to heal itself clinically presents a challenge for future dental implants and other procedures. In order to overcome this difficulty, we created an injectable, light-curable hydrogel composite (Res@KGMMA/α-CSH/HMSN) that contains α-calcium sulfate hemihydrate (α-CSH) and hollow mesoporous silica nanoparticles (HMSN) loaded with resveratrol (Res) in a methacrylated konjac glucomannan (KGMMA) matrix. This composite effectively conforms to irregular bone defects, gels quickly when exposed to blue light, and allows for sustained drug release while reducing the risk of leakage. Significant antibacterial activity against Staphylococcus aureus and Escherichia coli was shown in vitro tests, along with increased human periodontal ligament stem cell proliferation. By the eighth week, micro-CT and histological analyses in a rabbit alveolar bone defect model showed significant new bone formation and upregulated expression of osteogenic markers (OPG, RUNX2, COL I, OPN, OCN). These results highlight the composite's exceptional osteogenic potential, biocompatibility, and clinical promise for alveolar bone regeneration.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Orthopaedic Surgery and Research
·
2026
·
IF 2.8
Zhu Zhonglian,Chang Jiankang,Gao Xubin,Wang Zhaodong,Duan Keyou,Guan Jianzhong
Excessive inflammation driven by macrophage phenotype imbalance is a key pathological barrier hindering neural repair after spinal cord injury (SCI). Here, methacryloyl gelatin hydrogel (GelMA) loaded with natural anti-inflammatory agent resveratrol (Res) was designed and synthesized. Scanning electron microscopy (SEM), x-ray diffraction (XRD), fourier-transform infrared spectroscopy (FT-IR), Ultraviolet (UV) and rheological characterization confirmed that Res-loaded GelMA hydrogel (Res@GelMA) was successfully synthesized. High-Performance Liquid Chromatography (HPLC) analysis demonstrated sustained Res release. CCK8 and cell adhesion experiments confirmed that Res@GelMA treatment did not affect the cell function of RAW264.7 and had good cell compatibility. Flow cytometry, Enzyme-Linked Immunosorbent Assay (ELISA) and western blot assays revealed that Res@GelMA treatment promoted RAW264.7 to M2 polarization, while reducing the levels of inflammatory factors (IL-1β, IL-6, TNF-α) and down-regulating the expression of IL-1R1/MyD88/TNFR1 inflammatory signaling proteins. Transcriptome sequencing combined with functional screening identified C-type lectin receptor Clec7a as a key target gene regulated by Res@GelMA. Importantly, knockdown of Clec7a and Res@GelMA were both anti-inflammatory, promoted M2 polarization, and blocked the activation of the TLR2/TLR4-p38 MAPK signaling axis. In the SCI mouse model, local implantation of Res@GelMA significantly improved tissue pathological damage and enhanced motor function recovery compared with free Res or blank GelMA. In addition, Res@GelMA achieved systemic anti-inflammation by downregulating the Clec7a-TLR-p38 pathway in the injured area and promoting M2 polarization. This study developed an anti-inflammatory hydrogel material that can regulate the phenotype of macrophages, laying a theoretical and technical foundation for the development of neural repair strategies targeting the inflammatory microenvironment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2023
·
IF 4.1
Xiaoqian Xu,Qiang Cao,Jin Yuan,Ping Tong,Xin Li,Anshu Yang,Zhihua Wu,Xiaohua Liu,Hongbing Chen,Jinyan Gao
BACKGROUND The interaction between food allergens and plant polyphenols has become a safe and effective management strategy to prevent food allergies. Ovalbumin (OVA) is the most abundant allergen in egg whites. Resveratrol (RES) is a plant polyphenol that is abundant in red grapes, berries, and peanuts, and has an anti-allergic effect on allergy-related immune cells. However, there is little information about the effect of RES on the allergenicity of OVA. In this study, the effect of RES on the allergenicity of OVA was investigated. RESULTS Molecular docking and spectroscopic studies indicated that the addition of RES changed the structure of OVA. The digestion and transfer rate of OVA–RES were effectively improved with an in vitro gastrointestinal digestion model and Caco-2 cell model, especially when the molar ratio of OVA–RES was 1:20. Meanwhile, the KU812 cell degranulation assay proved that the potential allergenicity was remarkably decreased while the molar ratios of OVA–RES were increased to 1:20. Furthermore, hydrogen bonds and van der Waals forces were the dominating forces to stabilize the OVA–RES complexes. CONCLUSION All the findings demonstrated that the potential allergenicity of OVA was reduced when interacting with RES, and RES can be a potential food material for preparing a hypoallergenic protein, especially for egg allergy. © 2023 Society of Chemical Industry.
