ACS Omega
·
2022
·
IF 4.132
Hongni Wang,Xiaoqian Li,Fangfang Su,Jinliang Xie,Yangyang Xin,Weirui Zhang,Chen Liu,Dongdong Yao,Yaping Zheng
Despite many important industrial applications, epoxy resin (EP) suffers from high flammability and toxicity emission, extremely hampering their applications. To circumvent the problem, core–shell structured ZIF67@ZIF8 is successfully synthesized and further functionalized with phytic acid (PA) to obtain PA-ZIF67@ZIF8 hybrids. Then, it is used as an efficient flame retardant to reduce the fire risk of EP. The fire test results show a significant reduction in heat and smoke production. Compared with EP, incorporating 5.0 wt % PA-ZIF67@ZIF8 into EP, the peak heat release rate, total heat release, and peak carbon monoxide production are dramatically reduced by 42.2, 33.0, and 41.5%, respectively. Moreover, the EP/PA-ZIF67@ZIF8 composites achieve the UL-94 V-0 rating and the limiting oxygen index increases by 29.3%. These superior fire safety properties are mainly attributed to the excellent dispersion and the catalytic effect of metal oxide and phosphorus-containing compounds. This work provides an efficient strategy for preparing a promising ZIF-based flame retardant for enhancing flame retardancy and smoke toxicity suppression of EP.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Separations
·
2022
·Vol. 9
·期 12
·441
·
IF 3.344
Xiaoman Li,Ruobing Qiao,Xuyang Jiu,Minglei Tian
(+)-catechin is one category of flavonoids in cocoa shell waste and it has been reported to have many health benefits. In order to isolate it from aqueous extracted solution of cocoa shell waste by solid phase extraction (SPE), a series of dual ionic liquids@ZIF8-covered silica were prepared as the sorbents. Regarding the operation conditions of SPE and the characteristic structure of (+)-catechin, ZIF8-covered silica was synthesized to establish a stable and porous substrate, and various dual ionic liquids with multiple properties were immobilized on substrate to obtain a high adsorption capacity. Different adsorption conditions were investigated and the highest adsorption capacity (58.0 mg/g) was obtained on Sil@ZIF8@EIM-EIM at 30 °C during 60.0 min. When the sorbent was applied in the SPE process, 96.0% of the total amount of (+)-catechin from cocoa shell waste can be isolated after several washing and elution steps. The satisfactory recoveries of 97.5–100.2% and RSDs of 1.3–3.2% revealed that the SPE process was accurate and precise. The stability of Sil@ZIF8@EIM-EIM was tested in water and the reusability was tested using repeated adsorption/desorption process. The results revealed that Sil@ZIF8@EIM-EIM as an efficient sorbent can isolate (+)-catechin from cocoa shell waste.Keywords:dual ionic liquid;ZIF8;composited silica;solid phase extraction;(+)-catechin;cocoa shell waste
研究领域:
化学工程
·
食品科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
TRANSITION METAL CHEMISTRY
·
2025
·
IF 1.7
Wang Yuqin,He Lizi,Han Ning,Li Lishuang,Wang Meiyang
It is of great practical significance to explore and prepare cheap, high-performance, and stable catalysts for oxygen reduction reaction (ORR), but it is still in progress at present. Herein, a straightforward evaporation–pyrolysis strategy is designed for the preparation of 3D porous electrocatalysts (denoted as \(\textrm{Fe}-\textrm{Co}-\textrm{NC}\) , which represented carbonization products at °C) made of carbon nanoparticles combined with metallic Fe-Co-doped N-enriched bridged carbon nanotube by carbonization of a pristine ZIF8 as highly efficient and durable ORR electrocatalysts. The obtained Fe–Co–NC structure possesses 3D open porous texture, abundant active sites, desired nitrogen bonding type, and high specific surface area, providing them with excellent ORR activity. The optimal performing \(\textrm{Fe}-\textrm{Co}-\textrm{NC}\) catalyst presents an outstanding ORR performance in terms of a high onset potential ( \(\textrm{E}_{\text{ onset } }\) ) of 0.96 V (vs. RHE) and half-wave potential ( \(\textrm{E}_{1 / 2}\) ) of 0.86 V (vs. RHE), respectively, possible to rival those of the commercially available \(\textrm{Pt} / \textrm{C}\) in an alkaline electrolyte solution. Besides, the \(\textrm{Fe}-\textrm{Co}-\textrm{NC}\) catalyst manifests better stability than those of commercially available \(\textrm{Pt} / \textrm{C}\) , which is of importance for the optimization and characterization of novel electrocatalysts originated from non-precious metals.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Dingkun Liu,Jinbing Chen,Linjuan Gao,Xing Chen,Liujun Lin,Yuan Liu,Xia Wei,Yu Pan,Yinghui Wang,Hui Cheng
Dental implant restoration has become one of the most important treatments for missing teeth. However, peri-implantitis is a common complication of implant restorations, and lack of timely and effective treatment will most likely lead to implant failure. Here, we developed a chitosan-based multifunctional temperature-sensitive hydrogel. Chitosan (CS)/β-glycerophosphate (β-GP) as the body of the hydrogel enabled a gelation transition at physiological temperatures. To enhance functionality, we designed Sim@ZIF8@PDA nanoparticles (SZP), where simvastatin (Sim) was loaded onto the zeolitic imidazolate framework-8 (ZIF8), leveraging its high drug-loading capacity and pH-sensitive release properties. These nanoparticles were further coated with polydopamine (PDA) to enhance photothermal efficiency and stability. The SZP nanoparticles were subsequently integrated with CS/β-GP to form the SZP/CS/β-GP hydrogel. The results showed that under near-infrared light irradiation, PDA exerted a photothermal effect to achieve anti-infection, while the release of simvastatin could promote the differentiation of CD4+ T cells to regulatory T cells (Tregs) to achieve immunoregulation. SZP/CS/β-GP hydrogel attenuated the infection and inflammation at the peri-implantitis lesion. In conclusion, this study provides a new approach for the non-surgical treatment of peri-implantitis.
