计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
2-8°C储存,干燥。低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
AMG 837 calcium hydrate is a potent, orally bioavailable and partial agonist of GPR40/FFA1 . AMG 837 calcium hydrate inhibits specific [ 3 H]AMG 837 binding at the human FFA1 receptor with a pIC 50 of 8.13. AMG 837 calcium hydrate could enhance insulin secretion and lower glucose levels in rodents
In Vitro
AMG 837 (1 nM-10 μM) stimulates insulin secretion in a glucose-dependent manner with an EC 50 of 142±20 nM on islets isolated from mice. AMG 837 stimulates Ca 2+ flux with the EC 50 s of 13.5, 22.6 and 31.7 nM for human, mouse and rat receptors in CHO cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AMG 837 (0.03-0.3 mg/kg; p.o. once daily for 21 days) reduces glucose levels and increases insulin levels following glucose challenge in vivo . AMG 837 (0.03-0.3 mg/kg; a single p.o.) improves glucose tolerance and enhances insulin secretion in Sprague-Dawley rats . AMG 837 (0.5 mg/kg; p.o.) displays excellent oral bioavailability (F = 84%) and a total plasma C max of 1.4 µM . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8-week old Zucker Fatty Rats Dosage: 0.03, 0.1, 0.3 mg/kg Administration: Oral gavage once daily for 21 days Result: Decreased glucose AUC values during the glucose tolerance test (GTT) to 7%, 15%, and 25% at 0.03, 0.1 and 0.3 mg/kg, respectively. Increased insulin levels in the mid- and high-dose groups. Not affected body weights during the 21-day treatment. Animal Model: 8-week old Sprague-Dawley rats Dosage: 0.03, 0.1, 0.3 mg/kg Administration: A single p.o. administration Result: Reduced the post-prandial glucose with the half-maximal dose of 0.05 mg/kg.
Form:Solid
IC50& Target:pIC50: 8.13 (FFA1)
规格
别名
AMG 837 氢氧化钙
规格或纯度
≥98%
英文名称
AMG 837 calcium hydrate
生化机理
AMG 837 水合钙是一种强效、口服生物利用度高的 GPR40/FFA1 部分激动剂。AMG 837 水合钙抑制人 FFA1 受体的特异性 [ 3 H]AMG 837 结合，pIC 50 为 8.13。AMG 837 水合钙可增强胰岛素分泌。
储存条件
2-8°C储存,干燥
运输条件
低温运输
作用类型
激动剂
纯度
≥98%
名称和识别符
分子类型
小分子
IUPAC Name
calcium;(3S)-3-[4-[[3-[4-(trifluoromethyl)phenyl]phenyl]methoxy]phenyl]hex-4-ynoate;hydrate
INCHI
1S/2C26H21F3O3.Ca.H2O/c2*1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29;;/h2*3,5-15,21H,16-17H2,1H3,(H,30,31);;1H2/q;;+2;/p-2/t2*21-;;/m00../s1
InChi Key
QDINKBCSIAWNMP-XYDYARRRSA-L
Smiles
CC#CC(CC(=O)[O-])C1=CC=C(C=C1)OCC2=CC(=CC=C2)C3=CC=C(C=C3)C(F)(F)F.CC#CC(CC(=O)[O-])C1=CC=C(C=C1)OCC2=CC(=CC=C2)C3=CC=C(C=C3)C(F)(F)F.O.[Ca+2]
PubChem CID
分子量
455.45
技术文档
高级数据
三维结构
交互式化学结构模型
化学和物理性质
溶解性
DMSO : ≥ 42 mg/mL (92.22 mM)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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