研究领域:
食品科学
·
过敏研究
·
分子生物学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2013
·
IF 5.371
Hongjun Gao,Jie Xiong,Tangjian Cheng,Jinjian Liu,Liping Chu,Jianfeng Liu,Rujiang Ma,Linqi Shi
The miserable targeting performance of nanocarriers for cancer therapy arises largely from the rapid clearance from blood circulation and the major accumulation in the organs of the reticuloendothelial system (RES), leading to inefficient enhanced permeability and retention (EPR) effect after intravenous injection (i.v.). Herein, we reported an efficient method to prolong the blood circulation of nanoparticles and decrease their deposition in liver and spleen. In this work, we fabricated a series of mixed shell micelles (MSMs) with approximately the same size, charge and core composition but with varied hydrophilic/hydrophobic ratios in the shell through spontaneously self-assembly of block copolymers poly(ethylene glycol)-block-poly(l-lysine) (PEG-b-PLys) and poly(N-isopropylacrylamide)-block-poly(aspartic acid) (PNIPAM-b-PAsp) in aqueous medium. The effect of the surface heterogeneity on the in vivo biodistribution was systematically investigated through in vivo tracking of the 125I-labeled MSMs determined by Gamma counter. Compared with single PEGylated micelles, some MSMs were proved to be significantly efficient with more than 3 times lower accumulation in liver and spleen and about 6 times higher concentration in blood at 1 h after i.v.. The results provide us a novel strategy for future development of long-circulating nanocarriers for efficient cancer therapy.
研究领域:
药学
·
纳米技术
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2015
·Vol. 15
·期 6
·4111-4118
·
IF 1.556
Song Lina,Zang Fengchao,Song Mengjie,Chen Gong,Zhang Yu,Gu. Ning
In this strategy, a magnetic fluid of the Fe3O4 nanomicelles was synthesized with amphiphilic PEGylated phospholipid as surfactant and soybean oil as stabilizer under simple mechanical stirring and subsequent ultrasonication. Transmission electron microscope (TEM)
measurement indicated that the sample is monodisperse spherical Fe3O4 nanoparticles with internal core size of 9 nm and external nanomicelle shell thickness of 1.5 nm. The final hydrodynamic size of the sample is 19.5 nm and its zeta potential is −38.5 mV, suggesting
good stability of the magnetic nanomicelles in water. To assess the ability of magnetic nanomicelles to escape reticuloendothelial system (RES) uptake, in vitro cell phagocytosis experiments were conducted using murine macrophages (RAW264.7). The results indicated that the PEGylation
can effectively prevent the uptake of the nanomicelles by the macrophages. Using a mouse model of 4T1 breast cancer, the nanomicelles provided a good magnetic resonance imaging (MRI) capability to sensitively detect tumor by enhanced permeability and retention (EPR) effect. The PEGylated monodisperse
magnetic nanomicelles would become a potential contrast agent for passive targeting diagnosis of tumor by MR imaging.
研究领域:
纳米技术
·
医学成像
·
癌症研究
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-18
·
IF 16.6
Li Zheng,Zhu Yabo,Zeng Haowen,Wang Chong,Xu Chen,Wang Qiang,Wang Huimin,Li Shiyou,Chen Jitang,Xiao Chen,Yang Xiangliang,Li Zifu
Nanomedicine has been developed for cancer therapy over several decades, while rapid clearance from blood circulation by reticuloendothelial system (RES) severely limits nanomedicine antitumour efficacy. We design a series of nanogels with distinctive stiffness and investigate how nanogel mechanical properties could be leveraged to overcome RES. Stiff nanogels are injected preferentially to abrogate uptake capacity of macrophages and temporarily block RES, relying on inhibition of clathrin and prolonged liver retention. Afterwards, soft nanogels deliver doxorubicin (DOX) with excellent efficiency, reflected in high tumour accumulation, deep tumour penetration and outstanding antitumour efficacy. In this work, we combine the advantage of stiff nanogels in RES-blockade with the superiority of soft nanogels in drug delivery leads to the optimum tumour inhibition effect, which is defined as mechano-boosting antitumour strategy. Clinical implications of stiffness-dependent RES-blockade are also confirmed by promoting antitumour efficacy of commercialized nanomedicines, such as Doxil and Abraxane.
