Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity).
It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity).
May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity).
May play a role in mast cell development (By similarity).
Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038)
宿主种属
大鼠(Rat)
特异性
CD11b
种属反应性
人(Human),小鼠(Mouse)
免疫原
C57BL/10 splenocytes
阳性对照
Flow Cytometry: Human peripheral blood monocyte
偶联
AF647
Excitation(nm)
Red Laser(633nm)
Emission(nm)
668nm
Ex/Em(nm)
Ex:650nm;Em:668nm
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
0.5 mg/mL
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.
防腐剂
0.05% Proclin300
储存条件
2-8°C储存,避光,禁止冷冻
运输条件
低温运输,禁止冷冻
稳定性与储存
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
图片
Recombinant CD11b Antibody (AF647) (Ab213134) - Flow Cytometry Flow cytometry analysis of CD11b expression by human peripheral blood cells (right panel) compared to an isotype control (left panel). Cells were stained with Recombinant CD11b Antibody (AF647) (Ab213134) at 0.012μg/test for 1 hour at 4°C. Left panel - Mouse IgG (AF647) (Ab190077).
Recombinant CD11b Antibody (AF647) (Ab213134) - Flow Cytometry Flow cytometry analysis of CD11b expression by human peripheral blood monocytes (red) compared to an isotype control (blue). Cells were stained with Recombinant CD11b Antibody (AF647) (Ab213134) at 0.012μg/test for 1 hour at 4°C. Blue - Mouse IgG (AF647) (Ab190077). Black - Unlabelled control, cells without incubation with primary antibody.
应用
应用名称
稀释比例
Flow Cytometry
≤0.3μg/test
For flow cytometric staining, the suggested use of this reagent is ≤0.3 μg per million cells in 100 µL staining volume.
ZJ25F0218152
危险品化学品经营许可证（带存储）