研究领域:
牙科材料
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纳米医学
·
药剂学
·
再生医学
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免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2016
·
IF 3.926
Xiaohong Yang,Changxia Li,Meiling Qi,Liangti Qu
This work presents the separation performance of graphene-ZIF8 (G-Z) composite material as stationary phase for capillary gas chromatography (GC). The G-Z stationary phase achieved high column efficiency of 5000 plates/m determined by n -dodecane ( k = 1.22) at 120 °C and showed weakly polar nature. Importantly, it exhibited high selectivity and resolving capability for branched alkane isomers and aromatic positional isomers, showing clear advantages over the reported neat graphene and ZIF8. In addition, it attained high resolution for geometric cis -/ trans -isomers. The G-Z column exhibited good column thermal stability up to 300 °C and column repeatability with RSD values of retention times in the range of 0.01–0.19% for intra-day, 0.05–0.88% for inter-day and 0.66–5.6% for between-column, respectively, Moreover, the G-Z column was employed for the determination of minor impurity isomers in real reagent samples, which demonstrates its promising potential in GC applications .
研究领域:
分析化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Lixiao Bi,Shiji Jia,Wenshuang Zhang,Yikun Zhu,Yiwei Gao,Chongbin Wang,Yuanyuan Feng
Inserting metal–organic frameworks into polymer matrix to prepare mixed matrix membranes (MMMs) is a promise strategy for the preparation of organic solvent nanofiltration (OSN) membranes. However, MMMs prepared via traditional physical blending strategy exhibits the disadvantage of uneven dispersion of MOFs particles, resulting in a decrease in organic solvent resistance and membrane performances. In this work, the magnetically responsive nanomaterials (Fe 3 O 4 @ZIF8) were successfully prepared via growing ZIF8 functional layer upon Fe 3 O 4 nanoparticles. Then, the OSN membranes were fabricated via embedding the Fe 3 O 4 @ZIF8 into polymer matrix under a magnetic condition during non-solvent induced phase separation. The magnetically responsive Fe 3 O 4 @ZIF8 particles were compelled to segregate and enrich in membrane surface, optimizing the arrangement of Fe 3 O 4 @ZIF8 within the membrane. This strategic modification significantly improves the porosity and solvent resistance property of membrane. The optimized M−Fe 3 O 4 @ZIF8(0.3)/PAN membrane exhibited an increased permeance of methanol from 40.5 m -2 h −1 bar −1 to 55.5 m -2 h −1 bar −1 compared to the pristine PAN membrane while the retention to Congo Red increased above 99 %. The M−Fe 3 O 4 @ZIF8(0.3)/PAN membrane also possesses excellent permeation of organic solvent and a selectivity (NaCl/Congo Red) of 232, which makes these MMMs promising for salt/dye separation in organic solvent nanofiltration.
研究领域:
材料科学
·
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2019
·
IF 3.553
Xuejia Shi,Jin Xu,Changning Lu,Zhenzhong Wang,Wei Xiao,Linguo Zhao
The magnetic particle Fe 3 O 4 -SiO 2 -NH 2 -Cellu-ZIF8 (FSNCZ8) was used to immobilize the high-temperature resistant GH3 β-glucosidase (Tpebgl3) from the Thermomotoga petrophila DSM 13995. The Tpebgl3 has great potential in the catalytic conversion of pharmaceutically active components. The magnetic carrier (FSNCZ8) which provided stronger adsorption capacity, magnetic and high-temperature stability than the previously discussed Fe 3 O 4 -NH 2 -Cellu-ZIF8 without tetraethyl silicate coated. The properties of FSNCZ8-Tpebgl3 (FSNCZ8-T) were as follows: The optimal temperature and pH were 90 °C and 5.5, respectively; the highest activity of FSNCZ8-T approached 2672 U/g; Fe 2+ enabled immobilized enzyme to increase its relative activity to 194%. The main characteristics of FSNCZ8-T, including thermal stability, pH stability, and glucose tolerance, were greatly enhanced by adding Fe 2+ , which was also superior to free enzymes; moreover, the residual activity of FSNCZ8-T was 74% of the initial activity at the end of 10 repeated cycles.
