计算溶液所需的质量、体积或浓度。
为什么选择此级别
提供 ≥98% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
干燥,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.
In Vitro
Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC 50 s in the range of 10 to 100 nM. ?\nAngstrom6 potentiates the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling, as evidenced by focal adhesion kinase and MAP/ERK kinase phosphorylation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl/6 mice (bearing B16-F10 cells)Dosage: 100 mg/kg Administration: S.c.; twice a day for 11 days Result: Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control.
Form:Solid
规格
规格或纯度
≥98%
英文名称
Angstrom6
生化机理
Angstrom6（A6 肽）是从单链尿激酶纤溶酶原激活剂（scuPA）中提取的 8 个氨基酸肽，可干扰 uPA/uPAR 级联反应并减弱下游效应。Angstrom6 可与 CD44 结合，从而抑制迁移
储存条件
干燥,-80℃储存
运输条件
特低温运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
分子类型
小分子
分子量
910.97
技术文档
高级数据
化学和物理性质
溶解性
H2O : ≥ 100 mg/mL (109.77 mM) DMSO : 100 mg/mL (109.77 mM; Need ultrasonic)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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