L2214842计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
产品介绍
Autocamtide-2-related inhibitory peptide (TFA) 是高度特异性的、CaMKII 的有效抑制剂，其 IC50 值为 40 nM。
Application
Autocamtide 2-related inhibitory peptide has been used:
To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophages
To study its influence on oxidative stress associated with neural cell death after hypoxia-ischemia, using neonatal hippocampal slice cultures
To quench the phosphorylation of recombinant synGA (GTPase-activating protein) induced by CaMKII
规格
产品名称
Autocamtide-2-related inhibitory peptide TFA
别名
Autocamtide-2 相关抑制肽 TFA
英文别名
[Ala9]-Autocamtide 2, AIP | Autocamtide-2-Related Inhibitory Peptide
规格或纯度
≥98%
生化机理
Calmodulin kinase II facilitates the calcium-dependent L-type calcium channels. Autocamtide 2-related inhibitory peptide action does not influence cAMP (cyclic adenosine monophosphate)-dependent protein kinase II, calmodulin-dependent protein kinase IV and protein kinase C. Increased expression of calmodulin kinase II is observed in structural heart disease, indicated by myocardial infarction. Thus, inhibition of calmodulin kinase II activity might serve as a protective effect against structural heart disease, as it is found to prevent cardiac hypertrophy, dilation and dysfunction.
Potent inhibitor of calmodulin-depentent protein kinase II.
序列
Lys-Lys-Ala-Lru-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu TFA
作用类型
抑制剂
CAS编号和信息
167114-91-2(free)
分子类型
肽
储存与运输
储存条件
-20°C储存
运输条件
超低温运输
技术文档
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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