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Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer.
Appearance:Solid
In Vitro:Paclitaxel is conjugated to a brain peptide vector, Angiopep-2, to provide a paclitaxel– Angiopep-2 conjugate named ANG1005. ANG1005 enters the brain to a greater extent than paclitaxel and bypasses the P-gp. ANG1005 has an antineoplastic potency similar
In Vivo:ANG1005 administration leads to a significant increase in the survival of mice with intracerebral implantation of U87 MG glioblastoma cells or NCI-H460 lung carcinoma cells. MCE has not independently confirmed the accuracy of these methods. They are
Biological Activity:Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer.