为了获得访问"阿拉丁铁蛋"实时聊天框的流畅支持体验,建议您使用Chrome浏览器或选择360浏览器极速模式(如何切换极速模式?),感谢您选择我们!

1-(1-金刚烷基)乙基胺盐酸盐

M2质子通道抑制剂
规格或纯度: 99%
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
A118559-1g
1g 现货 Stock Image
A118559-5g
5g 现货 Stock Image
A118559-25g
25g 现货 Stock Image
A118559-100g
100g 现货 Stock Image
A118559-500g
500g 现货 Stock Image
查看相关系列
含氮化合物 非杂环砌块

基本描述

别名 盐酸左氧氟沙星 盐酸盐|1-金刚烷乙胺 盐酸盐|α-甲基-1-金刚烷甲胺盐酸盐|盐酸金刚乙胺
英文别名 Rimantadine hydrochloride|1501-84-4|Flumadine|Rimantadine HCL|Meradane|1-(1-ADAMANTYL)ETHYLAMINE HYDROCHLORIDE|EXP 126|alpha-Methyl-1-adamantanemethylamine hydrochloride|1-(Adamantan-1-yl)ethanamine hydrochloride|Rimantadine (hydrochloride)|1-(1-Aminoethy
规格或纯度 99%
英文名称 1-(1-Adamantyl)ethylamine hydrochloride
生化机理 M2质子通道抑制剂。在体内抑制甲型流感病毒。与盐酸金刚烷胺相比,具有更高的血脑屏障通透性。口服具有活性。
运输条件 常规运输
备注 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。
产品介绍


Product Application:

1-(1-Adamantyl)ethylamine hydrochloride is indicated for the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults (17 years and older).

名称和标识符

PubChem SID 488182078
IUPAC Name 1-(1-adamantyl)ethanamine;hydrochloride
INCHI InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H
InChi Key OZBDFBJXRJWNAV-UHFFFAOYSA-N
Canonical SMILES CC(C12CC3CC(C1)CC(C3)C2)N.Cl
Isomeric SMILES CC(C12CC3CC(C1)CC(C3)C2)N.Cl
WGK Germany 3
RTECS AU4717000
PubChem CID 15165
分子量 215.77
Reaxy-Rn 3623918

化学和物理性质

溶解性 Freely soluble in water.
熔点 375°C

安全和危险性(GHS)

象形图
ghs07

Harmful

信号词 Warning
危险声明 H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
预防措施声明 P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319
WGK Germany 3
RTECS AU4717000
Reaxy-Rn 3623918
Merck Index 8224
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

质检证书(COA)

质检报告(COA)

输入批号以搜索COA:

相关文档

质检报告COA

请输入批号:


产品问答

产品问答

登录提交问题 Hover me 请先登录再提交问题
您提交该产品问题后,我们会在1-2个工作日内给您答复,您可以登录"我的账号",然后点击"我的产品问答"查看答案

