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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor ( IC 50 =12.12 µM). AV123 blocks the TNF-α-induced necroptotic ( EC 50 =1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases.