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224,000+ 科研产品 · 三重ISO认证 · 每个产品均提供COA和SDS · 现货产品当日发货

活化蛋白C (APC)

Name: 活化蛋白C (APC)
SKU: A1440682
Availability: InStock

CAS: 925910-74-3 货号: A1440682

COA

有货

级别和纯度: 生物活性 ? ActiBioPure™ ? 天然 ? 高性能 ? EnzymoPure™ ? 来源于人血浆; 冻干前浓度：见COA

生物活性

见COA

规格

库存

价格

数量

10μg

A1440682-10μg

现货

¥1,499.90

25μg

A1440682-25μg

现货

¥2,999.90

100μg

A1440682-100μg

现货

¥6,599.90

1mg

A1440682-1mg

期货

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概述规格储存与运输技术文档高级数据质检证书（CoA,COO,BSE/TSE 和分析图谱) 技术文档和文章溶液计算器

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为什么选择此级别

ActiBioPure™,EnzymoPure™,天然,生物活性,高性能级，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

2-8°C储存。低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

概述

Activated Protein C (APC) is a serine protease derived from the two chain vitamin K dependent zymogen, Protein C. APC inhibits blood coagulation through the selective inactivation of the cofactors Va and VIIIa. APC is prepared from protein C by activation with purified thrombin. This thrombin is removed after activation by ion exchange chromatography. Activated Protein C purity is determined by SDS-PAGE and shows complete reduction upon incubation with 2-mercaptoethanol.

Buffer composition = 20 mM Tris-HCl/0.1 M NaCl/ pH 7.4

Extinction Coefficient (1%) = 14.5

Molecular Weight = 56,000 daltons

The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.

规格

产品名称

活化蛋白C (APC)

英文别名

规格或纯度

生物活性, ActiBioPure™, 天然, 高性能, EnzymoPure™, 来源于人血浆; 冻干前浓度：见COA

生化机理

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Miscellaneous: Calcium also binds, with stronger affinity to another site, beyond the GLA domain. This GLA-independent binding site is necessary for the recognition of the thrombin-thrombomodulin complex. Post-translational: Carboxylated by vitamin K-dependent GGCX to form gamma-carboxyglutamate; these residues are essential for the binding of calcium. N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.

生物活性

见COA

种属

人(Human)

来源

天然

预测分子量

56 kDa

CAS编号和信息

925910-74-3

分子类型

酶

产品线

biological_products

储存与运输

物理形态

冻干(Lyophilized)

储存缓冲液

Lyophilized from 20 mM Tris-HCl, 0.1 M NaCl, pH 7.4.

浓度

来源于人血浆; 冻干前浓度：见COA

复溶

We suggest hydrating the protein with a good quality water to the original volume (See COA). After hydration aliquot into a useful (one time use) size and freeze at -80℃.

储存条件

2-8°C储存

运输条件

低温运输

稳定性与储存

长期储存2-8℃；复溶后建议分装，避免反复冻融。