计算溶液所需的质量、体积或浓度。
概述
Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib ( HY-16297A ), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader
Appearance:Solid
IC50& Target:CDK4 CDK6
In Vitro:Abemaciclib metabolite M18 hydrochloride exhibits T 1/2 of 43.1 hr in plasma in healthy subjects. CDK4/6 inhibitors’ chief mechanism of action is inhibition of retinoblastoma (RB) protein phosphorylation and thus the induction of cell cycle arrest, C
In Vivo:CDK4/6 inhibitors results T-cell persistence and immunologic memory increasing in mice receiving tumor-specific CD8 + T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Biological Activity:Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib ( HY-16297A ), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader
规格
别名
Abemaciclib 代谢物 M18 盐酸盐
规格或纯度
≥98%
英文名称
Abemaciclib metabolite M18 hydrochloride
储存条件
2-8°C储存,干燥
运输条件
低温运输
作用类型
抑制剂
纯度
≥98%
名称和识别符
分子类型
小分子
分子量
531
高级数据
化学和物理性质
溶解性
DMSO : 125 mg/mL (235.40 mM; Need ultrasonic) H2O : 100 mg/mL (188.32 mM; Need ultrasonic)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 SSE:688179 保留所有权利。
危险品化学品经营许可证（带存储）