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维拉佐酮

规格或纯度: ≥98%

CAS编号: 163521-12-8
分子式: C₂₆H₂₇N₅O₂
分子量: 441.52
PubChem编号: 6918314

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货号 (SKU)	包装规格	是否现货	价格	数量
V124992-2mg	2mg	期货
V124992-10mg	10mg	现货
V124992-50mg	50mg	现货

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5-HT1A receptor Agonist 5-HT4 receptor Agonist D2 receptor Agonist D3 receptor Agonist H1 receptor Agonist SERT Inhibitor

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基本描述

别名	维拉佐酮
英文别名	5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl)-1-benzofuran-2-carboxamide\|EMD 515259\|2,5-bis(p-aminophenyl)-1,3,4-oxadiazole\|NCGC00371130-06\|VILAZODONE [VANDF]\|EINECS 219-401-9\|N06AX24\|SGEGOXDYSFKCPT-UHFFFAOYSA-N\|NCGC00371130-03\|VILAZODONE [WHO-DD]\|
规格或纯度	≥98%
英文名称	Vilazodone
生化机理	Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Vilazodone is an inhibitor of ST (serotonin transporter and uptake) (IC50 = 0.5 nM) and SR-1A activator (partial agonist) (IC50 = 0.2 nM; IA = ~60-70%).An inhibitor of ST and activator of SR-1A Vilazodone is an inhibitor of ST (serotonin transporter and uptake) (IC50 = 0.5 nM) and SR-1A activator (partial agonist) (IC50 = 0.2 nM; IA = ~60-70%). An inhibitor of ST and activator of SR-1A

名称和标识符

IUPAC Name	5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide
INCHI	InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)
InChi Key	SGEGOXDYSFKCPT-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
Isomeric SMILES	C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
PubChem CID	6918314
分子量	441.52

数据库链接

ChEMBL Ligand	CHEMBL439849
PubChem CID	6918314
CAS Registry No.	163521-12-8
DrugBank Ligand	DB06684
Wikipedia	Vilazodone
PEP	vilazodone
RCSB PDB Ligand	YG7
DrugCentral Ligand	4223
GPCRdb Ligand	vilazodone

化学和物理性质

溶解性	DMSO

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参考文献

1. Dawson LA, Watson JM. (2009) Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders.. CNS Neurosci Ther, 15 (2): (107-17). [PMID:19499624]
2. Heinrich T, Böttcher H, Gericke R, Bartoszyk GD, Anzali S, Seyfried CA, Greiner HE, Van Amsterdam C. (2004) Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.. J Med Chem, 47 (19): (4684-92). [PMID:15341484]
3. Hughes ZA, Starr KR, Langmead CJ, Hill M, Bartoszyk GD, Hagan JJ, Middlemiss DN, Dawson LA. (2005) Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.. Eur J Pharmacol, 510 (1-2): (49-57). [PMID:15740724]
4. Zhu XY, Etukala JR, Eyunni SV, Setola V, Roth BL, Ablordeppey SY. (2012) Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.. Eur J Med Chem, 53 (13): (124-32). [PMID:22520153]

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