计算溶液所需的质量、体积或浓度。
概述
Amylin (8-37), rat is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin (8-37), rat is a weak amylin receptor ( AMY ) antagonist.
In Vitro
Amylin (8-37), rat (Rat amylin-(8-37)) enhances insulin action and alters lipid metabolism in normal and insulin-resistant rats. Amylin (8-37) reduces plasma insulin (P<0.001) and enhances several measures of whole body and muscle insulin sensitivity (P<0.05) in both saline- and hGH-infused rats. Amylin-(8-37) corrects hGH-induced liver insulin resistance, increases basal plasma triglycerides and lowers plasma nonesterified fatty acids in both groups, and reduces muscle triglyceride and total long-chain acyl-CoA content in saline-treated rats (P<0.05). In isolated soleus muscle, Amylin (8-37) blocks amylin-induced inhibition of glycogen synthesis but has no effect in the absence of amylin. Thus 1) hyperamylinemia accompanies insulin resistance induced by hGH infusion; 2) Amylin (8-37) increases whole body and muscle insulin sensitivity and consistently reduces basal insulin levels in normal and hGH-induced insulin resistant rats; and 3) Amylin (8-37) elicits a significant alteration of in vivo lipid metabolism. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Amylin receptor (AMY)
规格
别名
胰淀素 (8-37)，大鼠
规格或纯度
≥99%
英文名称
Amylin (8-37), rat
生化机理
大鼠淀粉样蛋白（8-37）是原生淀粉样蛋白的截短类似物，可选择性地抑制肌肉组织中与胰岛素相关的葡萄糖摄取和糖原沉积。大鼠淀粉样蛋白（8-37）是一种弱淀粉样蛋白受体（AMY）拮抗剂。
储存条件
干燥,-80℃储存
运输条件
特低温运输
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
3200.61
高级数据
化学和物理性质
溶解性
H2O : 50 mg/mL (15.62 mM; Need ultrasonic)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
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技术文档和文章
溶液计算器
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