计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
为什么选择此级别
提供 ≥99% 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2 . β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase ( AChE ) activity. β-Amyrone can be used in the research of disease like inflammation, infection , and obesity
In Vitro
β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO ∙ production in LPS-stimulated J774 cells, with an IC 50 value of 4.61 μg/mL, and has no obvious effect on cell viability. β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells. β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC 50 value of 86 uM. β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC 50 values of 25 μM, 23 μM and 8 μg/mL, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: LPS (1 μg/mL)-stimulated J774 cells Concentration: 2.5, 5, 10 μg/mL Incubation Time: 24 h Result: Inhibited COX-2 expression in a concentration-dependent manner (approximately 90% reduction at 5 or 10 μg/ mL).
In Vivo
β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Ear phenol-induced edema in Balb C mice Dosage: 0.1, 0.3, 0.6 mg/kg, a single dose Administration: Local administration (20
规格
别名
β-阿米隆酮
英文别名
(6aR,6bS,8aR,12aS,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-2,4a,5,6,7,8,9,10,12,12a,14,14a-dodecahydro-1H-picen-3-one | AKOS032948475 | SCHEMBL2453965 | Olean-12-en-3-one | DTXSID20980370
规格或纯度
≥99%
英文名称
β-Amyrone
储存条件
避光,-80℃储存
运输条件
特低温运输
纯度
≥99%
名称和识别符
分子类型
小分子
IUPAC Name
(6aR,6bS,8aR,12aS,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-2,4a,5,6,7,8,9,10,12,12a,14,14a-dodecahydro-1H-picen-3-one
INCHI
1S/C30H48O/c1-25(2)15-16-27(5)17-18-29(7)20(21(27)19-25)9-10-23-28(6)13-12-24(31)26(3,4)22(28)11-14-30(23,29)8/h9,21-23H,10-19H2,1-8H3/t21-,22?,23-,27-,28+,29-,30-/m1/s1
InChi Key
LIIFBMGUDSHTOU-GCNWHLNUSA-N
Smiles
CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(=O)C5(C)C)C)C)C2C1)C)C)C
Isomeric SMILES
C[C@@]12CC[C@@]3(C(=CC[C@H]4[C@]3(CCC5[C@@]4(CCC(=O)C5(C)C)C)C)[C@H]1CC(CC2)(C)C)C
关联CAS
MeSH Entry Terms
olean-12-en-3-one;olean-18-en-3-one
分子量
424.70
Reaxy-Rn
25434450
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25434450&ln=
技术文档
高级数据
三维结构
交互式化学结构模型
关联靶点（人）
CES1
Tchem
肝羧酸酯酶1(Liver carboxylesterase 1)
(0 活性数据)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品的纯度是多少？
本产品的化学纯度（含量）为 ≥99%。批次的具体数值以分析证书（COA）为准。
本产品应如何储存？
请于?80 °C、避光条件下保存。本品对光敏感，请保存在原始的避光或棕色容器中。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 638-97-1，分子式为 C30H48O，分子量为 424.70 g/mol。InChIKey LIIFBMGUDSHTOU-GCNWHLNUSA-N。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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