研究领域:
药理学
·
纳米技术
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Yuan Gu,Yanjun Cai,Yige Kou,Erzhuo Cheng,Hanjie Bi,Min Hu,Songyao Wu,Yong Jiang,Jingxi Zhang,Qingting Wu,Yunyi Li,Bin Yang
Nanomaterial-based drug delivery systems have demonstrated powerful applications in tumor therapy. PAMAM dendrimers by virtue of multivalent modification and biocompatible components were widely used to construction multifunctional targeted chemotherapeutics. In this report, we present a PAMAM dendrimer-based nano-prodrug delivery system for targeted tumor therapy. The RGDyC-PEG-PAMAM-PBA-Res (RPPPR) nano-prodrug was characterized by 1 H NMR, zetasizer, and TEM, the drug loading and pH-sensitive drug release behaviors were investigated. In vitro cell viability assay revealed that the group treated with the nano-prodrug exhibited lower cell viability compared to the control group as concentration increased, confirming the nano-prodrug’s effectiveness in treating tumors. In vitro studies on cellular uptake of the nano-prodrug demonstrated that RPPPR had a high targeting ability, primarily attributed to the RGD-mediated target effect. Relevant data from our hemolysis assay indicated that the nano-prodrug maintained good blood compatibility within the concentration range of 0.1 to 0.3 mg/mL. In vivo experiments focusing on tumor therapy showed that RPPPR suppressed tumor growth and promoted tumor apoptosis. H&E staining, TUNEL assay, and immunohistochemistry results further validated the enhanced therapeutic effect. Importantly, no toxicity was observed in the vital organs such as the heart, liver, lung, kidneys, or spleen. These results suggest the superior antitumor efficacy of RPPPR compared to Resveratrol alone, and thus may be useful for tumor therapy. It is expected to explore new directions to establish a general strategy with dendritic prodrugs for synergistic tumor targeting therapy.
研究领域:
纳米技术
·
药学
·
癌症治疗
·
药物递送系统
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Nano Today
·
2023
·
IF 17.4
Lu Tan,Menghuan Li,Hang Chen,Yuchen Zhang,Yuan Liu,Maohua Chen,Zhong Luo,Kaiyong Cai,Yan Hu
Severe trauma wound management remains a crucial challenge in the clinics owing to the uncontrollable bleeding and acute inflammatory responses. To achieve rapid hemostasis and reduce local inflammation of large hemorrhagic wounds, we proposed a composite hydrogel dressing through the free radical polymerization of methacrylate gelatin (GelMA), bisphosphonic acid (BP) and cyclodextrin (CD)-modified hyaluronic acid (HA) and loaded with anti-inflammatory drug resveratrol (RES) through supramolecular inclusion. After implantation into bleeding wounds, the hydrogel could electrostatically enrich blood cells and platelets around the wound area to accelerate thrombosis and also increase its own weight to compress local blood vessels for reducing blood loss. Moreover, the cross-linking degree of the HG-CB-based hydrogels could be enhanced in a self-evolving manner through coordination between BP and blood-derived iron ions , leading to increasing biomechanical performance to avoid hydrogel rupture and secondary bleeding. In addition, the hydrogel continuously released RES to increase secretion of anti-inflammation factors, which may stimulate fibroblast migration and accelerate collagen deposition at the wound site. Overall, the HG-CB-based composite hydrogels exhibited excellent rapid hemostatic properties for treating large bleeding wounds and accelerated wound repair via RES-mediated inflammation amelioration, which may provide an approach for managing severe traumatic wounds in the clinics.
研究领域:
生物材料
·
组织工程
·
伤口愈合
·
止血
·
炎症
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）