The succinate dehydrogenase inhibitor (SDHI) fungicides have been extensively used in agriculture, and some of their potential ecological risks to aquatic organisms have been demonstrated recently. Sedaxane (SDX) is a broad spectrum SDHI fungicide. Despite being extensively used in environment, little is known about its potential developmental effect in zebrafish embryo. This study examined the effects of which SDX triggered in zebrafish through embryonic development assessments. Results show that SDX induced mortality, hatch delay and failure in zebrafish embryos, which were concentration dependent. In addition, several developmental abnormalities were observed at 2 mg/L and higher concentrations, including edema, microcephaly, body deformation, and swim bladder not fully inflated. SDX exposure influenced reactive oxygen species , malondialdehyde, peroxidase, glutathione S-transferase, superoxide dismutase and glutathione in live larvae, which indicated that oxidative stress was caused in zebrafish. Furthermore, SDX induced decrease of succinate dehydrogenase activity in zebrafish larvae. These results provide toxicological data of SDX on developing zebrafish embryo, which could be help for further understanding the potential risk on the environment.
Shanshan Di,Yunye Xie,Tao Cang,Zhenzhen Liu,Yanyan Chu,Huiyu Zhao,Peipei Qi,Zhiwei Wang,Xinquan Wang
A comprehensive evaluation of chiral pesticide at the stereoisomeric level is an effective strategy to improve efficiency and reduce risk on foods. For chiral sedaxane with four stereoisomers , there were 517–1013 fold differences in bioactivity for three kinds of phytopathogens and 3.73 fold differences in toxicity against model organism ( Danio rerio ) between the best ( trans -1 R 2 S -sedaxane) and worst stereoisomer ( cis -1 S 2 S -sedaxane). Trans -1 R 2 S -sedaxane had the strongest affinity with the active site than other stereoisomers, which might contribute to the highest bioactivity. Trans -sedaxane was 28.2–331 fold more effective than cis -sedaxane. The dissipation half-lives of sedaxane stereoisomers ranged from 3.28 to 30.7 d in the test crops and soils. Trans -1 S 2 R -sedaxane and cis -1 S 2 S -sedaxane were preferentially dissipated in corn plants, while the preferential dissipation of trans -1 R 2 S -sedaxane was found in wheat plants, potato plants and corn soil. The preferential dissipation of trans -sedaxane in corn plants, wheat plants, potato plants and corn soil would be environmentally friendly.
危险品化学品经营许可证（带存储）