The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.
TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC).
The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13.
The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C.
TBP forms the TFIID-A module together with TAF3 and TAF5.
TBP is a general transcription factor that functions at the core of the TFIID complex.
During assembly of the core PIC on the promoter, as part of TFIID, TBP binds to and also bends promoter DNA, irrespective of whether the promoter contains a TATA box.
Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III.
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC during RNA polymerase I-dependent transcription.
The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promote.
SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
宿主种属
小鼠(Mouse)
特异性
Human TATA binding protein
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
Recombinant full length protein corresponding to human TATA binding protein
TATA binding protein Mouse mAb (Ab156573) - Western Blot All lanes: TATA binding protein Mouse mAb (Ab156573) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution
Predicted band size: 38 kDa Observed band size: 45 kDa Exposure time: 60.0 s
TATA binding protein Mouse mAb (Ab156573) - Western Blot All lanes: TATA binding protein Mouse mAb (Ab156573) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution
Predicted band size: 38 kDa Observed band size: 41 kDa Exposure time: 60.0 s
ZJ25F0927970
危险品化学品经营许可证（带存储）