Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Post-translational: N-glycosylated. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
宿主种属
小鼠(Mouse)
特异性
THBD
种属反应性
人(Human)
免疫原
Recombinant thrombomodulin protein.
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
纯化方法
Antigen affinity chromatography
配对抗体
[Ab131028] Thrombomodulin Mouse mAb as Capture antibody in CLIA
危险品化学品经营许可证（带存储）