研究领域:
生物化学
·
酶工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2022
·
IF 5.988
Zhao Ziming,Liu Zhaorong,Hua Yabing,Pan Yuanjie,Yi Ge,Wu Shengyue,He Cong,Zhang Yanzhuo,Yang Yihua
Tumor hypoxic microenvironment can reduce the therapeutic effects of chemotherapy, radiotherapy, photodynamic therapy, immunotherapy, etc. It is also a potential source of tumor recurrence and metastasis. A biomimetic nanosystem based on zeolitic imidazolate framework 8 (ZIF8), which had multifunctions of hypoxia relief, chemotherapy, and photothermal therapy, was established to improve tumor hypoxic microenvironment and overcome the corresponding therapeutic resistance. ZIF8 enveloped with DOX and CuS nanoparticles (DC@ZIF8) was synthesized by a sedimentation method. Red blood cell membrane and catalase (CAT) were coated onto DC@ZIF8 and biomimetic nanosystem (DC@ZIF8-MEMC) was formed. The designed DC@ZIF8-MEMC had a shape of polyhedron with an average particle size around 254 nm. The loading content of DOX, CAT, and CuS was 4.9%, 6.2%, and 2.5%, separately. The release of DOX from DC@ZIF8-MEMC was pH dependent and significantly faster at pH 5 due to the degradation of ZIF8. DC@ZIF8-MEMC exhibited outstanding photothermal conversion properties and excellent antitumor effect in vitro and in vivo. Moreover, the hypoxia relief by CAT was proved to have good sensitization effect on chemo-photothermal combined therapy. DC@ZIF8-MEMC is a prospective nanosystem, which can realize great chemo-photothermal synergistic antitumor effect under the sensitization of CAT. The biomimetic multifunctional nanoplatform provides a potential strategy of chemo-photothermal synergistic antitumor effect under the sensitization of CAT.
研究领域:
纳米技术
·
肿瘤学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 24
·4478
·
IF 5.719
Qingyuan Wang,Zhizheng Zhang,Dehui Qiu,Xuanxiang Mao,Zhaoxi Zhou,Tiansong Xia,Jifu Wei,Qiang Ding,Xiaobo Zhang
Just-in-time evaluation of drug resistance in situ will greatly facilitate the achievement of precision cancer therapy. The rapid elevation of reactive oxygen species (ROS) is the key to chemotherapy. Hence, suppressed ROS production is an important marker for chemotherapy drug resistance. Herein, a NIR-II emission smart nanoprobe ([email protected], consisting of a lanthanide-doped nanoparticle (LnNP) core and metal-organic framework shell (ZIF8)) is constructed for drug delivery and in vivo NIR-II ratiometric imaging of ROS for tumor drug resistance evaluation. The drug-loaded nanoprobes release therapeutic substances for chemotherapy in the acidic tumor tissue. As the level of ROS increases, the LnNPs shows responsively descending fluorescence intensity at 1550 nm excited by 980 nm (F1550, 980Ex), while the fluorescence of the LnNPs at 1060 nm excited by 808 nm (F1060, 808Ex) is stable. Due to the ratiometric F1550, 980Ex/F1060, 808Ex value exhibiting a linear relationship with ROS concentration, NIR-II imaging results of ROS change based on this ratio can be an important basis for determining tumor drug resistance. As the chemotherapy and resistance evaluation are explored continuously in situ, the ratiometric imaging identifies drug resistance successfully within 24 h, which can greatly improve the timeliness of accurate treatment.Keywords:lanthanide doped nanoparticle;ZIF8;NIR-II ratiometric imaging;smart drug delivery system;tumor drug resistance evaluation
研究领域:
癌症治疗
·
纳米技术
·
生物医学工程
·
药学
·
成像技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Meng Chen,Xihui Cheng,Jiwei Li,Na Wang
A multi-use fibrous filter medium composed of an electrospun polyimide (PI) nanofiber layer and a functional zeolitic imidazolate framework-8 (ZIF8) nanofilm layer was successfully fabricated to cope with the complex environmental pollution issues. The nanofilm layer consists of the anti-microbial ZIF8 converted from non-toxic zinc oxide (ZnO) nanocoating on PI fibers. One-step magnetron sputtering is utilized to deposit the ZnO nanocoating for the sake of desired functionality conformally onto the PI nanofibrous membrane without sacrificing its bulk structure and mechanical performance. The as-prepared PI/ZIF8 nanofibrous filter medium showed conspicuous biocidal efficacy and excellent interception ratio against gram-negative Escherichia coli (>99.9%) and gram-positive Staphylococcus aureus (>99.9%) within 20 min contact. Besides, compared with commercial media, the bilayer PI/ZIF8 fibrous medium showed exceptional thermal-wet comfortability due to the high porosity that could realize effective heat and humidity conduction. Moreover, the PI/ZIF8 30 NFM still present a high filtration efficiency of 99.6% towards PM 0.3 even after treated at 300 °C for 1 h. Furthermore, the PI/ZIF8 30 NFM with a fiber basis weight of 1.8 g/m 2 was endowed with a permeate flux of 17,279.2 L/m 2 /h and a high oil/water separation efficiency of > 99.6% because of the hydrophobicity and superoleophilicity. We envision that the antimicrobial, thermal-wet comfort, multi-use fibrous membrane will serve as a core-medium of environmentally-friendly platform for bioprotective equipment against future pathogen threats or oily wastewater treatment .
