ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jiajia Wang,Li Li,Ruyi Wei,Renfeng Dong
Here, we report the first PbS quantum dot (QD)-based micromotors with NIR-I light-driven photocatalytic propulsion and NIR-II fluorescence. Under the irradiation of NIR-I light (808 nm), PbS QD-doped cuprous oxide (Cu2O@PbS) micromotors can display efficient propulsion in a variety of biocompatible fuels such as malic acid, glucose, and urea. Among them, the Cu2O@PbS micromotors exhibit the best propulsion performance in a very low concentration of malic acid, with an average speed as high as 11.86 μm/s. The enhanced NIR-I photocatalytic activity of Cu2O@PbS micromotors benefits from the doping of NIR-I PbS QDs that can be excited by NIR-I light and exhibit high electron transport efficiency. The doped PbS QDs can effectively increase the absorption efficiency of the micromotors in the NIR-I region while also inhibiting the recombination of photogenerated electron–hole pairs. Interestingly, due to the presence of NIR PbS QDs, the Cu2O@PbS micromotors demonstrate prominent and stable NIR-II fluorescence (emission wavelength: 1100 nm), which offer promising potential for visualization of their position in vivo. In comparison to other photocatalytic micromotors, the simple fabrication strategy, excellent NIR-II fluorescence, together with the NIR-I light-dependent propulsion behavior of the current Cu2O@PbS micromotors, thus pave the way for further development of advanced smart “robots” for intelligent biomedical applications.
研究领域:
纳米技术
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
ACS Applied Optical Materials
·
2024
·
IF 0
Yonghang Li,Yang Lu,Haonan Ju,Wei Wang,Dong Tu,Hongyu Lu,Jiayu Wang,Hua Zou
Near-infared phosphor-converted light-emitting diodes (NIR pc-LEDs) are next-generation NIR light sources due to their long life, low cost, and compactness. Unfortunately, there is a lack of efficient NIR-II phosphors with high efficiency and large full width at half-maximum (fwhm) that can be excited by violet LED. Here, a series of Cr3+/Ni2+-codoped LiAlSiO4 with unprecedented emission peaking at 1150 nm (∼1000–1400 nm, fwmh ∼191 nm) were synthesized via a solid-state reaction. More importantly, the phosphors exhibit high efficiency and excellent thermal stability under violet emission excitation. Moreover, the NIR pc-LED devices as a NIR-II light source have been fabricated through a combination violet LED and optimized LiAlSiO4:Cr3+/Ni2+ phosphors, which are well applied to high-penetration imaging and nondestructive fruit damage inspection. These results indicate that the LiAlSiO4:Cr3+/Ni2+ phosphors have great potential applications as NIR light sources.
研究领域:
材料科学
·
光学工程
·
电子器件
✓ 已验证
DOI
CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Mianhong Chen,Hua Fan,Zuizhi Lu,Jiayang Song,Xinguo Zhang,Qi Pang,Peican Chen,Liya Zhou
Stable and efficient broadband near-infrared (NIR) emitting phosphors are vital for the next-generation NIR sources. However, it still remains challenging to construct such phosphors, particularly those with a NIR-II window. In this work, using the Cr 3+ -Yb 3+ energy transfer (ET) strategy, the as-synthesized Ca 2 ScTaO 6 :Cr 3+ , Yb 3+ phosphor retains 86.2% of the initial luminescence intensity of Yb 3+ at 373 K with characteristic emissions of both activators ranging from 700 nm to 1200 nm. The occupation of Cr 3+ into both Ta 5+ and Sc 3+ sites is confirmed by X-ray diffraction, time-resolved emission spectrum, and crystal structure. The efficient ET from Cr 3+ to Yb 3+ is revealed by the diffuse reflection spectrum, steady-state and transient fluorescence. As a result, it contributes to the excellent performance of the phosphor. Based on the optimized phosphor, a NIR light-emitting diode is fabricated and demonstrated its advantage in imaging and potential application in information encryption. The result highlights ET as a robust strategy to construct efficient NIR phosphor.
