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交链孢酚

3篇引用文献
  • ≥96%
有货

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
A134401-1mg
 1mg 现货 Stock Image
A134401-5mg
 5mg 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
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Cell Cycle/DNA Damage (2603) Topoisomerase (151)
main product photo

基本描述

英文别名 Alternariol, analytical standard | CHEBI:64983 | ACon0_000598 | NCGC00180653-01 | A867945 | Alternariol from Alternaria sp., ~96% | CEBXXEKPIIDJHL-UHFFFAOYSA-N | Alternariol from Alternaria sp. | Alternariol | MFCD00133068 | Q410677 | Alternariol 3,4',5-T
规格或纯度 ≥96%
英文名称 Alternariol
生化机理 Alternaria 真菌毒素通常与收获后未干燥的粮食谷物有关。Alternaria霉菌毒素引起的病害会导致果实出现色晕，叶片出现斑点。Alternariol（AOH）对微生物和哺乳动物细胞具有细胞毒性和胎毒作用。AOH 对细胞增殖有抑制作用，并具有雌激素功能。
应用 A mycotoxin with anti-proliferative activity
来源 from Alternaria sp
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
产品介绍

Alternariol, a mycotoxin, has been shown to inhibit the short action current across transepithelial sodium pumps. This compound has also demonstrated the ability to have acute cytotoxic effects on cells and cause a halt in cell proliferation. At high doses, alternariol has been reported to induce cell growth arrest in G2/M phase. Additional experiments sμggest that alternariol interacts with DNA by intercalation and causes DNA damage. Alternariol is an inhibitor of AChE and BChE.A mycotoxin with anti-proliferative activity

Product Description：

Alternariol belongs to the dibenzo-pyrones chemical group. It is a mycotoxin present in indoor air, soil and plants.


Product Application：

Alternariol from Alternaria sp. may be used as a calibration standard in reverse phase high-performance liquid chromatography (HPLC) and UV-spectrum analysis. It may also be used to spike wholemeal wheat flour for wet baking studies.

AI解读

关联靶点（人）

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IGF1R Tclin Insulin-like growth factor I receptor (8605 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CSNK2A1 Tchem Casein kinase II alpha (3512 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SRC Tclin Tyrosine-protein kinase SRC (10310 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PTK2 Tclin Focal adhesion kinase 1 (4730 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MET Tclin Hepatocyte growth factor receptor (10718 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FLT4 Tclin Vascular endothelial growth factor receptor 3 (3216 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AKT1 Tchem Serine/threonine-protein kinase AKT (9192 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
FLT3 Tclin Tyrosine-protein kinase receptor FLT3 (13481 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TEK Tclin Tyrosine-protein kinase TIE-2 (3348 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PLK4 Tchem Serine/threonine-protein kinase PLK4 (1882 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A498 (42825 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ACHN (49357 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CAKI-1 (44928 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CCRF-CEM (65223 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
COLO 205 (50209 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DLD-1 (17511 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
DMS-273 (14108 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
K562 (73714 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KM12 (47707 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
M14 (47487 活性数据)
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MCF7 (126967 活性数据)
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MOLT-4 (49676 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-3 (48710 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-4 (44535 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-5 (45555 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
OVCAR-8 (47708 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RXF 393 (41971 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
RXF 631 (11415 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SF-295 (48000 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-2 (46422 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-28 (48833 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-MEL-5 (47095 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SK-OV-3 (52876 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SN12C (47755 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNB-19 (46794 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SNB-78 (14240 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TK-10 (45540 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
U-251 (51189 活性数据)
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UACC-257 (46019 活性数据)
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关联靶点（其它种属）

Streptococcus pneumoniae (31063 活性数据)
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Pseudomonas aeruginosa (123386 活性数据)
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Agrobacterium tumefaciens (620 活性数据)
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Enterobacter cloacae (7976 活性数据)
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Klebsiella pneumoniae (43867 活性数据)
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Staphylococcus aureus (210822 活性数据)
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Staphylococcus haemolyticus (1695 活性数据)
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Acinetobacter baumannii (41033 活性数据)
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Escherichia coli (133304 活性数据)
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Enterococcus faecium (13803 活性数据)
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Bacillus subtilis (32866 活性数据)
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Pichia kudriavzevii (7448 活性数据)
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Aspergillus fumigatus (16427 活性数据)
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Candida albicans (78123 活性数据)
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L5178Y (1809 活性数据)
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RAW264.7 (28094 活性数据)
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Pyricularia oryzae (1832 活性数据)
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Xanthomonas euvesicatoria (74 活性数据)
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Aspergillus ficuum (42 活性数据)
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Pseudomonas amygdali pv. lachrymans (49 活性数据)
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作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IUPAC Name 3,7,9-trihydroxy-1-methylbenzo[c]chromen-6-one
INCHI InChI=1S/C14H10O5/c1-6-2-7(15)5-11-12(6)9-3-8(16)4-10(17)13(9)14(18)19-11/h2-5,15-17H,1H3
InChi Key CEBXXEKPIIDJHL-UHFFFAOYSA-N
Canonical SMILES CC1=CC(=CC2=C1C3=C(C(=CC(=C3)O)O)C(=O)O2)O
Isomeric SMILES CC1=CC(=CC2=C1C3=C(C(=CC(=C3)O)O)C(=O)O2)O
WGK Germany 3
RTECS HP8757000
PubChem CID 5359485
分子量 258.23
Beilstein号 244839

化学和物理性质

溶解性 DMSO (Slightly), Methanol (Slightly)
敏感性 对光，湿度敏感
熔点 >300°C (dec.)
分子量 258.230 g/mol
XLogP3 2.900
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 0
精确质量Exact Mass 258.053 Da
单同位素质量Monoisotopic Mass 258.053 Da
拓扑极表面积Topological Polar Surface Area 87.000 Ų
重原子数Heavy Atom Count 19
形式电荷Formal Charge 0
复杂度Complexity 371.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS06
信号词 Danger
危险声明

H300: 吞咽致命

H310: 与皮肤接触致命

H330: 吸入致命
预防措施声明

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P321: 特殊处理（请参阅此标签上的...）。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P284: 如果通风不良，请佩戴呼吸防护装置。

P271: 仅在室外或通风良好的地方使用。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P403+P233: 存放在通风良好的地方。保持容器密闭。

P330: 漱口

P262: 不要进入眼睛、皮肤或衣服。

P320: 迫切需要特殊治疗（请参阅此标签上的...）。

P361+P364: 立即脱掉所有沾染的衣服，清洗后方可重新使用。

P301+P316: 如果吞咽：立即寻求紧急医疗救助。

P316: 立即寻求紧急医疗救助。
WGK Germany 3
RTECS HP8757000
个人防护装备 Eyeshields， Faceshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges

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找到3个结果

批号(Lot Number) 证书类型 日期 货号
G2219045 分析证书 24-05-15 A134401
G2219046 分析证书 24-05-15 A134401
K2112038 分析证书 23-08-17 A134401

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Hu Xiaopeng, Xia Yide, Liu Yiwei, Zhao Faqiong, Zeng Baizhao.  (2021)  Determination of patulin using dual-dummy templates imprinted electrochemical sensor with PtPd decorated N-doped porous carbon for amplification.  MICROCHIMICA ACTA,  188  (5): (1-9).  [PMID:33797604] [10.1007/s00604-021-04812-2]
2. Feng Wang, De-Bin Wan, Yu-Dong Shen, Yuan-Xin Tian, Zhi-Li Xiao, Zhen-Lin Xu, Jin-Yi Yang, Yuan-Ming Sun, Bruce D. Hammock, Hong Wang.  (2021)  Development of a chemiluminescence immunoassay for detection of tenuazonic acid mycotoxin in fruit juices with a specific camel polyclonal antibody.  Analytical Methods,  13  (15): (1795-1802).  [PMID:33885655] [10.1039/D1AY00200G]
3. Feng Wang, Zhen-Feng Li, Yuan-Yuan Yang, De-Bin Wan, Natalia Vasylieva, Yu-Qi Zhang, Jun Cai, Hong Wang, Yu-Dong Shen, Zhen-Lin Xu, Bruce D. Hammock.  (2020)  Chemiluminescent Enzyme Immunoassay and Bioluminescent Enzyme Immunoassay for Tenuazonic Acid Mycotoxin by Exploitation of Nanobody and Nanobody–Nanoluciferase Fusion.  ANALYTICAL CHEMISTRY,  92  (17): (11935–11942).  [PMID:32702970] [10.1021/acs.analchem.0c02338]

参考文献

1. Hu Xiaopeng, Xia Yide, Liu Yiwei, Zhao Faqiong, Zeng Baizhao.  (2021)  Determination of patulin using dual-dummy templates imprinted electrochemical sensor with PtPd decorated N-doped porous carbon for amplification.  MICROCHIMICA ACTA,  188  (5): (1-9).  [PMID:33797604] [10.1007/s00604-021-04812-2]
2. Feng Wang, De-Bin Wan, Yu-Dong Shen, Yuan-Xin Tian, Zhi-Li Xiao, Zhen-Lin Xu, Jin-Yi Yang, Yuan-Ming Sun, Bruce D. Hammock, Hong Wang.  (2021)  Development of a chemiluminescence immunoassay for detection of tenuazonic acid mycotoxin in fruit juices with a specific camel polyclonal antibody.  Analytical Methods,  13  (15): (1795-1802).  [PMID:33885655] [10.1039/D1AY00200G]
3. Feng Wang, Zhen-Feng Li, Yuan-Yuan Yang, De-Bin Wan, Natalia Vasylieva, Yu-Qi Zhang, Jun Cai, Hong Wang, Yu-Dong Shen, Zhen-Lin Xu, Bruce D. Hammock.  (2020)  Chemiluminescent Enzyme Immunoassay and Bioluminescent Enzyme Immunoassay for Tenuazonic Acid Mycotoxin by Exploitation of Nanobody and Nanobody–Nanoluciferase Fusion.  ANALYTICAL CHEMISTRY,  92  (17): (11935–11942).  [PMID:32702970] [10.1021/acs.analchem.0c02338]

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