ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥90%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Pinatuzumab vedotin (anti-CD22) 是一种抗体-药物缀合物 (ADC)，由 CD22（唾液酸结合 Ig 样凝集素 2、SIGLEC2、SIGLEC-2、B -淋巴细胞粘附分子、BL-CAM、Leu-14) 抗体和细胞毒性剂单甲基 auristatin E (MMAE) 通过马来酰亚胺己酰基-缬氨酰-瓜氨酸基-对氨基苄氧羰基 (mc-val-cit-PABC) 缀合 ) 类型链接器。
Pinatuzumab vedotin (anti-CD22), is an antibody-drug conjugate (ADC) composed of CD22 (Sialic acid binding Ig-like lectin 2, SIGLEC2, SIGLEC-2, B-lymphocyte cell adhesion molecule, BL-CAM, Leu-14) antibody and cytotoxic agent monomethyl auristatin E (MMAE) conjugated through maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker.
Purity
≥90% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg
Pinatuzumab vedotin (anti-CD22) (Ab183323) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD22 with Pinatuzumab vedotin (anti-CD22) (Ab183323) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
Pinatuzumab vedotin (anti-CD22) (Ab183323) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD22 (red) with Pinatuzumab vedotin (anti-CD22) (Ab183323) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
Pinatuzumab vedotin (anti-CD22) (Ab183323) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD22 (red) with Pinatuzumab vedotin (anti-CD22) (Ab183323). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Pinatuzumab vedotin (anti-CD22) (Ab183323) - ELISA
Immobilized Recombinant Human Siglec-2/CD22 protein (rp169575) at 1.0 μg/mL can bind Pinatuzumab vedotin (anti-CD22) (Ab183323) with the EC50 of 73.42 ng/mL.
Pinatuzumab vedotin (anti-CD22) (Ab183323) - SEC
The purity of Pinatuzumab vedotin (anti-CD22) (Ab183323) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0708977 |
分析证书 | Ab183323 |
| ZJ24F0708978 |
分析证书 | Ab183323 |
| ZJ24F0708979 |
分析证书 | Ab183323 |
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