计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,干燥。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H + , K + - ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.
In Vitro
The mechanism of action of Abeprazan hydrochloride is reversibly binding to H + , K + ‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Abeprazan hydrochloride (DWP14012 hydrochloride) inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
规格
别名
盐酸阿贝拉赞
规格或纯度
≥99%
英文名称
Abeprazan hydrochloride
生化机理
盐酸阿贝普拉赞（DWP14012 盐酸盐）是一种钾竞争性酸阻滞剂。盐酸阿贝普拉赞通过可逆的钾竞争性离子结合抑制 H + , K + - ATP 酶，无需酸激活。盐酸阿贝普拉赞可用于
储存条件
-20°C储存,干燥
运输条件
超低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
446.87
技术文档
高级数据
化学和物理性质
溶解性
DMSO : 25 mg/mL (55.94 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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