研究领域:
材料科学
·
光学
·
光子学
·
固体物理学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Bo-Mei Liu,Xiao-Xuan Guo,Lu-Yu Cao,Lin Huang,Rui Zou,Zhi Zhou,Jing Wang
The development of phosphor-converted light-emitting diodes (pc-LEDs) in the second near-infrared window (NIR-II, 1000–1700 nm) represents an important, newly emerging, and dynamic field in NIR spectroscopy. Unfortunately, lacking efficient NIR-II phosphors that can be excited by commercial blue LED chips impedes NIR spectroscopy applications. Herein, a donor–acceptor strategy is developed by introducing Cr 3+ sensitizers to greatly enhance the blue-light excitation efficiency of NIR-II-emitting MgO:Cr 3+ ,Ni 2+ phosphor. Consequently, a high-efficiency blue-light-excitable MgO:Cr 3+ ,Ni 2+ phosphor that gives a NIR-II emission at 1335 nm with a full width at half-maximum (FWHM) of 235 nm, is demonstrated. The product has a high internal quantum efficiency of 92.7 % and excellent thermal stability, maintaining 83.0 % of the room temperature emission intensity at 150 °C. Excitingly, the fabricated NIR-II pc-LED device shows a high NIR-II optical power (27.4 mW@350 mA). The performances of the achieved NIR-II pc-LED are almost the best results until now. Additionally, multifunctional applications including nondestructive detection and anti-counterfeiting of the NIR-II light source are demonstrated. These results are pretty crucial for the further development of NIR-II spectroscopy and imaging technology.
研究领域:
材料科学
·
光学工程
·
光谱学
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 42
·2305965
·
IF 19
Xinfeng Tang,Yanhua Zhu,Delong Duan,Xingwu Zhai,Yujian Xia,Tao Xu,Qian Liu,Hui Zhang,Min Zhou
Due to the deep biological penetrability and therapeutic depth, the photothermal therapy over second near-infrared region (NIR-II) is booming against deep-seated tumors. Intensive endeavors are committed to looking for suitable photothermal agents (PTAs), but the progress seems not so satisfied toward the choice of PTA dosage. Herein, a comprehensive parameter, incident photon-to-thermal conversion coefficient (IPTCE), is used to evaluate the overall conversion of PTAs at different dosage, which will benefit for determining the optimized dosage of PTAs in pursuit of complete healing together with reduced long-term damages of nanodrugs. To prove the possibility, a series of anionic solid solution MXenes are chosen as hosts due to their versatile chemical compositions and correspondingly tunable light response. By deconvoluting fundamental structure–composition–property relationships, anionic regulation with extra electron injection leads to tunable free carrier densities and enhanced NIR-II harvesting. Ti 3 C 1.23 N 0.77 with high-level nitrogen exhibits extraordinary extinction coefficient (43.5 L g −1 cm −1 ) than other MXenes. The parameter of IPTCE can guide the choice of PTA concentration for complete photothermal healing in vitro and vivo. This proof-of-principle demonstration highlights synthetically tailoring of the light harvesting over NIR-II biowindow for a given host material by anionic regulation and further optimizes tumor photothermal therapy at low dose.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
癌症治疗
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Sheng Zhang,Zhenyang Liu,Linlin Mao,Jian Wu,Di Zhang,Ruiyuan Liu,Li Qi
High quality visualization of live mammalian embryo is an important requirement for studying fetal development. Photoacoustic tomography (PAT) and optical coherence tomography (OCT) are two advanced imaging modalities that have been utilized for embryonic imaging separately. However, high contrast, multiscale, and deep tissue imaging of embryos in vivo remains challenging. Here, we demonstrate multimodal contrast-enhanced imaging of live embryos by gold nanostar-meditated near-infrared I (NIR-I) PAT and near-infrared II (NIR-II) OCT. We investigate intravenous and intravaginal administration of gold nanostars, and significant enhancement of signal, image contrast, and imaging depth are achieved for both PAT and OCT. Our findings may facilitate detailed studies of the morphological and functional changes during embryonic development.
