(E)-Akt inhibitor-IV (compound 7) exhibits average GI 20 of 0.04 μM on four cell lines (MDA-MB468 cells, MDA-MB231 cells, MCF7 cells and 184B5 cells). (E)-Akt inhibitor-IV shows little effects on the growth of 184B5 non-cancer cells at the average GI 20 doses. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Akt

规格

别名

(E)-Akt 抑制剂-IV

规格或纯度

10mM in DMSO

英文名称

(E)-Akt inhibitor-IV

生化机理

(E)-Akt抑制剂-IV（(E)-AKTIV）是一种PI3K-Akt抑制剂，具有很强的细胞毒性。

储存条件

干燥,-80℃储存

运输条件

特低温运输

作用类型

抑制剂

名称和识别符

分子类型

小分子

PubChem CID

163285845

分子量

614.54

高级数据

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

AKT通路的组成、激活机制与生物学效应

目录：技术文章

探索主题:

代谢调控 GSK3 AKT PKB PI3K PTEN PDK1 mTORC2 FOXO 细胞存活

Composition, Activation Mechanisms, and Biological Effects of the AKT Pathway

目录：技术文章

探索主题:

metabolic regulation GSK3 AKT PKB PI3K PTEN PDK1 mTORC2 FOXO cell survival

Angiopoietin-TIE2信号通路的血管稳态、通透性调控与病理性血管重塑机制

目录：技术文章

探索主题:

血管生成 Angiopoietin 内皮屏障 TIE2 TEK ANGPT1 ANGPT2 TIE1

Angiopoietin-TIE2 Signaling Pathway: Mechanisms of Vascular Homeostasis, Permeability Regulation, and Pathological Vascular Remodeling

目录：技术文章

探索主题:

VEGF Angiogenesis Angiopoietin endothelial barrier Vascular permeability inflammatory microenvironment TIE2 TEK ANGPT1 ANGPT2 TIE1 pericytes tumor vessels endothelial homeostasis

溶液计算器