Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.
O-glycosylated.
Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
宿主种属
小鼠(Mouse)
特异性
Canine CD8 alpha
免疫原
Recombinant protein corresponding to Canine CD8 alpha
Flow Cytometry analysis of beagle canine peripheral blood lymphocytes with Canine CD8 Mouse mAb (Ab170665) at 5 μg/mL for 1 hour at 4°C (right panel). Goat Anti-Mouse IgG H&L Antibody (AF488) was used as the secondary antibody. Mouse IgG (Ab170221) was used as an isotype control (left panel).
Canine CD8 Mouse mAb (Ab170665) - Flow Cytometry
Flow Cytometry analysis of beagle canine peripheral blood lymphocytes with Canine CD8 Mouse mAb (Ab170665) at 5 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG H&L Antibody (AF488) was used as the secondary antibody. Unlabeled sample was used as a negative control (Black). Mouse IgG (Ab170221) was used as an isotype control (Blue).
ZJ26F0433985
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