研究领域:
环境科学
·
材料科学
·
纳米技术
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jinhong Cai,Shuhan Liu,Qiuling Zhong,Yifeng Shang,Zhengrong Chen,Yi Yao,Bo Zhou,Feiying Yin,Jinmin Zhao,Li Zheng
An ideal wound dressing has both efficient antimicrobial and anti-inflammatory properties, as well as the potential to regulate the immune microenvironment for the treatment of chronically infected wounds. Herein, a novel multifunctional hydrogel wound dressing (HPZ8) was developed for wound healing by incorporating polydopamine Zeolite Imidazole Framework 8 (PDA-ZIF8) nanoparticles into a dynamic cross-linked network consisting of hydrazide-modified hyaluronic acid (HA-CDH) and oxidized hyaluronic acid (HA-CHO). The results suggested that the HPZ8 hydrogel could be injected into the wound to form a barrier, facilitating tissue adhesion and rapid hemostasis. After loaded with PDA-ZIF8 nanoparticles, the hydrogel exhibited excellent antioxidant and photothermal antimicrobial properties, which could effectively scavenge ROS, reduce oxidative stress and eliminate bacterial infections. Especially, near-infrared (NIR) irradiation strengthened the photothermal therapy (PTT). Besides, HPZ8 hydrogel could release zinc ions to promote cell migration, angiogenesis and M2 polarization of macrophages, accelerating macrophage transition from inflammation to proliferation stages, thus promoting infected wound healing. Therefore, the HPZ8 multifunctional hydrogel dressing has application prospects for the therapy of chronic infected wounds.
研究领域:
生物材料
·
伤口愈合
·
纳米技术
·
生物医学工程
·
免疫学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Advances
·
2024
·
IF 5.5
Yang Yang,Jian Cao,Hongmei Gu,Jiajia Liu,Jianhua Xue,Qiang Xue,Xianchen Liu,Yong Hu
Chemodynamic therapy (CDT) has played an important role in osteosarcoma (OS) treatment. However, the insufficient content of endogenous H 2 O 2 and high expression of glutathione (GSH) in tumor tissues limit the antitumor efficacy of CDT. In this work, we developed polydopamine (PDA) coated and CuO 2 NPs loaded ZIF8 nanoparticles (CuO 2 @ZIF8@PDA NPs) for thermally reinforced CDT treatment of OS. The CuO 2 @ZIF8@PDA NPs exhibited excellent stability in neutral solutions while degraded in weakly acidic environments to generate hydrogen peroxide (H 2 O 2 ) and Cu 2+ . Cu 2+ consumes GSH in tumor tissues to generate Cu + . Both Cu 2+ and Cu + catalyzed the decomposition of H 2 O 2 , triggering a Fenton-like reaction to produce hydroxyl radicals (•OH). The PDA coating endowed the nanosystem with photothermal conversion capabilities under near-infrared laser irradiation, further promoting the generation of •OH, and inducing tumor cell death. In vitro experiments demonstrated that CuO 2 @ZIF8@PDA NPs exhibited significant toxicity towards K7M2 cells while remaining non-toxic to normal cells. In vivo studies revealed that under 808 nm laser irradiation, CuO 2 @ZIF8@PDA NPs exhibited stronger killing ability against K7M2 cells than CuO 2 @ZIF8@PDA NPs alone. This system, which combines GSH depletion, intratumoral H 2 O 2 self-generation, and photothermally enhanced CDT, holds great promise for playing a pivotal role in the treatment of osteosarcoma.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）