Aldolase catalyzes a key reaction in glycolysis and energy production. Aldolase is used to convert fructose 1,6-diphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Aldolase, from rabbit muscle has been used for stereospecific deprotonation at DHAP C3
ALDO: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. ALDOB: Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (By similarity). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (By similarity).
生物活性
≥10 U/mg protein
种属
兔(Rabbit)
来源
天然
预测分子量
158 kDa
CAS编号和信息
9024-52-6
酶学委员会编号
EC 4.1.2.13
分子类型
酶
储存与运输
物理形态
液体
储存缓冲液
Crystalline suspension in 2.5 M (NH4)2SO4, 0.01 M Tris, pH 7.5, 0.001 M EDTA.
G1605065
危险品化学品经营许可证（带存储）