Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity).
Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity.
Recombinant CD45R Antibody (Ab219620) - Flow Cytometry Flow Cytometry analysis of C57BL/6 mouse splenocytes cells labelling CD45R with Recombinant CD45R Antibody (Ab219620) (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with Rat IgG Isotype Control Antibody (Ab141774) (left panel) and detected with AF 647 - conjugated affinipure goat anti - Rat IgG.
Recombinant CD45R Antibody (Ab219620) - Flow Cytometry Flow Cytometry analysis of C57BL/6 mouse splenocytes cells labelling CD45R (red) with Recombinant CD45R Antibody (Ab219620) at 0.2 μg/mL for 1 hour at 4°C and detected with AF 647 - conjugated affinipure goat anti - Rat IgG. Blue - Rat IgG Isotype Control Antibody (Ab141774). Black - Unlabelled control, cells without incubation with primary antibody.
Recombinant CD45R Antibody (Ab219620) - SEC The purity of Recombinant CD45R Antibody (Ab219620) is more than 95% verified by HPLC.
ZJ25F0927215
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