计算溶液所需的质量、体积或浓度。
概述
ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor ( AR ) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR -positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC 50 values of 0.2-1 n
Appearance:Solid
IC50& Target:VHL
In Vitro:ARD-266 (Compound 11; 100 nM; 1-24 hours; LNCaP and VCaP cells) treatment effectively reduces the AR protein level within 3 h and achieves near-complete AR elimination with a 6 h treatment in the LNCaP cells. ARD-266 (Compound 11; 1-10000 nM; 24 hour
Biological Activity:ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor ( AR ) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR -positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC 50 values of 0.2-1 n
规格
规格或纯度
≥99%
英文名称
ARD-266
储存条件
-20°C储存
运输条件
超低温运输
作用类型
抑制剂
纯度
≥99%
名称和识别符
分子类型
小分子
分子量
915.51
高级数据
化学和物理性质
溶解性
DMSO : 100 mg/mL (109.23 mM; Need ultrasonic)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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危险品化学品经营许可证（带存储）