The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

规格

别名

AKT 激酶抑制剂

规格或纯度

10mM in DMSO

英文名称

AKT Kinase Inhibitor

生化机理

AKT 激酶抑制剂是一种具有抗肿瘤活性的 Akt 激酶抑制剂。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

抑制剂

名称和识别符

分子类型

小分子

Isomeric SMILES

CCN1C2=C(C(=NC=C2OCCCN)C#CCO)N=C1C3=NON=C3N

关联CAS

842148-40-7

PubChem CID

25023726

分子量

357.37

高级数据

关联靶点（人）

ROCK1 Tclin Rho 相关蛋白激酶 1(Rho-associated protein kinase 1) (1 活性数据)

点击查看靶蛋白信息： ROCK1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

RPS6KA1 Tchem 核糖体蛋白 S6 激酶 α-1(Ribosomal protein S6 kinase alpha-1) (1 活性数据)

点击查看靶蛋白信息： RPS6KA1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

AKT1 Tchem RAC-alpha 丝氨酸/苏氨酸蛋白激酶(RAC-alpha serine/threonine-protein kinase) (1 活性数据)

点击查看靶蛋白信息： AKT1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

AKT通路的组成、激活机制与生物学效应

目录：技术文章

探索主题:

代谢调控 GSK3 AKT PKB PI3K PTEN PDK1 mTORC2 FOXO 细胞存活

Composition, Activation Mechanisms, and Biological Effects of the AKT Pathway

目录：技术文章

探索主题:

metabolic regulation GSK3 AKT PKB PI3K PTEN PDK1 mTORC2 FOXO cell survival

Angiopoietin-TIE2信号通路的血管稳态、通透性调控与病理性血管重塑机制

目录：技术文章

探索主题:

血管生成 Angiopoietin 内皮屏障 TIE2 TEK ANGPT1 ANGPT2 TIE1

Angiopoietin-TIE2 Signaling Pathway: Mechanisms of Vascular Homeostasis, Permeability Regulation, and Pathological Vascular Remodeling

目录：技术文章

探索主题:

VEGF Angiogenesis Angiopoietin endothelial barrier Vascular permeability inflammatory microenvironment TIE2 TEK ANGPT1 ANGPT2 TIE1 pericytes tumor vessels endothelial homeostasis

溶液计算器