Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity).
It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity).
May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity).
May play a role in mast cell development (By similarity).
Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038)..
宿主种属
大鼠(Rat)
特异性
CD11b
种属反应性
人(Human),小鼠(Mouse)
免疫原
C57BL/10 splenocytes
阳性对照
Flow Cytometry: Human peripheral blood monocyte
偶联
Unconjugated
备注
此产品可替代 Ab093718
克隆类型
重组抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 7.4
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
图片
Recombinant CD11b Antibody (Ab210604) - Flow Cytometry Flow Cytometry analysis of mouse bone marrow cells labelling CD11b with Recombinant CD11b Antibody (Ab210604) conjugated with biotin (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with Rat IgG Isotype Control Antibody (Biotin) (Ab180310) (left panel) and detected with SA-PE (rp156150).
Recombinant CD11b Antibody (Ab210604) - Flow Cytometry Flow Cytometry analysis of mouse bone marrow cells labelling CD11b (red) with Recombinant CD11b Antibody (Ab210604) conjugated with biotin at 0.2 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Rat IgG Isotype Control Antibody (Biotin) (Ab180310). Black - Unlabelled control, cells without incubation with primary antibody.
Recombinant CD11b Antibody (Ab210604) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD11b with Recombinant CD11b Antibody (Ab210604) conjugated with biotin (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with rat IgG (Ab180310) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
Recombinant CD11b Antibody (Ab210604) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD11b (red) with Recombinant CD11b Antibody (Ab210604) conjugated with biotin at 0.2 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Isotype control, rat IgG (Ab180310) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Recombinant CD11b Antibody (Ab210604) - SEC The purity of Recombinant CD11b Antibody (Ab210604) is more than 95% verified by HPLC.
ZJ25F0826218
危险品化学品经营许可证（带存储）