参考文献

1. Segovia M et al..  (2019)  Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation..  Cancer Cell,  35  (5):  (767-781.e6).  [PMID:31085177]
2. G G U Rohde.  (2011-08-03)  [Influenza : clinical symptoms, diagnostics and therapy]..  Der Internist,  52  ((9)):  (1047-1052).  [PMID:21809066]
3. Belen Puente,Esther Hernandez,Susana Perez,Luis Pablo,Esther Prieto,Maria Angeles Garcia,Miguel Angel Bregante.  (2011-11-15)  Determination of memantine in plasma and vitreous humour by HPLC with precolumn derivatization and fluorescence detection..  Journal of chromatographic science,  49  ((10)):  (745-752).  [PMID:22080801]
4. Linh Tran,Sy Bing Choi,Belal O Al-Najjar,Muhammad Yusuf,Habibah A Wahab,Ly Le.  (2011-12-14)  Discovery of potential M2 channel inhibitors based on the amantadine scaffold via virtual screening and pharmacophore modeling..  Molecules (Basel, Switzerland),  16  ((12)):  (10227-10255).  [PMID:22158591]
5. Sander A A Kooijmans,Danielle Senyschyn,Muguntha M Mezhiselvam,Julia Morizzi,Susan A Charman,Babette Weksler,Ignacio-Andres Romero,Pierre-Olivier Couraud,Joseph A Nicolazzo.  (2012-02-23)  The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine..  Molecular pharmaceutics,  ((4)):  (883-893).  [PMID:22352408]
6. Jonathan Hsu,Nancy Santesso,Reem Mustafa,Jan Brozek,Yao Long Chen,Jessica P Hopkins,Adrienne Cheung,Gayane Hovhannisyan,Liudmila Ivanova,Signe A Flottorp,Ingvil Saeterdal,Arthur D Wong,Jinhui Tian,Timothy M Uyeki,Elie A Akl,Pablo Alonso-Coello,Fiona Smaill,Holger J Schünemann.  (2012-03-01)  Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies..  Annals of internal medicine,  156  ((7)):  (512-524).  [PMID:22371849]
7. Tijana Ivanovic,Rutger Rozendaal,Daniel L Floyd,Milos Popovic,Antoine M van Oijen,Stephen C Harrison.  (2012-03-14)  Kinetics of proton transport into influenza virions by the viral M2 channel..  PloS one,  ((3)):  (e31566-e31566).  [PMID:22412838]
8. Loren B Andreas,Matthew T Eddy,James J Chou,Robert G Griffin.  (2012-04-07)  Magic-angle-spinning NMR of the drug resistant S31N M2 proton transporter from influenza A..  Journal of the American Chemical Society,  134  ((17)):  (7215-7218).  [PMID:22480220]
9. Lora Simeonova,Galina Gegova,Angel S Galabov.  (2012-05-24)  Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice..  Antiviral research,  95  ((2)):  (172-181).  [PMID:22617756]
10. V A Shibnev,T M Garaev,M P Finogenova,E S Shevchenko,E I Burtseva.  (2012-07-21)  New adamantane derivatives can overcome resistance of influenza A(H1N1)pdm2009 and A(H3N2) viruses to remantadine..  Bulletin of experimental biology and medicine,  153  ((2)):  (233-235).  [PMID:22816091]
11. Yuxin Zhang,Hujun Shen,Mingbo Zhang,Guohui Li.  (2013-01-05)  Exploring the proton conductance and drug resistance of BM2 channel through molecular dynamics simulations and free energy calculations at different pH conditions..  The journal of physical chemistry. B,  117  ((4)):  (982-988).  [PMID:23286443]
12. Bo OuYang,Shiqi Xie,Marcelo J Berardi,Xinhao Zhao,Jyoti Dev,Wenjing Yu,Bing Sun,James J Chou.  (2013-06-07)  Unusual architecture of the p7 channel from hepatitis C virus..  Nature,  498  ((7455)):  (521-525).  [PMID:23739335]
13. George Atiee,Kenneth Lasseter,Sharon Baughman,Amy McCullough,Phil Collis,Alan Hollister,Jaime Hernandez.  (2011-10-01)  Absence of pharmacokinetic interaction between intravenous peramivir and oral oseltamivir or rimantadine in humans..  Journal of clinical pharmacology,  52  ((9)):  (1410-1419).  [PMID:21960669]
14. Saumil Doshi,Laurie Kamimoto,Lyn Finelli,Alejandro Perez,Arthur Reingold,Ken Gershman,Kimberly Yousey-Hindes,Kathryn Arnold,Patricia Ryan,Ruth Lynfield,Craig Morin,Joan Baumbach,Emily B Hancock,Nancy M Bennett,Shelley Zansky,Ann Thomas,William Schaffner,Alicia M Fry.  (2011-10-21)  Description of antiviral treatment among adults hospitalized with influenza before and during the 2009 pandemic: United States, 2005-2009..  The Journal of infectious diseases,  204  ((12)):  (1848-1856).  [PMID:22013219]
15. Georgina Cirrincione-Dall,Barbara J Brennan,Rosa M Ballester-Sanchis,Mercidita T Navarro,Brian E Davies.  (2011-11-01)  Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: an open-label, multiple-dose, randomized, crossover study..  Journal of clinical pharmacology,  52  ((8)):  (1255-1264).  [PMID:22039289]
16. Rafal M Pielak,Kirill Oxenoid,James J Chou.  (2011-11-15)  Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses..  Structure (London, England : 1993),  19  ((11)):  (1655-1663).  [PMID:22078564]
17. Mona Alqazzaz,Andrew J Thompson,Kerry L Price,Hans-Georg Breitinger,Sarah C R Lummis.  (2012-01-03)  Cys-loop receptor channel blockers also block GLIC..  Biophysical journal,  101  ((12)):  (2912-2918).  [PMID:22208189]
18. Suelen F Sucena,Raphael E F Paiva,Camilla Abbehausen,Ives B Mattos,Marcelo Lancellotti,André L B Formiga,Pedro P Corbi.  (2012-01-20)  Chemical, spectroscopic characterization, DFT studies and antibacterial activities in vitro of a new gold(I) complex with rimantadine..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  89  ():  (114-118).  [PMID:22257715]
19. Márcia G Alves Galvão,Marilene Augusta Rocha Crispino Santos,Antonio Jl Alves da Cunha.  (2012-01-20)  Amantadine and rimantadine for influenza A in children and the elderly..  The Cochrane database of systematic reviews,  ():  (CD002745-CD002745).  [PMID:22258950]
20. Guang-Quan Wang,Yan-Fang Qin,Li-Ming Du,Jun-Fei Li,Xu Jing,Yin-Xia Chang,Hao Wu.  (2012-09-11)  Determination of amantadine and rimantadine using a sensitive fluorescent probe..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  98  ():  (275-281).  [PMID:22959366]
21. Loren B Andreas,Alexander B Barnes,Björn Corzilius,James J Chou,Eric A Miller,Marc Caporini,Melanie Rosay,Robert G Griffin.  (2013-03-14)  Dynamic nuclear polarization study of inhibitor binding to the M2(18-60) proton transporter from influenza A..  Biochemistry,  52  ((16)):  (2774-2782).  [PMID:23480101]