Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis.
宿主种属
小鼠(Mouse)
特异性
Human Fas
种属反应性
人(Human)
免疫原
Recombinant protein corresponding to Human Fas
阳性对照
Flow Cytometry: Jurkat cells
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
1.0 mg/mL
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 7.2
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at 2-8℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
图片
Fas Mouse mAb (Ab169198) - Flow Cytometry Flow Cytometry analysis of Jurkat cells stained with Fas Mouse mAb (Ab169198) (Red) at 2.5 μg/mL for 1 hour at 4°C. The Goat Anti-Mouse IgG H&L (FITC) (Ab179003) was used as the secondary antibody. Unlabeled sample (Black) was used as a negative control. Mouse IgG1-kappa, anti-E8L (Ab213557) was used as an isotype control (Blue).
ZJ25F0623189
危险品化学品经营许可证（带存储）