计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Ablukast (Ro 23-3544) is a specific and active leukotriene receptor antagonist. Ablukast effectively reduces LTC4- and antigen-induced bronchoconstriction. Ablukast is LTD4 receptor antagonist .
In Vitro
Ablukast (Ro 23-3544) is tested for its efficacy in modulating dinitrofluorobenzene (DNFB)-induced allergic and croton oil-induced irritant contact dermatitis in mouse ears. Treatment shortly after elicitation of the dermatitis, and for up to 5 days thereafter, was moderately effective in suppressing DNFB-induced ear swelling in a dose-dependent fashion. Daily pre-treatment of the ears for 1 week causes a more marked reduction of DNFB-induced ear swelling during the first 48 h after elicitation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ablukast (Ro 23-3544) is tested for its efficacy in modulating dinitrofluorobenzene (DNFB)-induced allergic and croton oil-induced irritant contact dermatitis in mouse ears. Treatment shortly after elicitation of the dermatitis, and for up to 5 days thereafter, was moderately effective in suppressing DNFB-induced ear swelling in a dose-dependent fashion. Daily pre-treatment of the ears for 1 week causes a more marked reduction of DNFB-induced ear swelling during the first 48 h after elicitation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female BALB/c miceDosage: Concentrations of 0.1 , 0.5 , 1.0 and 5.0 % of Ablukast Administration: Applied to one of the pretreated ears 1 h after elicitation and at 24 h intervals on the following 4 days; three times daily Result: Effectively reduced DNFB-induced ear swelling.
Form:Solid
规格
别名
阿布鲁司特
规格或纯度
≥99%
英文名称
Ablukast
生化机理
阿鲁司特（Ro 23-3544）是一种特异性和活性白三烯受体拮抗剂。阿鲁司特能有效减轻 LTC4 和抗原诱导的支气管收缩。Ablukast 是 LTD4 受体拮抗剂。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
拮抗剂
纯度
≥99%
名称和识别符
分子类型
小分子
Isomeric SMILES
CCCC1=C(C=CC(=C1O)C(=O)C)OCCCCCOC2=C(C=C3CCC(OC3=C2)C(=O)O)C(=O)C
PubChem CID
分子量
498.56
技术文档
高级数据
关联靶点（人）
CYSLTR1
Tclin
Cysteinyl leukotriene receptor 1
(2118 活性数据)
TBXAS1
Tchem
Thromboxane-A synthase
(3355 活性数据)
PDE1A
Tclin
Phosphodiesterase 1A
(251 活性数据)
LTB4R2
Tchem
Leukotriene B4 receptor
(773 活性数据)
关联靶点（其它种属）
Cavia porcellus (23802 活性数据)
Rattus norvegicus (775804 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
溶解性
DMSO : 100 mg/mL (200.58 mM; Need ultrasonic)
分子量
498.600 g/mol
XLogP3
5.500
氢键供体数Hydrogen Bond Donor Count
2
氢键受体数Hydrogen Bond Acceptor Count
8
可旋转键计数Rotatable Bond Count
13
精确质量Exact Mass
498.225 Da
单同位素质量Monoisotopic Mass
498.225 Da
拓扑极表面积Topological Polar Surface Area
119.000 Ų
重原子数Heavy Atom Count
36
形式电荷Formal Charge
0
复杂度Complexity
739.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
1
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）