C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
Serum Albumin: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
宿主种属
人(Human)
种属反应性
人(Human)
偶联
Unconjugated
克隆类型
重组抗体
Format
VH-VH
纯化方法
Protein A purified
浓度
见COA
CAS编号和信息
2456407-94-4
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
10mM PBS, pH 7.4.
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
稳定性与储存
短期储存2-8℃(1-2周);长期储存-80℃(36个月);收货后建议分装,避免反复冻融。
图片
Gefurulimab (anti-C5&Albumin) (Ab182984) - SEC The purity of Gefurulimab (anti-C5&Albumin) (Ab182984) is more than 95% verified by HPLC.