Androgen receptor-IN-6 (compound 16) is an orally available androgen receptor ( Androgen Receptor ) potent inhibitor (IC 50 =0.12 μM in vitro ), targeting the disordered N-terminal domain (NTD). Androgen receptor-IN-6 has good Caco2 cell membrane permeability and has an oral activity (F/%) of 16% in male CD-1 mice.