研究领域:
生物医学工程
·
成像科学
·
发育生物学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Hui Li,Zhong Du,Lijun Zhu,Chi Zhang,Jiabao Xiong,Bingshuai Zhou,Biao Dong,Xueliang Zhang,Nuernisha Alifu
Pioneering approaches for precise tumor removal involve fluorescence-guided surgery, while challenges persist, including the low fluorescence contrast observed at tumor boundaries and the potential for excessive damage to normal tissue at the edges. Lead/cadmium sulfide quantum dots (PbS@CdS QDs), boasting high quantum yields (QYs) and vivid fluorescence, have facilitated advancements in the second near-infrared window (NIR-II, 900–1700 nm). However, during fluorescent surgical navigation operations, hydrophilic coatings of these inorganic nanoparticles (NPs) guarantee biosafety; it also comes at the expense of losing a significant portion of QY and NIR-II fluorescence, causing heightened damage to normal tissues caused by cutting edges. Herein, we present hydrophilic core–shell PbS@CdS@PEG NPs with an exceptionally small diameter (∼8 nm) and a brilliant NIR-IIb (1500–1700 nm) emission at approximately 1600 nm. The mPEG-SH (MW: 2000) addresses the hydrophobicity and enhances the biosafety of PbS@CdS QDs. In vivo fluorescence-guided cervical tumor resection becomes achievable immediately upon injection of an aqueous solution of PbS@CdS@PEG NPs. Notably, this approach results in a significantly reduced thickness (100–500 μm) of damage to normal tissues at the margins of the resected tumors. With a high QY (∼30.2%) and robust resistance to photobleaching, NIR-IIb imaging is sustained throughout the imaging process.
研究领域:
生物医学工程
·
纳米技术
·
癌症研究
·
医学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHYTOCHEMICAL ANALYSIS
·
2024
·
IF 3
Kaidi Lv,Chunling Yin,Fang Li,Wenbo Chen,Liuchuang Zhao,Zhimin Liu,Leqian Hu
Introduction Quality evaluation of Huang-qin is significant to ensure its clinical efficacy. Objective This study aims to establish an accurate, rapid and comprehensive Huang-qin quality evaluation method to overcome the time-consuming and laborious shortcomings of traditional herbal medicine quality assessment methods. Methods The contents of baicalin, baicalein and scutellarin in Huang-qin from five different origins were analyzed by FT-IR and NIR spectra combined with multivariate data technology. The quality of Huang-qin from different origins was evaluated by TOPSIS and consistency analysis based on the content of three active ingredients. The correlation between ecological factors and the accumulation of active ingredients was explored. Results Satisfactory prediction results of PLS models were obtained. Relatively, the model based on FT-IR combined with the PLS regression method has higher R 2 and smaller RMSE than the NIR combined with the PLS method. TOPSIS and consistency analysis results showed that the quality of Huang-qin from different geographical origins was significantly different. The results showed that the quality of Huang-qin produced in Shanxi Province was the best among the five origins studied. The results also found that the quality of Huang-qin in different growing areas of the same origin was not completely consistent. The correlation study showed that altitude, sunshine duration and rainfall were the main factors that caused the quality difference of medicinal materials in different geographical origins. Conclusion This study provides a reference for the rapid quantitative analysis of the active components of herbal medicine and the quality evaluation of them.
研究领域:
中药学
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分析化学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2025
·
IF 4.3
Yuxiang Gao,Rong Ma,Lijun Zhu,Zhong Du,Jiabao Xiong,Chi Zhang,Xueliang Zhang,Cailing Ma,Nuernisha Alifu
Near-infrared-II (NIR-II, 900–1700 nm) fluorescence imaging as one of the emerging imaging methods has shown the advantages of excellent spatial resolution and sensitivity. In order to obtain high-quality NIR-II fluorescence images and effective treatment results, it is essential to develop theranostic fluorescent nanoprobes with good tumor targeting and treatment capabilities. Herein, we designed and synthesized novel NIR-II fluorescent theranostic nanoprobes based on the organic dye IR783. IR783 was further encapsulated into liposomes, along with the chemotherapeutic drug doxorubicin (DOX) and the cervical cancer-targeting peptide TMTP1 (NVVRQ), to construct integrated nanoprobes for imaging and treatment. The constructed IR-DT nanoprobes, with its good tumor targeting ability, exhibit excellent imaging performance and significant therapeutic effects. With its powerful imaging capabilities, the IR-DT nanoprobes can achieve high-resolution fluorescence imaging of blood vessels, tumor lesions, and sentinel lymph nodes and could dynamically monitor the dissolution of carotid artery thrombi. The treatment results demonstrate that the nanoprobes possess significant advantages in both tumor-targeting capability and therapeutic efficacy. These findings suggest that it holds great potential to be developed into a theranostic nanoprobe for cervical cancer.
研究领域:
生物医学工程
·
分子影像学
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Xiuna Tian,Youfeng Wen,Hongjian Dou,Lingyuan Wu,Changjun Wang,Youzi Zhang
In the clinical diagnosis and treatment of diseases, there is an urgent need to find suitable materials for real-time temperature monitoring of biological tissues. The paper provides a detailed study of the effects of Nd 3+ doping concentration on the negative thermal expansion performance and NIR fluorescence properties of Sc 2 (MoO 4 ) 3 . The results obtained from Rietveld refinement of in-situ XRD data indicates that high concentration of Nd 3+ doping significantly influences the negative thermal expansion performance of the material, as well as alters the temperature-dependent changes in NIR fluorescence intensity and lifetime. In addition, a NIR fluorescence lifetime temperature probe doped with Nd 3+ /Yb 3+ /Er 3+ has been constructed. When the temperature increased from 303 K to 403 K, the fluorescence intensity of the probe at 1538 nm increased by a factor of 127.5. Furthermore, as the temperature rose from 323 K to 403 K, the fluorescence lifetime of the probe at 1538 nm extended from 41.93 μs to 204 μs. By utilizing the lifetime of Er 3+ for temperature sensing, a relative sensitivity of 6.03%K −1 was achieved at 323 K, indicating significant potential application value of this probe in the field of biological temperature measurement.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Daoming Zhu,Meng Lyu,Qinqin Huang,Meng Suo,Ying Liu,Wei Jiang,Yanhong Duo,Kelong Fan
Multifunctional gold (Au)-based nanomaterials with high atomic number (symbol Z) and strong absorbance in the second near-infrared window (NIR-II) property are emerging as promising candidates for tumor thermo-radiotherapy. The main limitations of applying Au-based nanomaterials to biomedical studies include the absence of active tumor-targeting ability, penetrating efficiency, and stability. In this study, we present a novel type of tumor cell-derived stellate plasmonic exosomes (TDSP-Exos) for penetrative targeted tumor NIR-II thermo-radiotherapy and photoacoustic imaging. The TDSP-Exos are abundantly and easily produced by the incubation of tumor cells with gold nanostars, based on which gold nanostars promote the exocytosis of exosomes from tumor cells. Compared with bare gold nanostars, the TDSP-Exos exhibit pronounced accumulation in deep tumor tissues and perform well in both PA imaging and NIR-II thermo-radiotherapy against the tumor. Moreover, the TDSP-Exos improve tumor hypoxia to enhanced radiotherapy by NIR-II photothermal therapy. This work indicates that the tumor cell-derived exosomes have the potential to function as a universal carrier of photothermal agents for targeted tumor NIR-II thermo-radiotherapy.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 11
·期 15
·2200467
·
IF 11.092
Wansu Zhang,Shangyu Chen,Pengfei Sun,Shuai Ye,Quli Fan,Jun Song,Pengju Zeng,Junle Qu,Wai-Yeung Wong
The luminescence of traditional phosphorescence-based hypoxia probes is limited to the visible and first near-infrared wavelength regions (<1000 nm), which has defects of higher light scattering and lower penetration depth in contrast with the second near-infrared wavelength window (NIR-II, 1000–1700 nm) for optical bioimaging. Herein, 5,15-bis(2,6-bis(dodecyloxy)phenyl)-porphyrin platinum(II) (PpyPt) with J-aggregation induced NIR-II phosphorescence is reported. J-aggregates of PpyPt are confirmed by the X-ray diffraction data in the crystalline state. Moreover, the emission and excitation spectra of PpyPt in the solid states reveal NIR-II luminescence feature of PpyPt in J-aggregates. More importantly, by preparation of water-soluble PpyPt nanoparticles (PpyPt NPs 4.76 ) with J-aggregates, it has NIR-II phosphorescent lifetime of microseconds and good oxygen-sensitivity in water. Moreover, the good biological hypoxia-sensing potential of PpyPt NPs 4.76 is demonstrated in cells and 4T1-tumor-bearing mice. This study provides an efficient strategy to design NIR-II phosphorescent probe for sensitive tumor-hypoxia detection through the construction of J-aggregates.
研究领域:
生物医学工程
·
光学成像
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）